Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Vyacheslav Tretyachenko"'
Publikováno v:
PLoS Biology, Vol 22, Iss 3, p e3002570 (2024)
Some drugs increase the mutation rate of their target pathogen, a potentially concerning mechanism as the pathogen might evolve faster toward an undesired phenotype. We suggest a four-step assessment of evolutionary safety for the approval of such tr
Externí odkaz:
https://doaj.org/article/2890d1a322b94caeb3285185535317c4
Autor:
Vyacheslav Tretyachenko, Jiří Vymětal, Tereza Neuwirthová, Jiří Vondrášek, Kosuke Fujishima, Klára Hlouchová
Publikováno v:
Open Biology, Vol 12, Iss 6 (2022)
The earliest proteins had to rely on amino acids available on early Earth before the biosynthetic pathways for more complex amino acids evolved. In extant proteins, a significant fraction of the ‘late’ amino acids (such as Arg, Lys, His, Cys, Trp
Externí odkaz:
https://doaj.org/article/ebcdbbd8b3e748d3bbb6f2d971278c54
Autor:
Brennen Heames, Filip Buchel, Margaux Aubel, Vyacheslav Tretyachenko, Dmitry Loginov, Petr Novák, Andreas Lange, Erich Bornberg-Bauer, Klára Hlouchová
Publikováno v:
Nature Ecology & Evolution. 7:570-580
De novo gene emergence provides a route for new proteins to be formed from previously non-coding DNA. Proteins born in this way are considered random sequences and typically assumed to lack defined structure. While it remains unclear how likely a de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bcde73e6b486ef4bfd8bb0cfc820374
https://doi.org/10.1038/s41559-023-02010-2
https://doi.org/10.1038/s41559-023-02010-2
Autor:
Mikhail Makarov, Lucie Bednárová, Jingwei Meng, A. Keith Dunker, Jiří Vondrášek, Klára Hlouchová, Vyacheslav Tretyachenko, Valerio Guido Giacobelli, Anna Březinová, Pavel Srb
Publikováno v:
Protein Sci
The wide variety of protein structures and functions results from the diverse properties of the 20 canonical amino acids. The generally accepted hypothesis is that early protein evolution was associated with enrichment of a primordial alphabet, there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5703c95dd965f5d6745c8bb4bfd2e4ed
https://doi.org/10.1002/pro.4068
https://doi.org/10.1002/pro.4068
Autor:
null Vyacheslav Tretyachenko, null Jiří Vymětal, null Tereza Neuwirthová, null Jiří Vondrášek, null Kosuke Fujishima, null Klára Hlouchová
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f066519383a5cae8f0de42f966b61ea5
https://doi.org/10.1098/rsob.220040/v2/response1
https://doi.org/10.1098/rsob.220040/v2/response1
Autor:
Valerio G Giacobelli, Kosuke Fujishima, Martin Lepšík, Vyacheslav Tretyachenko, Tereza Kadavá, Mikhail Makarov, Lucie Bednárová, Petr Novák, Klára Hlouchová
Publikováno v:
Mol Biol Evol
RNA–peptide/protein interactions have been of utmost importance to life since its earliest forms, reaching even before the last universal common ancestor (LUCA). However, the ancient molecular mechanisms behind this key biological interaction remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc2a819df1ac193e57b6c9025d00514
https://pubmed.ncbi.nlm.nih.gov/35137196
https://pubmed.ncbi.nlm.nih.gov/35137196
Autor:
Vyacheslav Tretyachenko, Klára Hlouchová, Jiří Vymětal, Jiří Vondrášek, Kosuke Fujishima, Tereza Neuwirthová
Natural proteins represent numerous but tiny structure/function islands in a vast ocean of possible protein sequences not challenged by biological evolution and are yet to be explored by research. Recent studies have suggested this uncharted sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d92e313d321af8d927f33cdadba05ea3
https://doi.org/10.1101/2021.08.29.458031
https://doi.org/10.1101/2021.08.29.458031
Autor:
Lucie Bednárová, Klára Hlouchová, Martin Lepšík, Petr Novák, Tereza Kadavá, Valerio Guido Giacobelli, Kosuke Fujishima, Vyacheslav Tretyachenko
RNA-peptide/protein interactions have been of utmost importance to life since its earliest forms, reaching even before the last universal common ancestor (LUCA). However, the ancient molecular mechanisms behind this key biological interaction remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c2bccc5a034f7cf730f9787ec8653ce
https://doi.org/10.1101/2021.08.01.454623
https://doi.org/10.1101/2021.08.01.454623
Autor:
Jiří Vondrášek, Vyacheslav Tretyachenko, Lucie Bednárová, M. Makarov, A. K. Dunker, Klára Hlouchová, A. Brezinova, Jingwei Meng, Valerio Guido Giacobelli, Pavel Srb
It is well-known that the large diversity of protein functions and structures is derived from the broad spectrum of physicochemical properties of the 20 canonical amino acids. According to the generally accepted hypothesis, protein evolution was cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de184d86f436bd0a05c5b53d210af3a8
https://doi.org/10.1101/2020.11.11.377994
https://doi.org/10.1101/2020.11.11.377994
Autor:
Vyacheslav, Tretyachenko, Václav, Voráček, Radko, Souček, Kosuke, Fujishima, Klára, Hlouchová
Publikováno v:
Bioinformatics
Motivation Current techniques of protein engineering focus mostly on re-designing small targeted regions or defined structural scaffolds rather than constructing combinatorial libraries of versatile compositions and lengths. This is a missed opportun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d638bdeed82f84d58edd333e807669c1
https://pubmed.ncbi.nlm.nih.gov/32956450
https://pubmed.ncbi.nlm.nih.gov/32956450