Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca ²⁺ channel may modulate its β-adrenergic regulation.

Autor: Oz S; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel.; Department of Neuroscience, Faculty of Medicine, The Ruth and Bruce Rappaport, Haifa, 3109601, Israel., Keren-Raifman T; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel., Sharon T; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel., Subramaniam S; School of Neurobiology, Biochemistry and Biophysics, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997601, Israel., Pallien T; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Katz M; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel., Tsemakhovich V; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel., Sholokh A; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Watad B; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel., Tripathy DR; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel.; School of Neurobiology, Biochemistry and Biophysics, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997601, Israel.; National Forensic Science University, Radhanagar, Agartala, Tripura, 799001, India., Sasson G; School of Neurobiology, Biochemistry and Biophysics, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997601, Israel., Chomsky-Hecht O; School of Neurobiology, Biochemistry and Biophysics, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997601, Israel., Vysochek L; Heart Center, Sheba Medical Center, Ramat Gan, 5262000, Israel., Schulz-Christian M; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Fecher-Trost C; Experimentelle Und Klinische Pharmakologie & Toxikologie, Universität Des Saarlandes, Homburg, 66421, Germany., Zühlke K; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Bertinetti D; Department of Biochemistry, University of Kassel, Heinrich-Plett-Str. 40, Kassel, 34132, Germany., Herberg FW; Department of Biochemistry, University of Kassel, Heinrich-Plett-Str. 40, Kassel, 34132, Germany., Flockerzi V; Experimentelle Und Klinische Pharmakologie & Toxikologie, Universität Des Saarlandes, Homburg, 66421, Germany., Hirsch JA; School of Neurobiology, Biochemistry and Biophysics, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997601, Israel., Klussmann E; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany., Weiss S; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel. lahavsha@tauex.tau.ac.il., Dascal N; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel. dascaln@tauex.tau.ac.il.

Publikováno v: BMC biology [BMC Biol] 2024 Nov 28; Vol. 22 (1), pp. 276. Date of Electronic Publication: 2024 Nov 28.

Mutations in Na V 1.5 Reveal Calcium-Calmodulin Regulation of Sodium Channel.

Autor: Nof E; Heart Center, Sheba Medical Center, Ramat Gan, Israel.; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Vysochek L; Heart Center, Sheba Medical Center, Ramat Gan, Israel., Meisel E; Heart Center, Sheba Medical Center, Ramat Gan, Israel.; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Burashnikov E; Lankenau Institute for Medical Research, Wynnewood, PA, United States., Antzelevitch C; Lankenau Institute for Medical Research, Wynnewood, PA, United States.; Lankenau Heart Institute, Wynnewood, PA, United States.; Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States., Clatot J; Lankenau Institute for Medical Research, Wynnewood, PA, United States., Beinart R; Heart Center, Sheba Medical Center, Ramat Gan, Israel.; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Luria D; Heart Center, Sheba Medical Center, Ramat Gan, Israel., Glikson M; Heart Center, Sheba Medical Center, Ramat Gan, Israel.; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Oz S; Heart Center, Sheba Medical Center, Ramat Gan, Israel.

Publikováno v: Frontiers in physiology [Front Physiol] 2019 Jun 05; Vol. 10, pp. 700. Date of Electronic Publication: 2019 Jun 05 (Print Publication: 2019).

Extracellular Kir2.1 C122Y Mutant Upsets Kir2.1-PIP 2 Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome.

Autor: Cruz, Francisco M., Macías, Álvaro, Moreno-Manuel, Ana I., Gutiérrez, Lilian K., Vera-Pedrosa, María Linarejos, Martínez-Carrascoso, Isabel, Sánchez Pérez, Patricia, Ruiz Robles, Juan Manuel, Bermúdez-Jiménez, Francisco J., Díaz-Agustín, Aitor, Martínez de Benito, Fernando, Arias-Santiago, Salvador, Braza-Boils, Aitana, Martín-Martínez, Mercedes, Gutierrez-Rodríguez, Marta, Bernal, Juan A., Zorio, Esther, Jiménez-Jaimez, Juan, Jalife, José

Publikováno v: Circulation Research; 4/12/2024, Vol. 134 Issue 8, pe52-e71, 20p

Andersen–Tawil Syndrome Is Associated With Impaired PIP2 Regulation of the Potassium Channel Kir2.1.

Autor: Handklo-Jamal, Reem, Meisel, Eshcar, Yakubovich, Daniel, Vysochek, Leonid, Beinart, Roy, Glikson, Michael, McMullen, Julie R., Dascal, Nathan, Nof, Eyal, Oz, Shimrit

Publikováno v: Frontiers in Pharmacology; 5/15/2020, Vol. 11, p1-17, 17p

Interference with KCNJ2 inhibits proliferation, migration and EMT progression of apillary thyroid carcinoma cells by upregulating GNG2 expression.

Autor: Chen, Siyuan¹ (AUTHOR), Huang, Miaoming² (AUTHOR), Hu, Xiarong¹ (AUTHOR) huxiarong2020@163.com

Publikováno v: Molecular Medicine Reports. Sep2021, Vol. 24 Issue 3, pN.PAG-N.PAG. 1p.