Zobrazeno 1 - 10
of 984
pro vyhledávání: '"W, Abbott"'
Autor:
Geoffrey W. Abbott, Rían W. Manville
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Plants remain an important source of biologically active small molecules with high therapeutic potential. The voltage-gated potassium (Kv) channel formed by Kv7.2/3 (KCNQ2/3) heteromers is a major target for anticonvulsant drug development.
Externí odkaz:
https://doaj.org/article/7bfd400cd29e43079ca60a5b65468044
Autor:
Rían W. Manville, Ryan F. Yoshimura, Andriy V. Yeromin, Derk Hogenkamp, Jennifer van der Horst, Angel Zavala, Sonia Chinedu, Grey Arena, Emma Lasky, Mark Fisher, Christopher R. Tracy, Shivashankar Othy, Thomas A. Jepps, Michael D. Cahalan, Geoffrey W. Abbott
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract Pain and inflammation contribute immeasurably to reduced quality of life, yet modern analgesic and anti-inflammatory therapeutics can cause dependence and side effects. Here, we screened 1444 plant extracts, prepared primarily from native sp
Externí odkaz:
https://doaj.org/article/5bae3235538b444ea2fc2392f2ec6cbc
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Human voltage-gated potassium (Kv) channels are expressed by a 40-member gene family that is essential for normal electrical activity and is closely linked to various excitability disorders. Function-altering sequence variants in the KCNB1 gene, whic
Externí odkaz:
https://doaj.org/article/0326e86d78be4eb4b3c853a9feeb8e44
Autor:
Rían W. Manville, Samantha D. Block, Claire L. Illeck, Jessica Kottmeier, Richard Sidlow, Geoffrey W. Abbott
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
KCNB1, on human chromosome 20q13.3, encodes the alpha subunit of the Kv2.1 voltage gated potassium channel. Kv2.1 is ubiquitously expressed throughout the brain and is critical in controlling neuronal excitability, including in the hippocampus and py
Externí odkaz:
https://doaj.org/article/d84a6ccc85894ddb8514efa947d07ff5
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract Voltage-gated potassium (Kv) channels in the KCNQ subfamily serve essential roles in the nervous system, heart, muscle and epithelia. Different heteromeric KCNQ complexes likely serve distinct functions in the brain but heteromer subtype-spe
Externí odkaz:
https://doaj.org/article/df90b352ce0044b6b23fe2eb931818f1
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract There are currently no drugs known to rescue the function of Kv1.1 voltage-gated potassium channels carrying loss-of-function sequence variants underlying the inherited movement disorder, Episodic Ataxia 1 (EA1). The Kwakwaka’wakw First Na
Externí odkaz:
https://doaj.org/article/82a898dd58e44dda95468975962d0bcb
Autor:
Guibiao Yang, Zhihu Zheng, Benjamin W. Abbott, David Olefeldt, Christian Knoblauch, Yutong Song, Luyao Kang, Shuqi Qin, Yunfeng Peng, Yuanhe Yang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Understanding methane (CH4) emission from thermokarst lakes is crucial for predicting the impacts of abrupt thaw on the permafrost carbon-climate feedback. However, observational evidence, especially from high-altitude permafrost regions, is
Externí odkaz:
https://doaj.org/article/f0d5208d96cf4cfe904021a1f5fc7e8f
Autor:
Benjamin W. Abbott, Chelsea Abrahamian, Nicholas Newbold, Peter Smith, Marina Merritt, Sayedeh Sara Sayedi, Jeremy Bekker, Mitchell Greenhalgh, Sophie Gilbert, Michalea King, Gabriel Lopez, Nils Zimmermann, Christian Breyer
Publikováno v:
Earth's Future, Vol 11, Iss 9, Pp n/a-n/a (2023)
Abstract The UN's Paris Agreement goal of keeping global warming between 1.5 and 2°C is dangerously obsolete and needs to be replaced by a commitment to restore Earth's climate. We now know that continued use of fossil fuels associated with 1.5–2
Externí odkaz:
https://doaj.org/article/e02fa76d2d1c49a8a7464a1ca04d1481
Autor:
Carson D. Thompson, Emilee Severe, Adam J. Norris, Jacob Gudmundsen, Mary Lewis, Elisabeth Currit, Nicholas Newbold, Benjamin W. Abbott
Publikováno v:
International Journal of Agricultural Sustainability, Vol 20, Iss 6, Pp 1079-1099 (2022)
Unsustainable agriculture practices are undermining the world's future ability to reliably produce food. Assistance programmes, such as those offered by the Natural Resource Conservation Service (NRCS) of the United States, can increase the uptake of
Externí odkaz:
https://doaj.org/article/2c83a44a8ea84f6389db2bf7338e88c6
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Renal ischemia/reperfusion (I/R) can induce acute kidney injury. Empagliflozin is a newly developed inhibitor of sodium-glucose cotransporter-2 (SGLT2) approved as an antidiabetic medication for patients with type 2 diabetes mellitus. Despit
Externí odkaz:
https://doaj.org/article/4fdf0bda58474b5f9f7b60099f24170a