Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Vyacheslav A. Sharapov"'
Autor:
Mikhail V. Dubinin, Irina B. Mikheeva, Anastasia E. Stepanova, Anastasia D. Igoshkina, Alena A. Cherepanova, Alena A. Semenova, Vyacheslav A. Sharapov, Igor I. Kireev, Konstantin N. Belosludtsev
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 316 (2024)
Duchenne muscular dystrophy is caused by loss of the dystrophin protein. This pathology is accompanied by mitochondrial dysfunction contributing to muscle fiber instability. It is known that mitochondria-targeted in vivo therapy mitigates pathology a
Externí odkaz:
https://doaj.org/article/5147bebf625f44df8404ef6370119d83
Autor:
Mikhail V. Dubinin, Darya A. Nedopekina, Anna I. Ilzorkina, Alena A. Semenova, Vyacheslav A. Sharapov, Eldar V. Davletshin, Natalia V. Mikina, Yuri P. Belsky, Anna Yu. Spivak, Vladimir S. Akatov, Natalia V. Belosludtseva, Jiankang Liu, Konstantin N. Belosludtsev
Publikováno v:
Membranes, Vol 13, Iss 6, p 563 (2023)
The present work shows the cytotoxic effects of novel conjugates of ursolic, oleanolic, maslinic, and corosolic acids with the penetrating cation F16 on cancer cells (lung adenocarcinoma A549 and H1299, breast cancer cell lines MCF-7 and BT474) and n
Externí odkaz:
https://doaj.org/article/e339fd2e58c7473da384490b7ffb9826
Autor:
Konstantin N. Belosludtsev, Anna I. Ilzorkina, Natalia V. Belosludtseva, Vyacheslav A. Sharapov, Nikita V. Penkov, Dmitriy A. Serov, Maxim N. Karagyaur, Darya A. Nedopekina, Eldar V. Davletshin, Marina E. Solovieva, Anna Yu Spivak, Ulyana Sh. Kuzmina, Yulia V. Vakhitova, Vladimir S. Akatov, Mikhail V. Dubinin
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2903 (2022)
The present study evaluates the cytotoxicity of a previously synthesized conjugate of betulinic acid (BA) with the penetrating cation F16 on breast adenocarcinoma (MCF-7) and human fibroblast (HF) cell lines, and also shows the mechanism underlying i
Externí odkaz:
https://doaj.org/article/d8db71920aa640569f976a059a164c58
Autor:
Mikhail V. Dubinin, Vyacheslav A. Sharapov, Alena A. Semenova, Lyudmila V. Parfenova, Anna I. Ilzorkina, Ekaterina I. Khoroshavina, Natalia V. Belosludtseva, Sergey V. Gudkov, Konstantin N. Belosludtsev
Publikováno v:
Membranes, Vol 12, Iss 9, p 866 (2022)
This paper demonstrates the membranotropic effect of modified levopimaric acid diene adducts on liver mitochondria and lecithin liposomes. We found that the derivatives dose-dependently reduced the efficiency of oxidative phosphorylation of mitochond
Externí odkaz:
https://doaj.org/article/dc620596d2484e668b44ca3d44c14494
Autor:
Mikhail V, Dubinin, Vyacheslav A, Sharapov, Anna I, Ilzorkina, Sergey V, Efimov, Vladimir V, Klochkov, Sergey V, Gudkov, Konstantin N, Belosludtsev
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1864:183972
The paper considers the effect of the MPT pore inhibitor cyclosporin A (CsA) and its non-immunosuppressive analogue alisporivir (Ali) on the functioning of rat skeletal muscle mitochondria. We have shown that both agents at a standard in vitro concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490b4388ad08811fd92fbd6fb3c68783
https://doi.org/10.1016/j.bbamem.2022.183972
https://doi.org/10.1016/j.bbamem.2022.183972
Autor:
Anna I. Ilzorkina, Mikhail V. Dubinin, Eldar V. Davletshin, Nikita V. Penkov, Vyacheslav A. Sharapov, Konstantin N. Belosludtsev, Natalia V. Belosludtseva, Anna Yu. Spivak, Alena A. Semenova, E. I. Khoroshavina, Darya A. Nedopekina
Publikováno v:
Free radical biologymedicine. 168
The paper examines the molecular mechanisms of the cytotoxicity of conjugates of betulinic acid with the penetrating cation F16. The in vitro experiments on rat thymocytes revealed that all the obtained F16-betulinic acid derivatives showed more than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cb98c4afe29c49d51f307f4e953869
https://pubmed.ncbi.nlm.nih.gov/33812008
https://pubmed.ncbi.nlm.nih.gov/33812008
Autor:
K. N. Belosludtsev, Mikhail V. Dubinin, Natalia V. Belosludtseva, Vyacheslav A. Sharapov, Kirill S. Tenkov, E. A. Kosareva
Publikováno v:
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 12:121-127
The effect of the lipophilic penetrating cation dequalinium on rat liver mitochondria was studied. It was found that dequalinium dose-dependently inhibits the respiration rate of rat liver mitochondria in ADP-stimulated (V3) and DNP-stimulated (uncou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88af066ccda02834c298e5b4362f4eb0
https://doi.org/10.1134/s1990747818020034
https://doi.org/10.1134/s1990747818020034
Autor:
I. B. Mikheeva, V. A. Vydrina, Nikita V. Penkov, Konstantin N. Belosludtsev, Anna I. Ilzorkina, Sergey V. Gudkov, Mikhail V. Dubinin, Vyacheslav A. Sharapov, E. I. Khoroshavina, Gumer Yu. Ishmuratov, Alena A. Semenova, V. A. Yashin
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1862:183383
The paper considers the effects of plant triterpenoid betulin and its derivative betulonic acid on rat liver mitochondria and liposomes. It was found that betulonic acid and, to a lesser extent, betulin, activate mitochondrial respiration in states 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65ba42cd7804d05a22e0c825c7e850e
https://doi.org/10.1016/j.bbamem.2020.183383
https://doi.org/10.1016/j.bbamem.2020.183383