Výsledky vyhledávání - "Vytautas Leoncikas"

Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics

Autor: Elaina M. Maldonado, Vytautas Leoncikas, Ciarán Fisher, Nick Plant, Andrzej M. Kierzek, J. Bernadette Moore

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology. 6:732-746

The scope of physiologically based pharmacokinetic (PBPK) modeling can be expanded by assimilation of the mechanistic models of intracellular processes from systems biology field. The genome scale metabolic networks (GSMNs) represent a whole set of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64183cd6f2477328384dc70cddf40e76
https://doi.org/10.1002/psp4.12230

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MUFINS: multi-formalism interaction network simulator

Publikováno v: Wu, H, von Kamp, A, Leoncikas, V, Mori, W, Sahin, N, Gevorgyan, A, Linley, C, Grabowski, M, Mannan, A A, Stoy, N, Stewart, G R, Ward, L T, Lewis, D J M, Sroka, J, Matsuno, H, Klamt, S, Westerhoff, H V, McFadden, J, Plant, N J & Kierzek, A M 2016, ' MUFINS: multi-formalism interaction network simulator ', npj Systems Biology and Applications, vol. 2, 16032 . https://doi.org/10.1038/npjsba.2016.32
Wu, H, von Kamp, A, Leoncikas, V, Mori, W, Sahin, N, Gevorgyan, A, Linley, C, Grabowski, M, Mannan, A A, Stoy, N, Stewart, G R, Ward, L T, Lewis, D J M, Sroka, J, Matsuno, H, Klamt, S, Westerhoff, H V, McFadden, J, Plant, N J & Kierzek, A M 2016, ' MUFINS: multi-formalism interaction network simulator ', NPJ systems biology and applications, vol. 2, 16032 . https://doi.org/10.10-38/npjsba.2016.32
Npj Systems Biology and Applications, 2:16032. Nature Publishing Group
NPJ systems biology and applications, 2:16032. Nature Publishing Group
NPJ Systems Biology and Applications
npj Systems Biology and Applications

Systems Biology has established numerous approaches for mechanistic modeling of molecular networks in the cell and a legacy of models. The current frontier is the integration of models expressed in different formalisms to address the multi-scale biol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd6bf56e90347353f6e06e9dd4b3e04
https://hdl.handle.net/11245.1/c7bb0d3f-c72b-4ff6-a05f-77ac5b025221

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Generation of 2,000 breast cancer metabolic landscapes reveals a poor prognosis group with active serotonin production

Autor: Vytautas Leoncikas, Huihai Wu, Nick Plant, Andrzej M. Kierzek, Lara Ward

Publikováno v: Scientific Reports

A major roadblock in the effective treatment of cancers is their heterogeneity, whereby multiple molecular landscapes are classified as a single disease. To explore the contribution of cellular metabolism to cancer heterogeneity, we analyse the Metab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90f090d674101cf59013d75a13caf15
http://europepmc.org/articles/PMC4728432

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Synergistic interaction between lipid-loading and doxorubicin exposure in Huh7 hepatoma cells results in enhanced cytotoxicity and cellular oxidative stress: implications for acute and chronic care of obese cancer patients

Autor: S. AlGhamdi, Vytautas Leoncikas, Nick Plant, Kathryn E. Plant

Publikováno v: Toxicology Research
Europe PubMed Central

Doxorubicin and lipid-loading (steatosis) interact synergistically in Huh7 hepatoma cells. This results in enhanced cytotoxicity and pro-inflammatory ROS accumulation.
There has been a dramatic increase in the number of clinically obese individu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23061526df99fd93f16bd08fde3f025e
https://pubmed.ncbi.nlm.nih.gov/26744621

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