A novel thermostable prokaryotic fucoidan active sulfatase PsFucS1 with an unusual quaternary hexameric structure

Autor: Maria Dalgaard Mikkelsen, Hang Thi Thuy Cao, Thomas Roret, Nanna Rhein-Knudsen, Jesper Holck, Van Thi Thanh Tran, Thuan Thi Nguyen, Vy Ha Nguyen Tran, Mateusz Jakub Lezyk, Jan Muschiol, Thinh Duc Pham, Mirjam Czjzek, Anne S. Meyer

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract Fucoidans are sulfated, fucose-rich marine polysaccharides primarily found in cell walls of brown seaweeds (macroalgae). Fucoidans are known to possess beneficial bioactivities depending on their structure and sulfation degree. Here, we repo

Externí odkaz: https://doaj.org/article/cc38177e7dd745e28e3da788539a2bda

The Endo-α(1,3)-Fucoidanase Mef2 Releases Uniquely Branched Oligosaccharides from Saccharina latissima Fucoidans

Autor: Vy Ha Nguyen Tran, Thuan Thi Nguyen, Sebastian Meier, Jesper Holck, Hang Thi Thuy Cao, Tran Thi Thanh Van, Anne S. Meyer, Maria Dalgaard Mikkelsen

Publikováno v: Marine Drugs, Vol 20, Iss 5, p 305 (2022)

Fucoidans are complex bioactive sulfated fucosyl-polysaccharides primarily found in brown macroalgae. Endo-fucoidanases catalyze the specific hydrolysis of α-L-fucosyl linkages in fucoidans and can be utilized to tailor-make fucoidan oligosaccharide

Externí odkaz: https://doaj.org/article/6581ee3d8f294f8db85b8b0891358a2f

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Depolymerization of fucoidan with endo-fucoidanase changes bioactivity in processes relevant for bone regeneration

Autor: Julia Ohmes, Maria Dalgaard Mikkelsen, Thuan Thi Nguyen, Vy Ha Nguyen Tran, Sebastian Meier, Mads Suhr Nielsen, Ming Ding, Andreas Seekamp, Anne S. Meyer, Sabine Fuchs

Publikováno v: Ohmes, J, Mikkelsen, M D, Thi, T N, Ha, V T N, Meier, S, Nielsen, M S, Ding, M, Seekamp, A, Meyer, A S & Fuchs, S 2022, ' Depolymerization of Fucoidan with Endo-Fucoidanase Changes Bioactivity in Processes Relevant for Bone Regeneration ', Carbohydrate Polymers, vol. 286, 119286 . https://doi.org/10.1016/j.carbpol.2022.119286
Ohmes, J, Mikkelsen, MD, Nguyen, TT, Tran, VHN, Meier, S, Nielsen, MS, Ding, M, Seekamp, A, Meyer, AS & Fuchs, S 2022, ' Depolymerization of fucoidan with endo-fucoidanase changes bioactivity in processes relevant for bone regeneration ', Carbohydrate Polymers, vol. 286, 119286 . https://doi.org/10.1016/j.carbpol.2022.119286

Fucoidans are polysaccharides from brown macroalgae, showing multiple bioactivities important for bone regeneration and bone health. However, the use of fucoidans in medical applications remains sparse due to the heterogeneity in their chemical prope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043e571bbffa1714e73956d73d08cc94
https://pubmed.ncbi.nlm.nih.gov/35337530

A novel thermostable prokaryotic fucoidan active sulfatase PsFucS1 with an unusual quaternary hexameric structure

Autor: Mirjam Czjzek, Anne S. Meyer, Van Thi Thanh Tran, Thuan Thi Nguyen, Thomas Roret, Nanna Rhein-Knudsen, Vy Ha Nguyen Tran, Jesper Holck, Thinh Duc Pham, Jan Muschiol, Hang Thi Thuy Cao, Maria Dalgaard Mikkelsen, Mateusz Jakub Lezyk

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), ⟨10.1038/s41598-021-98588-3⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Mikkelsen, M D, Cao, H T T, Roret, T, Rhein-Knudsen, N, Holck, J, Tran, V T T, Nguyen, T T, Tran, V H N, Lezyk, M J, Muschiol, J, Pham, T D, Czjzek, M & Meyer, A S 2021, ' A novel thermostable prokaryotic fucoidan active sulfatase PsFucS1 with an unusual quaternary hexameric structure ', Scientific Reports, vol. 11, 19523 . https://doi.org/10.1038/s41598-021-98588-3

Fucoidans are sulfated, fucose-rich marine polysaccharides primarily found in cell walls of brown seaweeds (macroalgae). Fucoidans are known to possess beneficial bioactivities depending on their structure and sulfation degree. Here, we report the fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62dc11e1d81c498f2731c0d306def462
https://doi.org/10.1038/s41598-021-98588-3