Spatio-temporal biodistribution of 89Zr-oxine labeled huLym-1-A-BB3z-CAR T-cells by PET imaging in a preclinical tumor model

Autor: Naomi S. Sta Maria, Leslie A. Khawli, Vyshnavi Pachipulusu, Sharon W. Lin, Long Zheng, Daniel Cohrs, Xiaodan Liu, Peisheng Hu, Alan L. Epstein, Russell E. Jacobs

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Quantitative in vivo monitoring of cell biodistribution offers assessment of treatment efficacy in real-time and can provide guidance for further optimization of chimeric antigen receptor (CAR) modified cell therapy. We evaluated the utility

Externí odkaz: https://doaj.org/article/1a42eddcd18d4b17b25c6a34627d8118

Brain Disposition of Antibody-Based Therapeutics: Dogma, Approaches and Perspectives

Autor: Leslie A. Khawli, Alan L. Epstein, Aida Kouhi, Peisheng Hu, Talya Kapenstein, Vyshnavi Pachipulusu

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 6442, p 6442 (2021)

Due to their high specificity, monoclonal antibodies have been widely investigated for their application in drug delivery to the central nervous system (CNS) for the treatment of neurological diseases such as stroke, Alzheimer’s, and Parkinson’s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01dc7f6a931965d09341273747be8307
https://pubmed.ncbi.nlm.nih.gov/34208575