Automated Urinary Chemokine Assays for Noninvasive Detection of Kidney Transplant Rejection: A Prospective Cohort Study.

Autor: Van Loon E; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium., Tinel C; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven., de Loor H; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven., Bossuyt X; Clinical and Diagnostic Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven; Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium., Callemeyn J; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium., Coemans M; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven., De Vusser K; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium., Sauvaget V; INSERM U1151, Université de Paris, Paris, France., Olivre J; INSERM U1151, Université de Paris, Paris, France., Koshy P; Department of Imaging and Pathology, KU Leuven, Leuven., Kuypers D; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium., Sprangers B; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven; Laboratory of Molecular Immunology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven., Van Craenenbroeck AH; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium., Vaulet T; ESAT STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven., Anglicheau D; INSERM U1151, Université de Paris, Paris, France; Department of Nephrology and Kidney Transplantation, RTRS Centaure, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France., Naesens M; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium. Electronic address: maarten.naesens@uzleuven.be.

Publikováno v: American journal of kidney diseases : the official journal of the National Kidney Foundation [Am J Kidney Dis] 2024 Apr; Vol. 83 (4), pp. 467-476. Date of Electronic Publication: 2023 Sep 29.

An observational cohort study of histological screening for BK polyomavirus nephropathy following viral replication in plasma.

Autor: Cleenders E; Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium; Department of Public Health and Primary Care, Leuven Biostatistics and Statistical Bioinformatics Centre, KU Leuven, Leuven, Belgium., Koshy P; Department of Imaging and Pathology, University Hospitals Leuven, Leuven, Belgium., Van Loon E; Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium., Lagrou K; Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical Microbiology, KU Leuven, Leuven, Belgium., Beuselinck K; Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical Microbiology, KU Leuven, Leuven, Belgium; Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium., Andrei G; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, KU Leuven, Leuven, Belgium., Crespo M; Department of Nephrology, Hospital del Mar Medical Research Institute (IMIM), Hospital del Mar, Barcelona, Spain., De Vusser K; Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium., Kuypers D; Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium., Lerut E; Department of Imaging and Pathology, University Hospitals Leuven, Leuven, Belgium., Mertens K; Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium., Mineeva-Sangwo O; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, KU Leuven, Leuven, Belgium., Randhawa P; Division of Transplantation Pathology, the Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center-Montefiore Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Senev A; Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium; Histocompatibility and Immunogenetics Laboratory, Belgian Red Cross-Flanders, Mechelen, Belgium., Snoeck R; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, KU Leuven, Leuven, Belgium., Sprangers B; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Molecular Immunology, KU Leuven, Leuven, Belgium., Tinel C; Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium., Van Craenenbroeck A; Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium., van den Brand J; Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium., Van Ranst M; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Clinical and Epidemiological Virology, KU Leuven, Leuven, Belgium., Verbeke G; Department of Public Health and Primary Care, Leuven Biostatistics and Statistical Bioinformatics Centre, KU Leuven, Leuven, Belgium., Coemans M; Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium; Department of Public Health and Primary Care, Leuven Biostatistics and Statistical Bioinformatics Centre, KU Leuven, Leuven, Belgium., Naesens M; Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium. Electronic address: maarten.naesens@kuleuven.be.

Publikováno v: Kidney international [Kidney Int] 2023 Nov; Vol. 104 (5), pp. 1018-1034. Date of Electronic Publication: 2023 Aug 19.

Data-Driven Chronic Allograft Phenotypes: A Novel and Validated Complement for Histologic Assessment of Kidney Transplant Biopsies.

Autor: Vaulet T; ESAT Stadius Center for Dynamical Systems, Signal Processing, and Data Analytics, KU Leuven, Leuven, Belgium., Divard G; Paris Translational Research Center for Organ Transplantation, Université de Paris, INSERM, PARCC, Paris, France; Kidney Transplant Department, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France., Thaunat O; CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, Lyon, France.; Department of Transplantation, Nephrology, and Clinical Immunology, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France., Koshy P; Department of Imaging and Pathology, University Hospitals Leuven, Leuven, Belgium., Lerut E; Department of Imaging and Pathology, University Hospitals Leuven, Leuven, Belgium., Senev A; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.; Histocompatibility and Immunogenetics Laboratory, Belgian Red Cross-Flanders, Mechelen, Belgium., Aubert O; Paris Translational Research Center for Organ Transplantation, Université de Paris, INSERM, PARCC, Paris, France; Kidney Transplant Department, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France., Van Loon E; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium., Callemeyn J; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium., Emonds MP; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.; Histocompatibility and Immunogenetics Laboratory, Belgian Red Cross-Flanders, Mechelen, Belgium., Van Craenenbroeck A; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium., De Vusser K; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium., Sprangers B; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium., Rabeyrin M; Department of Pathology, Hospices Civils de Lyon, Bron, France., Dubois V; Human Leukocyte Antigen (HLA) Laboratory, French National Blood Service (EFS), Décines-Charpieu, France., Kuypers D; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium., De Vos M; ESAT Stadius Center for Dynamical Systems, Signal Processing, and Data Analytics, KU Leuven, Leuven, Belgium.; Department of Development and Regeneration, University Hospitals Leuven, KU Leuven, Leuven, Belgium., Loupy A; Paris Translational Research Center for Organ Transplantation, Université de Paris, INSERM, PARCC, Paris, France; Kidney Transplant Department, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France., De Moor B; ESAT Stadius Center for Dynamical Systems, Signal Processing, and Data Analytics, KU Leuven, Leuven, Belgium., Naesens M; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium.

Publikováno v: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2022 Nov; Vol. 33 (11), pp. 2026-2039. Date of Electronic Publication: 2022 Sep 07.

Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection.

Autor: Lamarthée B; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven, Belgium.; Université de Franche-Comté, UBFC, EFS, Inserm UMR RIGHT, Besançon, France., Callemeyn J; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven, Belgium.; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium., Van Herck Y; Department of Oncology, Laboratory for Experimental Oncology, KU Leuven, Leuven, Belgium., Antoranz A; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven, Leuven, Belgium., Anglicheau D; Department of Nephrology and Kidney Transplantation, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.; Université Paris Cité, Inserm U1151, Necker Enfants-Malades Institute, Paris, France., Boada P; Division of Multi-Organ Transplantation, Department of Surgery, UCSF, 513 Parnassus, San Francisco, CA, USA., Becker JU; Institute of Pathology, University Hospital Cologne, Cologne, Germany., Debyser T; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven, Belgium., De Smet F; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven, Leuven, Belgium., De Vusser K; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven, Belgium.; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium., Eloudzeri M; Université Paris Cité, Inserm U1151, Necker Enfants-Malades Institute, Paris, France., Franken A; VIB Center for Cancer Biology, Leuven, Belgium.; Department of Human Genetics, Laboratory of Translational Genetics, KU Leuven, Leuven, Belgium., Gwinner W; Department of Nephrology, Hannover Medical School, Hannover, Germany., Koshy P; Department of Imaging and Pathology, KU Leuven, Leuven, Belgium., Kuypers D; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven, Belgium.; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium., Lambrechts D; VIB Center for Cancer Biology, Leuven, Belgium.; Department of Human Genetics, Laboratory of Translational Genetics, KU Leuven, Leuven, Belgium., Marquet P; Department of Pharmacology and Transplantation, University of Limoges, Inserm U1248, Limoges University Hospital, Limoges, France., Mathias V; EFS, HLA Laboratory, Décines, France.; Université Claude Bernard Lyon I, Inserm U1111, CNRS UMR5308, CIRI, Ecole Normale Supérieure de Lyon, Lyon, France., Rabant M; Université Paris Cité, Inserm U1151, Necker Enfants-Malades Institute, Paris, France.; Department of Pathology, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France., Sarwal MM; Division of Multi-Organ Transplantation, Department of Surgery, UCSF, 513 Parnassus, San Francisco, CA, USA., Senev A; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven, Belgium.; Histocompatibility and Immunogenetics Laboratory, Red Cross-Flanders, Mechelen, Belgium., Sigdel TK; Division of Multi-Organ Transplantation, Department of Surgery, UCSF, 513 Parnassus, San Francisco, CA, USA., Sprangers B; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven, Belgium.; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium., Thaunat O; Université Claude Bernard Lyon I, Inserm U1111, CNRS UMR5308, CIRI, Ecole Normale Supérieure de Lyon, Lyon, France.; Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Transplantation, Nephrology and Clinical Immunology, Lyon, France., Tinel C; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven, Belgium.; Université de Franche-Comté, UBFC, EFS, Inserm UMR RIGHT, Besançon, France.; Department of Nephrology and Kidney Transplantation, Dijon Hospital, Dijon, France., Van Brussel T; VIB Center for Cancer Biology, Leuven, Belgium.; Department of Human Genetics, Laboratory of Translational Genetics, KU Leuven, Leuven, Belgium., Van Craenenbroeck A; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven, Belgium.; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium., Van Loon E; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven, Belgium.; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium., Vaulet T; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven, Belgium., Bosisio F; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven, Leuven, Belgium., Naesens M; Department of Microbiology, Immunology and Transplantation, Nephrology and Kidney Transplantation Research Group, KU Leuven, Leuven, Belgium. maarten.naesens@uzleuven.be.; Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium. maarten.naesens@uzleuven.be.

Publikováno v: Nature communications [Nat Commun] 2023 Jul 19; Vol. 14 (1), pp. 4359. Date of Electronic Publication: 2023 Jul 19.

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