RIP1 inhibition protects retinal ganglion cells in glaucoma models of ocular injury.

Autor: Kim BK; Department of Ophthalmology Discovery, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.; Institute of Chemical Sciences and Engineering (ISIC), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Goncharov T; Department of Immunology Discovery, Genentech, 1 DNA Way, South San Francisco, CA, USA., Archaimbault SA; Department of Ophthalmology Discovery, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland., Roudnicky F; Therapeutic Modalities, Pharmaceutical Research and Early Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland., Webster JD; Department of Pathology, Genentech, 1 DNA Way, South San Francisco, CA, USA., Westenskow PD; Department of Ophthalmology Discovery, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland., Vucic D; Department of Immunology Discovery, Genentech, 1 DNA Way, South San Francisco, CA, USA. domagoj@gene.com.

Publikováno v: Cell death and differentiation [Cell Death Differ] 2024 Oct 24. Date of Electronic Publication: 2024 Oct 24.

Association of intestinal inflammation and permeability markers with clinical manifestations of Parkinson's disease.

Autor: Rajkovaca Latic I; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, 31 000 Osijek, Croatia; Department of Gastroenterology and Endocrinology, Dr.Josip Bencevic General Hospital, Andrije Stampara 42, 35 000, Slavonski Brod, Croatia. Electronic address: ines.rajkovaca@gmail.com., Popovic Z; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, 31 000 Osijek, Croatia; Department of Neurology, Osijek University Hospital Center, Josipa Huttlera 4, 31 000, Osijek, Croatia., Mijatovic K; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, 31 000 Osijek, Croatia; Department of Nucelar Medicine, Osijek University Hospital Center, Josipa Huttlera 4, 31 000, Osijek, Croatia., Sahinovic I; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, 31 000 Osijek, Croatia; Department of Clinical Laboratory Diagnostics, Osijek University Hospital Center, Josipa Huttlera 4, 31 000, Osijek, Croatia., Pekic V; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, 31 000 Osijek, Croatia; Department of Neurology, Osijek University Hospital Center, Josipa Huttlera 4, 31 000, Osijek, Croatia., Vucic D; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, 31 000, Osijek, Croatia; Department of Cardiology, Dr.Josip Bencevic General Hospital, Andrije Stampara 42, 35 000, Slavonski Brod, Croatia., Cosic V; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, 31 000, Osijek, Croatia., Miskic B; Department of Gastroenterology and Endocrinology, Dr.Josip Bencevic General Hospital, Andrije Stampara 42, 35 000, Slavonski Brod, Croatia; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, 31 000, Osijek, Croatia., Tomic S; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, 31 000 Osijek, Croatia; Department of Neurology, Osijek University Hospital Center, Josipa Huttlera 4, 31 000, Osijek, Croatia.

Publikováno v: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2024 Jun; Vol. 123, pp. 106948. Date of Electronic Publication: 2024 Mar 27.

Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2.

Autor: Goncharov T; Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA 94080, USA.; Department of Immunology Discovery, Genentech, South San Francisco, CA 94080, USA., Kőműves LG; Department of Pathology, Genentech, South San Francisco, CA 94080, USA., Kist M; Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA 94080, USA.; Department of Immunology Discovery, Genentech, South San Francisco, CA 94080, USA., Castellanos ER; Department of Structural Biology, Genentech, South San Francisco, CA 94080, USA., Witt A; Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA 94080, USA.; Department of Immunology Discovery, Genentech, South San Francisco, CA 94080, USA., Fedorova AV; Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA 94080, USA., Izrael-Tomasevic A; Department of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA 94080, USA., Yu K; Department of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA 94080, USA., Keir M; Department of Human Pathobiology and OMNI Reverse Translation, Genentech, South San Francisco, CA 94080, USA., Matsumoto ML; Department of Structural Biology, Genentech, South San Francisco, CA 94080, USA., Vucic D; Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA 94080, USA.; Department of Immunology Discovery, Genentech, South San Francisco, CA 94080, USA.

Publikováno v: Science signaling [Sci Signal] 2024 Jan 16; Vol. 17 (819), pp. eabn1101. Date of Electronic Publication: 2024 Jan 16.

Apoptotic cell death in disease-Current understanding of the NCCD 2023.

Autor: Vitale I; IIGM - Italian Institute for Genomic Medicine, c/o IRCSS Candiolo, Torino, Italy. iliovit@gmail.com.; Candiolo Cancer Institute, FPO -IRCCS, Candiolo, Italy. iliovit@gmail.com., Pietrocola F; Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden., Guilbaud E; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA., Aaronson SA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Abrams JM; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Adam D; Institut für Immunologie, Kiel University, Kiel, Germany., Agostini M; Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy., Agostinis P; Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.; VIB Center for Cancer Biology, Leuven, Belgium., Alnemri ES; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA., Altucci L; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.; BIOGEM, Avellino, Italy., Amelio I; Division of Systems Toxicology, Department of Biology, University of Konstanz, Konstanz, Germany., Andrews DW; Sunnybrook Research Institute, Toronto, ON, Canada.; Departments of Biochemistry and Medical Biophysics, University of Toronto, Toronto, ON, Canada., Aqeilan RI; Hebrew University of Jerusalem, Lautenberg Center for Immunology & Cancer Research, Institute for Medical Research Israel-Canada (IMRIC), Faculty of Medicine, Jerusalem, Israel., Arama E; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel., Baehrecke EH; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Balachandran S; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Bano D; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany., Barlev NA; Department of Biomedicine, Nazarbayev University School of Medicine, Astana, Kazakhstan., Bartek J; Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden.; Danish Cancer Society Research Center, Copenhagen, Denmark., Bazan NG; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, USA., Becker C; Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany., Bernassola F; Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy., Bertrand MJM; VIB-UGent Center for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Bianchi ME; Università Vita-Salute San Raffaele, School of Medicine, Milan, Italy and Ospedale San Raffaele IRCSS, Milan, Italy., Blagosklonny MV; Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Blander JM; Department of Medicine, Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, New York, NY, USA., Blandino G; IRCSS Regina Elena National Cancer Institute, Rome, Italy., Blomgren K; Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.; Pediatric Hematology and Oncology, Karolinska University Hospital, Stockholm, Sweden., Borner C; Institute of Molecular Medicine and Cell Research, Medical Faculty, Albert Ludwigs University of Freiburg, Freiburg, Germany., Bortner CD; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, Durham, NC, USA., Bove P; Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy., Boya P; Centro de Investigaciones Biologicas Margarita Salas, CSIC, Madrid, Spain., Brenner C; Université Paris-Saclay, CNRS, Institut Gustave Roussy, Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques, Villejuif, France., Broz P; Department of Immunobiology, University of Lausanne, Epalinges, Vaud, Switzerland., Brunner T; Department of Biology, University of Konstanz, Konstanz, Germany., Damgaard RB; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Calin GA; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Campanella M; Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, London, UK.; UCL Consortium for Mitochondrial Research, London, UK.; Department of Biology, University of Rome Tor Vergata, Rome, Italy., Candi E; Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy., Carbone M; Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI, USA., Carmona-Gutierrez D; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria., Cecconi F; Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Università Cattolica del Sacro Cuore, Rome, Italy., Chan FK; Department of Immunology, Duke University School of Medicine, Durham, NC, USA., Chen GQ; State Key Lab of Oncogene and its related gene, Ren-Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Chen Q; College of Life Sciences, Nankai University, Tianjin, China., Chen YH; Shenzhen Institute of Advanced Technology (SIAT), Shenzhen, Guangdong, China., Cheng EH; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chipuk JE; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cidlowski JA; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, Durham, NC, USA., Ciechanover A; The Technion-Integrated Cancer Center, The Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Ciliberto G; IRCSS Regina Elena National Cancer Institute, Rome, Italy., Conrad M; Helmholtz Munich, Institute of Metabolism and Cell Death, Neuherberg, Germany., Cubillos-Ruiz JR; Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA., Czabotar PE; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia., D'Angiolella V; Department of Oncology, University of Oxford, Oxford, UK., Daugaard M; Department of Urologic Sciences, Vancouver Prostate Centre, Vancouver, BC, Canada., Dawson TM; Institute for Cell Engineering and the Departments of Neurology, Neuroscience and Pharmacology & Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Dawson VL; Institute for Cell Engineering and the Departments of Neurology, Neuroscience and Pharmacology & Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., De Maria R; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Università Cattolica del Sacro Cuore, Rome, Italy., De Strooper B; VIB Centre for Brain & Disease Research, Leuven, Belgium.; Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium.; The Francis Crick Institute, London, UK.; UK Dementia Research Institute at UCL, University College London, London, UK., Debatin KM; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany., Deberardinis RJ; Howard Hughes Medical Institute and Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA., Degterev A; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA., Del Sal G; Department of Life Sciences, University of Trieste, Trieste, Italy.; International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park-Padriciano, Trieste, Italy.; IFOM ETS, the AIRC Institute of Molecular Oncology, Milan, Italy., Deshmukh M; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, USA., Di Virgilio F; Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Diederich M; College of Pharmacy, Seoul National University, Seoul, South Korea., Dixon SJ; Department of Biology, Stanford University, Stanford, CA, USA., Dynlacht BD; Department of Pathology, New York University Cancer Institute, New York University School of Medicine, New York, NY, USA., El-Deiry WS; Division of Hematology/Oncology, Brown University and the Lifespan Cancer Institute, Providence, RI, USA.; Legorreta Cancer Center at Brown University, The Warren Alpert Medical School, Brown University, Providence, RI, USA.; Department of Pathology and Laboratory Medicine, The Warren Alpert Medical School, Brown University, Providence, RI, USA., Elrod JW; Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA., Engeland K; Molecular Oncology, University of Leipzig, Leipzig, Germany., Fimia GM; Department of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases 'L. Spallanzani' IRCCS, Rome, Italy.; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Galassi C; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA., Ganini C; Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.; Biochemistry Laboratory, Dermopatic Institute of Immaculate (IDI) IRCCS, Rome, Italy., Garcia-Saez AJ; CECAD, Institute of Genetics, University of Cologne, Cologne, Germany., Garg AD; Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium., Garrido C; INSERM, UMR, 1231, Dijon, France.; Faculty of Medicine, Université de Bourgogne Franche-Comté, Dijon, France.; Anti-cancer Center Georges-François Leclerc, Dijon, France., Gavathiotis E; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.; Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.; Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, New York, NY, USA.; Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, New York, NY, USA., Gerlic M; Department of Clinical Microbiology and Immunology, Sackler school of Medicine, Tel Aviv university, Tel Aviv, Israel., Ghosh S; Department of Neurology and Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA., Green DR; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA., Greene LA; Department of Pathology and Cell Biology, Columbia University, New York, NY, USA., Gronemeyer H; Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, U1258, Illkirch, France.; Université de Strasbourg, Illkirch, France., Häcker G; Faculty of Medicine, Institute of Medical Microbiology and Hygiene, Medical Center, University of Freiburg, Freiburg, Germany.; BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany., Hajnóczky G; MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA., Hardwick JM; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Departments of Molecular Microbiology and Immunology, Pharmacology, Oncology and Neurology, Johns Hopkins Bloomberg School of Public Health and School of Medicine, Baltimore, MD, USA., Haupt Y; VITTAIL Ltd, Melbourne, VIC, Australia.; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., He S; Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu, China., Heery DM; School of Pharmacy, University of Nottingham, Nottingham, UK., Hengartner MO; ETH Board, Zurich, Switzerland., Hetz C; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.; Center for Molecular Studies of the Cell, Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.; Buck Institute for Research on Aging, Novato, CA, USA., Hildeman DA; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Ichijo H; Laboratory of Cell Signaling, The University of Tokyo, Tokyo, Japan., Inoue S; National Cancer Center Research Institute, Tokyo, Japan., Jäättelä M; Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, Copenhagen, Denmark.; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Janic A; Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain., Joseph B; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Jost PJ; Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Kanneganti TD; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA., Karin M; Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego, San Diego, CA, USA., Kashkar H; CECAD Research Center, Institute for Molecular Immunology, University of Cologne, Cologne, Germany., Kaufmann T; Institute of Pharmacology, University of Bern, Bern, Switzerland., Kelly GL; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia., Kepp O; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France.; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France., Kimchi A; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel., Kitsis RN; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.; Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.; Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.; Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, New York, NY, USA., Klionsky DJ; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA., Kluck R; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia., Krysko DV; Cell Death Investigation and Therapy Lab, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Kulms D; Department of Dermatology, Experimental Dermatology, TU-Dresden, Dresden, Germany.; National Center for Tumor Diseases Dresden, TU-Dresden, Dresden, Germany., Kumar S; Centre for Cancer Biology, University of South Australia, Adelaide, SA, Australia.; Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia., Lavandero S; Universidad de Chile, Facultad Ciencias Quimicas y Farmaceuticas & Facultad Medicina, Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile.; Department of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX, USA., Lavrik IN; Translational Inflammation Research, Medical Faculty, Otto von Guericke University, Magdeburg, Germany., Lemasters JJ; Departments of Drug Discovery & Biomedical Sciences and Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA., Liccardi G; Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany., Linkermann A; Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Biotechnology Center, Technische Universität Dresden, Dresden, Germany., Lipton SA; Neurodegeneration New Medicines Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA, USA.; Department of Neurology, Yale School of Medicine, New Haven, CT, USA., Lockshin RA; Department of Biology, Queens College of the City University of New York, Flushing, NY, USA.; St. John's University, Jamaica, NY, USA., López-Otín C; Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain., Luedde T; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Heinrich Heine University, Duesseldorf, Germany., MacFarlane M; Medical Research Council Toxicology Unit, University of Cambridge, Cambridge, UK., Madeo F; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.; BioTechMed Graz, Graz, Austria.; Field of Excellence BioHealth - University of Graz, Graz, Austria., Malorni W; Center for Global Health, Università Cattolica del Sacro Cuore, Rome, Italy., Manic G; IIGM - Italian Institute for Genomic Medicine, c/o IRCSS Candiolo, Torino, Italy.; Candiolo Cancer Institute, FPO -IRCCS, Candiolo, Italy., Mantovani R; Dipartimento di Bioscienze, Università degli Studi di Milano, Milano, Italy., Marchi S; Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy., Marine JC; VIB Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Martin SJ; Department of Genetics, Trinity College, Dublin, 2, Ireland., Martinou JC; Department of Cell Biology, Faculty of Sciences, University of Geneva, Geneva, Switzerland., Mastroberardino PG; Department of Molecular Genetics, Rotterdam, the Netherlands.; IFOM-ETS The AIRC Institute for Molecular Oncology, Milan, Italy.; Department of Life, Health, and Environmental Sciences, University of L'Aquila, L'Aquila, Italy., Medema JP; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Mehlen P; Apoptosis, Cancer, and Development Laboratory, Equipe labellisée 'La Ligue', LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Université de Lyon, Université Claude Bernard Lyon1, Lyon, France., Meier P; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Melino G; Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy., Melino S; Department of Chemical Science and Technologies, University of Rome Tor Vergata, Rome, Italy., Miao EA; Department of Immunology, Duke University School of Medicine, Durham, NC, USA., Moll UM; Department of Pathology and Stony Brook Cancer Center, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Muñoz-Pinedo C; Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Spain., Murphy DJ; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; Cancer Research UK Beatson Institute, Glasgow, UK., Niklison-Chirou MV; Department of Pharmacy & Pharmacology, Centre for Therapeutic Innovation, University of Bath, Bath, UK., Novelli F; Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI, USA., Núñez G; Department of Pathology and Rogel Cancer Center, The University of Michigan, Ann Arbor, MI, USA., Oberst A; Department of Immunology, University of Washington, Seattle, WA, USA., Ofengeim D; Rare and Neuroscience Therapeutic Area, Sanofi, Cambridge, MA, USA., Opferman JT; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Oren M; Department of Molecular Cell Biology, The Weizmann Institute, Rehovot, Israel., Pagano M; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine and Howard Hughes Medical Institute, New York, NY, USA., Panaretakis T; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of GU Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA., Pasparakis M; CECAD, Institute of Genetics, University of Cologne, Cologne, Germany., Penninger JM; IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.; Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, Canada., Pentimalli F; Department of Medicine and Surgery, LUM University, Casamassima, Bari, Italy., Pereira DM; REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal., Pervaiz S; Department of Physiology, YLL School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research (N2CR), National University of Singapore, Singapore, Singapore.; National University Cancer Institute, NUHS, Singapore, Singapore.; ISEP, NUS Graduate School, National University of Singapore, Singapore, Singapore., Peter ME; Department of Medicine, Division Hematology/Oncology, Northwestern University, Chicago, IL, USA., Pinton P; Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Porta G; Center of Genomic Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy., Prehn JHM; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences, Dublin 2, Ireland., Puthalakath H; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia., Rabinovich GA; Laboratorio de Glicomedicina. Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina., Rajalingam K; Cell Biology Unit, University Medical Center Mainz, Mainz, Germany., Ravichandran KS; VIB-UGent Center for Inflammation Research, Ghent, Belgium.; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Cell Clearance, Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA., Rehm M; Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany., Ricci JE; Université Côte d'Azur, INSERM, C3M, Equipe labellisée Ligue Contre le Cancer, Nice, France., Rizzuto R; Department of Biomedical Sciences, University of Padua, Padua, Italy., Robinson N; Centre for Cancer Biology, University of South Australia, Adelaide, SA, Australia., Rodrigues CMP; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal., Rotblat B; Department of Life sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.; The NIBN, Beer Sheva, Israel., Rothlin CV; Department of Immunobiology and Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA., Rubinsztein DC; Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge Institute for Medical Research, Cambridge, UK., Rudel T; Microbiology Biocentre, University of Würzburg, Würzburg, Germany., Rufini A; Dipartimento di Bioscienze, Università degli Studi di Milano, Milano, Italy.; University of Leicester, Leicester Cancer Research Centre, Leicester, UK., Ryan KM; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; Cancer Research UK Beatson Institute, Glasgow, UK., Sarosiek KA; John B. Little Center for Radiation Sciences, Harvard School of Public Health, Boston, MA, USA.; Department of Systems Biology, Lab of Systems Pharmacology, Harvard Program in Therapeutics Science, Harvard Medical School, Boston, MA, USA.; Department of Environmental Health, Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, MA, USA., Sawa A; Johns Hopkins Schizophrenia Center, Johns Hopkins University, Baltimore, MD, USA., Sayan E; Faculty of Medicine, Cancer Sciences Unit, University of Southampton, Southampton, UK., Schroder K; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia., Scorrano L; Department of Biology, University of Padua, Padua, Italy.; Veneto Institute of Molecular Medicine, Padua, Italy., Sesti F; Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, NJ, USA., Shao F; National Institute of Biological Sciences, Beijing, PR China., Shi Y; Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.; The Third Affiliated Hospital of Soochow University and State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University, Suzhou, Jiangsu, China.; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China., Sica GS; Department of Surgical Science, University Tor Vergata, Rome, Italy., Silke J; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia., Simon HU; Institute of Pharmacology, University of Bern, Bern, Switzerland.; Institute of Biochemistry, Brandenburg Medical School, Neuruppin, Germany., Sistigu A; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy., Stephanou A; European University Cyprus, School of Medicine, Nicosia, Cyprus., Stockwell BR; Department of Biological Sciences and Department of Chemistry, Columbia University, New York, NY, USA., Strapazzon F; IRCCS Fondazione Santa Lucia, Rome, Italy.; Univ Lyon, Univ Lyon 1, Physiopathologie et Génétique du Neurone et du Muscle, UMR5261, U1315, Institut NeuroMyogène CNRS, INSERM, Lyon, France., Strasser A; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia., Sun L; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China., Sun E; Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China., Sun Q; Laboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.; Research Unit of Cell Death Mechanism, 2021RU008, Chinese Academy of Medical Science, Beijing, China., Szabadkai G; Department of Biomedical Sciences, University of Padua, Padua, Italy.; Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, London, UK., Tait SWG; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; Cancer Research UK Beatson Institute, Glasgow, UK., Tang D; Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Tavernarakis N; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece.; Department of Basic Sciences, School of Medicine, University of Crete, Heraklion, Crete, Greece., Troy CM; Departments of Pathology & Cell Biology and Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Turk B; Department of Biochemistry and Molecular and Structural Biology, J. Stefan Institute, Ljubljana, Slovenia.; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia., Urbano N; Department of Oncohaematology, University of Rome Tor Vergata, TOR, Rome, Italy., Vandenabeele P; VIB-UGent Center for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Methusalem Program, Ghent University, Ghent, Belgium., Vanden Berghe T; VIB-UGent Center for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Infla-Med Centre of Excellence, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Vander Heiden MG; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Vanderluit JL; Division of BioMedical Sciences, Memorial University, St. John's, NL, Canada., Verkhratsky A; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.; Achucarro Center for Neuroscience, IKERBASQUE, Bilbao, Spain.; School of Forensic Medicine, China Medical University, Shenyang, China.; State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania., Villunger A; Institute for Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.; The Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences (OeAW), Vienna, Austria.; The Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD), Vienna, Austria., von Karstedt S; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Voss AK; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia., Vousden KH; The Francis Crick Institute, London, UK., Vucic D; Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA, USA., Vuri D; Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy., Wagner EF; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Walczak H; Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK., Wallach D; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Wang R; Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA., Wang Y; Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China., Weber A; University of Zurich and University Hospital Zurich, Department of Pathology and Molecular Pathology, Zurich, Switzerland.; University of Zurich, Institute of Molecular Cancer Research, Zurich, Switzerland., Wood W; Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Yamazaki T; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA., Yang HT; Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China., Zakeri Z; Queens College and Graduate Center, City University of New York, Flushing, NY, USA., Zawacka-Pankau JE; Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden.; Department of Biochemistry, Laboratory of Biophysics and p53 protein biology, Medical University of Warsaw, Warsaw, Poland., Zhang L; Department of Pharmacology & Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Zhang H; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China., Zhivotovsky B; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia., Zhou W; Laboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.; Research Unit of Cell Death Mechanism, 2021RU008, Chinese Academy of Medical Science, Beijing, China., Piacentini M; Department of Biology, University of Rome Tor Vergata, Rome, Italy.; National Institute for Infectious Diseases IRCCS 'Lazzaro Spallanzani', Rome, Italy., Kroemer G; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France.; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.; Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France., Galluzzi L; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA. deadoc80@gmail.com.; Sandra and Edward Meyer Cancer Center, New York, NY, USA. deadoc80@gmail.com.; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA. deadoc80@gmail.com.

Publikováno v: Cell death and differentiation [Cell Death Differ] 2023 May; Vol. 30 (5), pp. 1097-1154. Date of Electronic Publication: 2023 Apr 26.

cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation.

Autor: Schorn F; Faculty of Medicine and University Hospital of Cologne, Institute for Molecular Immunology, University of Cologne, Cologne, Germany., Werthenbach JP; Faculty of Medicine and University Hospital of Cologne, Institute for Molecular Immunology, University of Cologne, Cologne, Germany., Hoffmann M; Faculty of Medicine and University Hospital of Cologne, Institute for Molecular Immunology, University of Cologne, Cologne, Germany., Daoud M; Faculty of Medicine and University Hospital of Cologne, Institute for Molecular Immunology, University of Cologne, Cologne, Germany., Stachelscheid J; Faculty of Medicine and University Hospital of Cologne, Institute for Molecular Immunology, University of Cologne, Cologne, Germany., Schiffmann LM; Faculty of Medicine and University Hospital of Cologne, Department of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany., Hildebrandt X; Faculty of Medicine and University Hospital of Cologne, Department of Translational Genomics, University of Cologne, Cologne, Germany., Lyu SI; Faculty of Medicine and University Hospital of Cologne, Institute of Pathology and Center for Integrated Oncology (CIO) Cologne Bonn, University of Cologne, Cologne, Germany., Peltzer N; Faculty of Medicine and University Hospital of Cologne, Department of Translational Genomics, University of Cologne, Cologne, Germany., Quaas A; Faculty of Medicine and University Hospital of Cologne, Institute of Pathology and Center for Integrated Oncology (CIO) Cologne Bonn, University of Cologne, Cologne, Germany., Vucic D; Department of Immunology Discovery, Genentech, South San Francisco, CA, USA., Silke J; The Walter and Eliza Hall Institute for Medical Research, Melbourne, Vic., Australia., Pasparakis M; Institute for Genetics, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Kashkar H; Faculty of Medicine and University Hospital of Cologne, Institute for Molecular Immunology, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Publikováno v: The EMBO journal [EMBO J] 2023 Nov 15; Vol. 42 (22), pp. e113614. Date of Electronic Publication: 2023 Oct 04.