Over-expression of FOXM1 transcription factor is associated with cervical cancer progression and pathogenesis

Autor: Hextan Y.S. Ngan, Kwok-Ming Yao, S. Y. M. Yu, David W. Chan, Annie N.Y. Cheung, PM Chiu, Vws Liu

Publikováno v: The Journal of Pathology. 215:245-252

The Forkhead Box M1 (FOXM1) transcription factor plays a crucial role in regulating expression of cell cycle genes which are essentially involved in cell proliferation, differentiation and transformation. Recent studies have reported that aberrant ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa78bb3148d944f56017c3d82c8c84fe
https://doi.org/10.1002/path.2355

Association of decreased mitochondrial DNA content with ovarian cancer progression

Autor: Hextan Ys Ngan, Vws Liu, Wei-Cheng Xue, Annie N.Y. Cheung, Yifei Wang

Publikováno v: British Journal of Cancer

Mitochondrial DNA (mtDNA) content in ovarian carcinomas was assessed by quantitative PCR. Results show that mtDNA content in tumour cell was significantly higher than that in normal ovary. Change in mtDNA content was not related with patients' age or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227077e93a7fbcec133c94526b9bc5c1
https://doi.org/10.1038/sj.bjc.6603377

Detection of hypermethylated genes in tumor and plasma of cervical cancer patients

Autor: Hextan Ys Ngan, Y Wang, Annie N.Y. Cheung, Kelvin Y.K. Chan, Hui-Juan Yang, Percy C.K. Tsang, Ui-Soon Khoo, Vws Liu

Publikováno v: Gynecologic Oncology. 93:435-440

Objective . The aim of this study is to investigate the prevalence of promotor CpG island methylation of the death-associated protein kinase ( DAPK ), p16 , and O 6 -methylguanine-DNA methyltransferase ( MGMT ) genes in both tumor and plasma samples

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f5818acc69b48df7853ef0d4db74f4
https://doi.org/10.1016/j.ygyno.2004.01.039

Overexpression of FOXG1 contributes to TGF-β resistance through inhibition of p21 WAF1/CIP1 expression in ovarian cancer

Autor: W Y W Lee, Annie N.Y. Cheung, R M Y To, Kwok-Ming Yao, David W. Chan, PM Chiu, Vws Liu, Hextan Ys Ngan

Publikováno v: British Journal of Cancer

Background:Loss of growth inhibitory response to transforming growth factor-Β (TGF-Β) is a common feature of epithelial cancers. Recent studies have reported that genetic lesions and overexpression of oncoproteins in TGF-Β/Smads signalling cascade

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cfff383237abbc4a97db5f45b25bce
http://hdl.handle.net/10722/68131

Melatonin Inhibits Androgen Receptor Splice Variant-7 (AR-V7)-Induced Nuclear Factor-Kappa B (NF-κB) Activation and NF-κB Activator-Induced AR-V7 Expression in Prostate Cancer Cells: Potential Implications for the Use of Melatonin in Castration-Resistant Prostate Cancer (CRPC) Therapy.

Autor: Liu VWS; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China. vwsliu@hku.hk., Yau WL; Division of Nursing and Health Studies, School of Science and Technology, Open University of Hong Kong, Hong Kong, China. syau@ouhk.edu.hk., Tam CW; Division of Nursing and Health Studies, School of Science and Technology, Open University of Hong Kong, Hong Kong, China. cwtam@ouhk.edu.hk., Yao KM; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China. kmyao@hku.hk., Shiu SYW; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China. sywshiu@hku.hk.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2017 May 31; Vol. 18 (6). Date of Electronic Publication: 2017 May 31.