Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Vyacheslav V. Lyakhovich"'
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176939 (2017)
Tert-butylhydroquinone (tBHQ) is a highly effective phenolic antioxidant used in edible oils and fats in foods as well as in medicines and cosmetics. TBHQ has been shown to have both chemoprotective and carcinogenic effects. Furthermore, it has poten
Externí odkaz:
https://doaj.org/article/b47dc3852658494e8798bcaa4e2396a0
Autor:
Yulia A Sidorova, Maria L Perepechaeva, Elena N Pivovarova, Arkady L Markel, Vyacheslav V Lyakhovich, Alevtina Y Grishanova
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155135 (2016)
Oxidative reactions that are catalyzed by cytochromes P450 1A (CYP1A) lead to formation of carcinogenic derivatives of arylamines and polycyclic aromatic hydrocarbons (PAHs), such as the widespread environmental pollutant benzo(α)pyrene (BP). These
Externí odkaz:
https://doaj.org/article/e3a3300b3a9c4ca5a417f3964a50e7d6
Autor:
Vyacheslav V. Lyakhovich, Nikolay Varaksin, Alexsander Autenshlyus, Igor Marinkin, Kristina Davletova
Publikováno v:
International Journal of Immunopathology and Pharmacology
Introduction Breast cancer is a heterogeneous disease that has multiple molecular and morphological subtypes. Nonetheless, the relation between various molecular subtypes and functional characteristics of a tumor in terms of cytokine secretion remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9d172511dec655511e1d8fe7eece03
https://pubmed.ncbi.nlm.nih.gov/34399595
https://pubmed.ncbi.nlm.nih.gov/34399595
Autor:
A I Autenshlyus, V. A. Vavilin, Nikolay Varaksin, Vyacheslav V. Lyakhovich, Igor Marinkin, Elena Mikhailova, Sergey Arkhipov
Publikováno v:
International Journal of Immunopathology and Pharmacology
Currently, a number of promising strategies and approaches to cancer treatment include differentiation therapy. However, theoretical and methodological foundations of this field are not yet well developed. The objective of this study was to determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c67dd3086b2f0af824ea0066542436b
https://doi.org/10.1177/2058738420950580
https://doi.org/10.1177/2058738420950580
Autor:
Nikolai Slynko, Lyudmila F. Gulyaeva, Elena N. Pivovarova, Vladimir O. Pustylnyak, Vyacheslav V. Lyakhovich
Publikováno v:
Life Sciences. 85:815-821
Aim The aim of the current study was to investigate the species-specific induction of CYP2B by 2,4,6-tryphenyldioxane-1,3 (TPD) in relation to activation of CAR. Main methods 7-Pentoxyresorufin O-dealkylase (PROD) activity, RT-PCR, Western blot, Elec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d42c036e6ee94446fe3cadd292d28dd
https://doi.org/10.1016/j.lfs.2009.10.015
https://doi.org/10.1016/j.lfs.2009.10.015
Autor:
A. L. Markel, Elena N. Pivovarova, Yulia Sidorova, M. L. Perepechaeva, Alevtina Y. Grishanova, Vyacheslav V. Lyakhovich
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 5, p e0155135 (2016)
PLoS ONE, Vol 11, Iss 5, p e0155135 (2016)
Oxidative reactions that are catalyzed by cytochromes P450 1A (CYP1A) lead to formation of carcinogenic derivatives of arylamines and polycyclic aromatic hydrocarbons (PAHs), such as the widespread environmental pollutant benzo(a) pyrene (BP). These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378355f7f460875a9b96f201586a7172
https://pubmed.ncbi.nlm.nih.gov/27167070
https://pubmed.ncbi.nlm.nih.gov/27167070
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176939 (2017)
PLoS ONE
PLoS ONE
Tert-butylhydroquinone (tBHQ) is a highly effective phenolic antioxidant used in edible oils and fats in foods as well as in medicines and cosmetics. TBHQ has been shown to have both chemoprotective and carcinogenic effects. Furthermore, it has poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8284aa05f4a9235931806727ac1bb509
https://doi.org/10.1371/journal.pone.0176939
https://doi.org/10.1371/journal.pone.0176939
Publikováno v:
Biochemistry. Biokhimiia. 76(10)
Constitutive androstane receptor (CAR, NR1I3), which is under consideration in this review, is a member of the superfamily of nuclear receptors. However, certain features distinguish CAR from the variety of nuclear receptors. First, this receptor has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee08b83b055cad3e8684ef4cc87f1fb
https://pubmed.ncbi.nlm.nih.gov/22098234
https://pubmed.ncbi.nlm.nih.gov/22098234
Autor:
Ekaterina Kachaylo, Nikolai Slynko, Andrei A. Yarushkin, Vladimir O. Pustylnyak, Lyudmila F. Gulyaeva, Vyacheslav V. Lyakhovich
Publikováno v:
Chemico-biological interactions. 192(3)
2,4,6-Triphenyldioxane-1,3 (TPD) is a highly effective species-specific inducer of CYP2В in rats. Several analogs of TPD were synthesized to verify a hypothesis that minor changes in the inducer structure can cause changes in induction abilities (R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5be0ccc6f5c4e0cb1eca4544c319818
https://pubmed.ncbi.nlm.nih.gov/21453690
https://pubmed.ncbi.nlm.nih.gov/21453690
Autor:
Vyacheslav V. Lyakhovich, Lyudmila F. Gulyaeva, Anton N. Lebedev, Nikolaj M. Slynko, Vladimir O. Pustylnyak
Publikováno v:
Life sciences. 80(4)
Male Wistar rats and C57BL mice were treated by phenobarbital (PB), 2,4,6-triphenyldioxane-1,3 (TPD) and 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP). The CYP2B specific activities (PROD and BROD) were determined in the animal livers. PB admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69196120f9f70e55c8b4a2bdab271bb5
https://pubmed.ncbi.nlm.nih.gov/17045615
https://pubmed.ncbi.nlm.nih.gov/17045615