Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Vuk Stambolic"'
Autor:
Lauren Podmore, Yekaterina Poloz, Catherine Iorio, Samar Mouaaz, Kevin Nixon, Petr Smirnov, Brianna McDonnell, Sonya Lam, Bowen Zhang, Pirashaanthy Tharmapalan, Soumili Sarkar, Foram Vyas, Marguerite Ennis, Ryan Dowling, Vuk Stambolic
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113251- (2023)
Summary: Breast cancer (BC) prognosis and outcome are adversely affected by obesity. Hyperinsulinemia, common in the obese state, is associated with higher risk of death and recurrence in BC. Up to 80% of BCs overexpress the insulin receptor (INSR),
Externí odkaz:
https://doaj.org/article/0a98286f0bdb4289aa404e39db449838
Autor:
Kamdin Mirsanaye, Leonardo Uribe Castaño, Yasmeen Kamaliddin, Ahmad Golaraei, Renaldas Augulis, Lukas Kontenis, Susan J. Done, Edvardas Žurauskas, Vuk Stambolic, Brian C. Wilson, Virginijus Barzda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract The extracellular matrix (ECM) collagen undergoes major remodeling during tumorigenesis. However, alterations to the ECM are not widely considered in cancer diagnostics, due to mostly uniform appearance of collagen fibers in white light imag
Externí odkaz:
https://doaj.org/article/44f65ce7065643f782a2d39581411984
Autor:
Pamela J. Goodwin, Ryan J. O. Dowling, Marguerite Ennis, Bingshu E. Chen, Wendy R. Parulekar, Lois E. Shepherd, Margot J. Burnell, Rachel Vander Meer, Andrea Molckovsky, Anagha Gurjal, Karen A. Gelmon, Jennifer A. Ligibel, Dawn L. Hershman, Ingrid A. Mayer, Timothy J. Whelan, Timothy J. Hobday, Priya Rastogi, Manuela Rabaglio-Poretti, Julie Lemieux, Alastair M. Thompson, Daniel W. Rea, Vuk Stambolic
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-8 (2021)
Abstract Metformin may exert anticancer effects through indirect (mediated by metabolic changes) or direct mechanisms. The goal was to examine metformin impact on metabolic factors in non-diabetic subjects and determine whether this impact varies by
Externí odkaz:
https://doaj.org/article/ed8c22cdd63b4d8ab3a69bbf18ba9909
Autor:
Ying-Ju Chang, Lily Zhou, Richard Binari, Armen Manoukian, Tak Mak, Helen McNeill, Vuk Stambolic
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0252252 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0152259.].
Externí odkaz:
https://doaj.org/article/5815747e49c44f1a80a568ff94fea182
Autor:
Ariana Rostami, Meghan Lambie, Caberry W. Yu, Vuk Stambolic, John N. Waldron, Scott V. Bratman
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107830- (2020)
Summary: The kinetics of circulating cell-free DNA (cfDNA) release may provide a real-time assessment of induced cell death. However, there is a limited understanding of the underlying biological rationale for cfDNA release following distinct treatme
Externí odkaz:
https://doaj.org/article/df1d58749d0d4dd696896af974a068ae
Autor:
Bert van de Kooij, Pau Creixell, Anne van Vlimmeren, Brian A Joughin, Chad J Miller, Nasir Haider, Craig D Simpson, Rune Linding, Vuk Stambolic, Benjamin E Turk, Michael B Yaffe
Publikováno v:
eLife, Vol 8 (2019)
Human NimA-related kinases (Neks) have multiple mitotic and non-mitotic functions, but few substrates are known. We systematically determined the phosphorylation-site motifs for the entire Nek kinase family, except for Nek11. While all Nek kinases st
Externí odkaz:
https://doaj.org/article/2383e1c7cf71416b992c19851aaee933
Autor:
Valentina Gandin, Laia Masvidal, Marie Cargnello, Laszlo Gyenis, Shannon McLaughlan, Yutian Cai, Clara Tenkerian, Masahiro Morita, Preetika Balanathan, Olivier Jean-Jean, Vuk Stambolic, Matthias Trost, Luc Furic, Louise Larose, Antonis E. Koromilas, Katsura Asano, David Litchfield, Ola Larsson, Ivan Topisirovic
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Ternary complex (TC) and eIF4F complex assembly are rate-limiting steps in translation initiation that are regulated by eIF2α phosphorylation and the mTOR/4E-BP pathway. Here the authors show that the protein kinases mTORC1 and CK2 coordinate TC and
Externí odkaz:
https://doaj.org/article/3b23e374915e42abafd814b872f5dd1d
Autor:
Ying-Ju Chang, Lily Zhou, Richard Binari, Armen Manoukian, Tak Mak, Helen McNeill, Vuk Stambolic
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152259 (2016)
The insulin/IGF-1 signaling pathway mediates various physiological processes associated with human health. Components of this pathway are highly conserved throughout eukaryotic evolution. In Drosophila, the PTEN ortholog and its mammalian counterpart
Externí odkaz:
https://doaj.org/article/e92396b3a24f482aa660954c8987946b
Autor:
Ying-Ju Chang, Scott Pownall, Thomas E Jensen, Samar Mouaaz, Warren Foltz, Lily Zhou, Nicole Liadis, Minna Woo, Zhenyue Hao, Previn Dutt, Philip J Bilan, Amira Klip, Tak Mak, Vuk Stambolic
Publikováno v:
eLife, Vol 4 (2015)
Adipose tissue is crucial for the maintenance of energy and metabolic homeostasis and its deregulation can lead to obesity and type II diabetes (T2D). Using gene disruption in the mouse, we discovered a function for a RhoA-specific guanine nucleotide
Externí odkaz:
https://doaj.org/article/88d9c968a27b4031b4373750c5e2dd80
Nek kinases are involved in regulating several different elements of the centrosomal cycle, primary cilia function, and DNA damage responses. Unlike the other members of the Nek family, which are serine-threonine kinases, Nek10 preferentially targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93b1f8227ed8ab1703725417e9b7cf6b
https://doi.org/10.1101/2022.12.23.521717
https://doi.org/10.1101/2022.12.23.521717