Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Vu Van Ma"'
Autor:
Jeffrey Clarine, Qingyian Liu, Beth D. Youngblood, Chester Chenguang Yuan, Michelle Horner, James Brown, Jian J. Chen, Michael D. Bartberger, Vu Van Ma, Matthew R. Kaller, Carl D. Davis, Maosheng Zhang, Thomas T. Nguyen, Narender R. Gavva, Scott Harried, Sonya G. Lehto, Jennifer R. Allen, Holger Monenschein, Daniel B. Horne, Vijay Keshav Gore, Wenge Zhong, Kaustav Biswas
Publikováno v:
Journal of medicinal chemistry. 61(18)
Transient-receptor-potential melastatin 8 (TRPM8), the predominant mammalian cold-temperature thermosensor, is a nonselective cation channel expressed in a subpopulation of sensory neurons in the peripheral nervous system, including nerve circuitry i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c32a8bd8200356c5984cf6c6b54e8a8
https://pubmed.ncbi.nlm.nih.gov/30148953
https://pubmed.ncbi.nlm.nih.gov/30148953
Autor:
Sonya G. Lehto, Weiya Wang, Narender R. Gavva, Hong Deng, Mark H. Norman, Lana Klionsky, Nobuko Nishimura, Brad Youngblood, Phi Tang, Vu Van Ma, Jiyun Chen, Vijay Keshav Gore, Michael D. Bartberger, Nuria A. Tamayo, Tiffany L. Correll, Yunxin Bo
Publikováno v:
Journal of Medicinal Chemistry. 55:1593-1611
The transient receptor potential melastatin type 8 (TRPM8) is a nonselective cation channel primarily expressed in a subpopulation of sensory neurons that can be activated by a wide range of stimuli, including menthol, icilin, and cold temperatures (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1beaabfc08eed8ea8dfb711873a8ed34
https://doi.org/10.1021/jm2013634
https://doi.org/10.1021/jm2013634
Autor:
David C. Immke, Mark H. Norman, Vu Van Ma, Ruoyuan Yin, Elizabeth M. Doherty, Vijay Keshav Gore, Joe Ligutti
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3573-3578
The membrane bound large-conductance, calcium-activated potassium channel (BKCa) is an important regulator of neuronal activity. Here we describe the identification and structure-activity relationship of a novel class of potent tetrahydroquinoline BK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ec2aa172b1a3114de4128928e20321
https://doi.org/10.1016/j.bmcl.2010.04.125
https://doi.org/10.1016/j.bmcl.2010.04.125
Autor:
Narender R. Gavva, Vijay Keshav Gore, Mark H. Norman, Rami Tamir, James J. S. Treanor, Vu Van Ma
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5825-5830
A novel series of 4,5-biarylimidazoles as TRPV1 antagonists were designed based on the previously reported 4,6-disubstituted benzimidazole series. The analogs were evaluated for their ability to block capsaicin- or acid-induced calcium influx in TRPV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff1c6f594460d28366f4c460ac6cfec
https://doi.org/10.1016/j.bmcl.2007.08.044
https://doi.org/10.1016/j.bmcl.2007.08.044
Autor:
Vinod F. Patel, Timothy Powers, Michael D. Bartberger, Ted Judd, Ryan White, Stephen J. Wood, Ana Elena Minatti, Stephen Hitchcock, Vijay Keshav Gore, Wenge Zhong, Hugo M. Vargas, Jason Brooks Human, Kui Chen, Steven Vonderfecht, Robert T. Fremeau, Robert T. Dunn, James Brown, Patricia Lopez, Qingyian Liu, Vu Van Ma, Nancy E. Everds, Matthew Weiss, Charles Kreiman, Oleg Epstein, May Xue, Chester Chenguang Yuan, Jonathan Werner, Alan C. Cheng, Jian J. Chen, Albert Amegadzie, Paul H. Wen, Yuan Cheng, Douglas A. Whittington, Wenyuan Qian, Isaac E. Marx, Thomas Dineen, Dean Hickman
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(4)
The β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is one of the most hotly pursued targets for the treatment of Alzheimer’s disease. We used a structure- and property-based drug design approach to identify 2-aminooxazoline 3-aza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3503e3152a8ed1278e105f059b963c2
https://pubmed.ncbi.nlm.nih.gov/25613679
https://pubmed.ncbi.nlm.nih.gov/25613679
Autor:
Vu Van Ma, Maosheng Zhang, Nuria A. Tamayo, Vijay Keshav Gore, Weiya Wang, Phi Tang, Holger Monenschein, Daniel B. Horne, Mark H. Norman, Michael D. Bartberger, Yunxin Bo, Jeffrey Clarine, Thomas T. Nguyen, Carl Davis, Beth D. Youngblood, Matthew R. Kaller, Sonya G. Lehto, Narender R. Gavva, Nobuko Nishimura
Publikováno v:
Journal of medicinal chemistry. 57(7)
Transient receptor potential melastatin 8 (TRPM8) is a nonselective cation channel expressed in a subpopulation of sensory neurons in the peripheral nervous system. TRPM8 is the predominant mammalian cold temperature thermosensor and is activated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31259e241c7b92b3f659ee0304d6bff2
https://pubmed.ncbi.nlm.nih.gov/24597733
https://pubmed.ncbi.nlm.nih.gov/24597733
Publikováno v:
Tetrahedron Letters. 42:4963-4968
The novel solution-phase syntheses of arrays of biologically relevant indazolinones, benzazepines and benzoxazepines, utilizing multi-component condensation (MCC)/SNAr methodology is reported. Reaction of commercially available 2-fluoro-5-nitrobenzoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d3cc6a85e22fac1e52ac6328396c8d1
https://doi.org/10.1016/s0040-4039(01)00920-0
https://doi.org/10.1016/s0040-4039(01)00920-0
Publikováno v:
Tetrahedron Letters. 42:4959-4962
The novel solution-phase synthesis of an array of biologically relevant benzimidazoles in a simple two-step procedure is revealed. Transformations are carried out in excellent yield by condensation of mono-Boc protected ortho-phenylene diamine and su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2328d2771a7f6175d12fc8979838d5d
https://doi.org/10.1016/s0040-4039(01)00919-4
https://doi.org/10.1016/s0040-4039(01)00919-4
Publikováno v:
ChemInform. 32
The novel solution-phase synthesis of an array of biologically relevant benzimidazoles in a simple two-step procedure is revealed. Transformations are carried out in excellent yield by condensation of mono-Boc protected ortho-phenylene diamine and su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49b383c29153b8091cec25efab34a6bb
https://doi.org/10.1002/chin.200140120
https://doi.org/10.1002/chin.200140120
Publikováno v:
ChemInform. 32
The novel solution-phase syntheses of arrays of biologically relevant indazolinones, benzazepines and benzoxazepines, utilizing multi-component condensation (MCC)/SNAr methodology is reported. Reaction of commercially available 2-fluoro-5-nitrobenzoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8206d996f8904fae1b98d3dbb2139717
https://doi.org/10.1002/chin.200140095
https://doi.org/10.1002/chin.200140095