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Predicting drug efficacy in chronic low back pain by quantitative sensory tests

Autor: Schliessbach, J, Siegenthaler, A, Bütikofer, Lukas, Vuilleumier, Pascal Henri, Jüni, P, Stamer, Ulrike, Arendt-Nielsen, L, Curatolo, M

BACKGROUND Drugs are prescribed for chronic low back pain without knowing in advance whether a patient will respond to them or not. Quantitative sensory tests (QST) can discriminate patients according to sensory phenotype, possibly reflecting underly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db12f4f05d610a877b7846000410125e

Mutations affecting glycinergic neurotransmission in hyperekplexia increase pain sensitivity

Autor: Michele Curatolo, Hanns Ulrich Zeilhofer, Jürg Schliessbach, Raphael Fritsche, Lars Arendt-Nielsen, Pascal Henri Vuilleumier, Bernhard Schmitt

Publikováno v: Vuilleumier, Pascal Henri; Fritsche, Raphael; Schliessbach, Jürg; Schmitt, Bernhard; Arendt-Nielsen, Lars; Zeilhofer, Hanns Ulrich; Curatolo, Michele (2018). Mutations affecting glycinergic neurotransmission in hyperekplexia increase pain sensitivity. Brain, 141(1), pp. 63-71. Oxford University Press 10.1093/brain/awx289
Vuilleumier, P H, Fritsche, R, Schliessbach, J, Schmitt, B, Arendt-Nielsen, L, Zeilhofer, H U & Curatolo, M 2018, ' Mutations affecting glycinergic neurotransmission in hyperekplexia increase pain sensitivity ', Brain, vol. 141, no. 1, pp. 63-71 . https://doi.org/10.1093/brain/awx289

See Dickenson (doi:10.1093/brain/awx334) for a scientific commentary on this article.Inhibitory interneurons in the spinal cord use glycine and GABA for fast inhibitory neurotransmission. While there is abundant research on these inhibitory pain path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9accd7e9b5ce4ee279a1d4f33055a86
https://boris.unibe.ch/106654/7/awx289.pdf