Zobrazeno 1 - 10
of 276
pro vyhledávání: '"Vugler, A."'
Autor:
Alexander Vugler, James O’connell, Mai Anh Nguyen, Dietmar Weitz, Thomas Leeuw, Elizabeth Hickford, Alexander Verbitsky, Xiaoyou Ying, Markus Rehberg, Bruce Carrington, Mark Merriman, Andrew Moss, Jean-Marie Nicolas, Phil Stanley, Sara Wright, Tim Bourne, Yann Foricher, Zhaoning Zhu, Daniel Brookings, Helen Horsley, Jag Heer, Laurent Schio, Matthias Herrmann, Srinivas Rao, Markus Kohlmann, Peter Florian
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/7c28a2cfd57b43f5bbbad3d413464f30
Autor:
Alexander Vugler, James O’Connell, Mai Anh Nguyen, Dietmar Weitz, Thomas Leeuw, Elizabeth Hickford, Alexander Verbitsky, Xiaoyou Ying, Markus Rehberg, Bruce Carrington, Mark Merriman, Andrew Moss, Jean-Marie Nicholas, Phil Stanley, Sara Wright, Tim Bourne, Yann Foricher, Zhaoning Zhu, Daniel Brookings, Helen Horsley, Jag Heer, Laurent Schio, Matthias Herrmann, Srinivas Rao, Markus Kohlmann, Peter Florian
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Tumor necrosis factor (TNF) is a pleiotropic cytokine belonging to a family of trimeric proteins with both proinflammatory and immunoregulatory functions. TNF is a key mediator in autoimmune diseases and during the last couple of decades several biol
Externí odkaz:
https://doaj.org/article/1ee03f08f53b498dba01c240aad2ca37
Autor:
Vugler, Alexander, O’Connell, James, Nguyen, Mai Anh, Weitz, Dietmar, Leeuw, Thomas, Hickford, Elizabeth, Verbitsky, Alexander, Xiaoyou Ying, Rehberg, Markus, Carrington, Bruce, Merriman, Mark, Moss, Andrew, Nicholas, Jean-Marie, Stanley, Phil, Wright, Sara, Bourne, Tim, Foricher, Yann, Zhaoning Zhu, Brookings, Daniel, Horsley, Helen
Publikováno v:
Frontiers in Pharmacology; 2024, p1-17, 17p
Autor:
James O’Connell, John Porter, Boris Kroeplien, Tim Norman, Stephen Rapecki, Rachel Davis, David McMillan, Tracy Arakaki, Alex Burgin, David Fox III, Tom Ceska, Fabien Lecomte, Alison Maloney, Alex Vugler, Bruce Carrington, Benjamin P Cossins, Tim Bourne, Alastair Lawson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
While biologics have been successfully applied in TNF antagonist treatments, there are no clinically approved small molecules that target TNF. Here, the authors discover potent small molecule inhibitors of TNF, elucidate their molecular mechanism, an
Externí odkaz:
https://doaj.org/article/cd8aea08c83948d3a69fc5302494dedc
Autor:
Karen Eastlake, Weixin Wang, Hari Jayaram, Celia Murray‐Dunning, Amanda J. F. Carr, Conor M. Ramsden, Anthony Vugler, Katrina Gore, Nadine Clemo, Mark Stewart, Pete Coffey, Peng T. Khaw, G. Astrid Limb
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 8, Pp 775-784 (2019)
Abstract Glaucoma is one of the leading causes of blindness, and there is an ongoing need for new therapies. Recent studies indicate that cell transplantation using Müller glia may be beneficial, but there is a need for novel sources of cells to pro
Externí odkaz:
https://doaj.org/article/3318628640d742c6b2a42b2b510967aa
Autor:
Dulla, Kalyan, Aguila, Monica, Lane, Amelia, Jovanovic, Katarina, Parfitt, David A., Schulkens, Iris, Chan, Hee Lam, Schmidt, Iris, Beumer, Wouter, Vorthoren, Lars, Collin, Rob W.J., Garanto, Alejandro, Duijkers, Lonneke, Brugulat-Panes, Anna, Semo, Ma’ayan, Vugler, Anthony A., Biasutto, Patricia, Adamson, Peter, Cheetham, Michael E.
Publikováno v:
In Molecular Therapy - Nucleic Acids 7 September 2018 12:730-740
Antisense Therapy for a Common Corneal Dystrophy Ameliorates TCF4 Repeat Expansion-Mediated Toxicity
Autor:
Zarouchlioti, Christina, Sanchez-Pintado, Beatriz, Hafford Tear, Nathaniel J., Klein, Pontus, Liskova, Petra, Dulla, Kalyan, Semo, Ma’ayan, Vugler, Anthony A., Muthusamy, Kirithika, Dudakova, Lubica, Levis, Hannah J., Skalicka, Pavlina, Hysi, Pirro, Cheetham, Michael E., Tuft, Stephen J., Adamson, Peter, Hardcastle, Alison J., Davidson, Alice E.
Publikováno v:
In The American Journal of Human Genetics 5 April 2018 102(4):528-539
Autor:
Kalyan Dulla, Monica Aguila, Amelia Lane, Katarina Jovanovic, David A. Parfitt, Iris Schulkens, Hee Lam Chan, Iris Schmidt, Wouter Beumer, Lars Vorthoren, Rob W.J. Collin, Alejandro Garanto, Lonneke Duijkers, Anna Brugulat-Panes, Ma’ayan Semo, Anthony A. Vugler, Patricia Biasutto, Peter Adamson, Michael E. Cheetham
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 730-740 (2018)
Leber congenital amaurosis type 10 (LCA10) is a severe inherited retinal dystrophy associated with mutations in CEP290. The deep intronic c.2991+1655A>G mutation in CEP290 is the most common mutation in LCA10 individuals and represents an ideal targe
Externí odkaz:
https://doaj.org/article/b75a727e464a462186e85d15a2057aba
Akademický článek
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Autor:
Vugler, A., Semo, M., Ortín-Martínez, A., Rojanasakul, A., Nommiste, B., Valiente-Soriano, F.J., García-Ayuso, D., Coffey, P., Vidal-Sanz, M., Gias, C.
Publikováno v:
In Neuroscience 12 February 2015 286:60-78