Comparison of Microglial Morphology and Function in Primary Cerebellar Cell Cultures on Collagen and Collagen-Mimetic Hydrogels

Autor: Zbigniev Balion, Nataša Svirskienė, Gytis Svirskis, Hermanas Inokaitis, Vytautas Cėpla, Artūras Ulčinas, Tadas Jelinskas, Romuald Eimont, Neringa Paužienė, Ramūnas Valiokas, Aistė Jekabsone

Publikováno v: Biomedicines, Vol 10, Iss 5, p 1023 (2022)

Neuronal-glial cell cultures are usually grown attached to or encapsulated in an adhesive environment as evenly distributed networks lacking tissue-like cell density, organization and morphology. In such cultures, microglia have activated amoeboid mo

Externí odkaz: https://doaj.org/article/0157cf6b9d374638a7c0f525dcd5f66f

Introducing an Efficient In Vitro Cornea Mimetic Model for Testing Drug Permeability

Autor: Agnė Žiniauskaitė, Vytautas Cėpla, Tadas Jelinskas, Romuald Eimont, Artūras Ulčinas, Rūta Aldonytė, Ramūnas Valiokas, Giedrius Kalesnykas, Jenni J. Hakkarainen

Publikováno v: Sci, Vol 3, Iss 3, p 30 (2021)

There is a growing need for novel in vitro corneal models to replace animal-based ex vivo tests in drug permeability studies. In this study, we demonstrated a corneal mimetic that models the stromal and epithelial compartments of the human cornea. Hu

Externí odkaz: https://doaj.org/article/33de8134a50e463f9a89b36985e28610

Cerebellar Cells Self-Assemble into Functional Organoids on Synthetic, Chemically Crosslinked ECM-Mimicking Peptide Hydrogels

Autor: Zbigniev Balion, Vytautas Cėpla, Nataša Svirskiene, Gytis Svirskis, Kristina Druceikaitė, Hermanas Inokaitis, Justina Rusteikaitė, Ignas Masilionis, Gintarė Stankevičienė, Tadas Jelinskas, Artūras Ulčinas, Ayan Samanta, Ramūnas Valiokas, Aistė Jekabsone

Publikováno v: Biomolecules, Vol 10, Iss 5, p 754 (2020)

Hydrogel-supported neural cell cultures are more in vivo-relevant compared to monolayers formed on glass or plastic substrates. However, there is a lack of synthetic microenvironment available for obtaining standardized and easily reproducible cultur

Externí odkaz: https://doaj.org/article/a2b73af94b9342eaabbfec21e106937a

Cardiomyogenic Differentiation Potential of Human Dilated Myocardium-Derived Mesenchymal Stem/Stromal Cells: The Impact of HDAC Inhibitor SAHA and Biomimetic Matrices

Autor: Vytautas Cepla, Agne Vailionyte, Kestutis Rucinskas, Siegfried Labeit, Rokas Miksiunas, Ruta Aldonyte, Vilius Janusauskas, Daiva Bironaite, Gintare Stankeviciene, Ramunas Valiokas, Romuald Eimont, Tadas Jelinskas

Publikováno v: International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12702
International Journal of Molecular Sciences, Vol 22, Iss 12702, p 12702 (2021)
International journal of molecular sciences, Basel : MDPI, 2021, vol. 22, iss. 23, art. no.12702, p. 1-25
International Journal of Molecular Sciences

Dilated cardiomyopathy (DCM) is the most common type of nonischemic cardiomyopathy characterized by left ventricular or biventricular dilation and impaired contraction leading to heart failure and even patients’ death. Therefore, it is important to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93c3ff8f05b55a033847c67a88d85d9

ChemInform Abstract: Synthesis and Functionalization of 8-Methyl-2H-pyrimido[2,1-c][1,2,4]triazine-3,6(1H,4H)-dione

Autor: Povilas Vainilavicius, Milda M. Burbuliene, Virginija Jakubkiene, Vytautas Cepla

Publikováno v: ChemInform. 44

The title compound (II) is obtained by an intramolecular cyclization reaction of acetohydrazide (I).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d99ed1bf4c5b00205878b27c041b3fff
https://doi.org/10.1002/chin.201306129