Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Vu Chi Truc"'
Autor:
Rossano Lucius T, Michael A. Schmidt, Vu Chi Truc, Jacob Albrecht, Andrew G. Lee, Xinhua Qian, Ehrlic Lo, Steven L. Goldberg, Emily A. Reiff, Jaan A. Pesti, Chao Hang, Kenneth J. Natalie, Animesh Goswami, Zhiwei Guo, Chenchi Wang
Publikováno v:
Organic Process Research & Development. 19:1317-1322
The process development and large scale synthesis for the β-hydroxyamino amide 1 is described. The route evolved from a multistep sequence utilizing a classical resolution to a two-step enantioselective process involving an enzyme-catalyzed aldol re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e78e620e78b1f8852562c1c09f2eda3c
https://doi.org/10.1021/acs.oprd.5b00192
https://doi.org/10.1021/acs.oprd.5b00192
Autor:
Zhiwei Guo, Animesh Goswami, Steven L. Goldberg, Kenneth J. Natalie, Vu Chi Truc, Chao Hang, Rossano Lucius T, Michael A. Schmidt, Andrew G. Lee, Ehrlic Lo, Yeung Y. Chan
Publikováno v:
Organic Process Research & Development. 19:1308-1316
The chiral β-hydroxy-α-amino acid, (2R,3S)-2-amino-3-hydroxy-3-(pyridin-4-yl)-propanoic acid, is a key intermediate in the synthesis of the API (2R,3S)-2-amino-3-hydroxy-3-(pyridin-4-yl)-1-(pyrrolidin-1-yl)propan-1-one, a developmental drug candida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb02e24fc17ba2492c2cb3e297aff494
https://doi.org/10.1021/acs.oprd.5b00191
https://doi.org/10.1021/acs.oprd.5b00191
Autor:
Chenchi Wang, Jianji Wang, Srinivas Tummala, David R. Kronenthal, Scott Jones, Antonio Ramirez, Robert E. Waltermire, Michael Lawler, Kolotuchin Sergei, Shailendra Bordawekar, Nian Liu, Laporte Thomas L, Yun K. Ye, Steven Chen, Vu Chi Truc
Publikováno v:
The Journal of organic chemistry. 79(13)
The synthesis of a key intermediate in the preparation of oral antidiabetic drug Saxagliptin is discussed with an emphasis on the challenges posed by the cyclopropanation of a dihydropyrrole. Kinetic studies on the cyclopropanation show an induction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b99ff3901dd02e32b2d0fbed547b0aa
https://pubmed.ncbi.nlm.nih.gov/24915024
https://pubmed.ncbi.nlm.nih.gov/24915024
Publikováno v:
Organic Syntheses
N(tert-Butyloxycarbonyl)pyrrolidi-2-one Super-Hydride N,N-Disiopropylethylamine Trifluoracetic anhydride 1-tert-Butoxycarbonyl-2,3-dihydropyrrole DMAP Keywords: cyclic enecarbamates; one-pot conversion; lactamols; intermediates; lactam carbamates; wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d13bfe5d20572ce8a41d768be9c0e2d9
https://doi.org/10.1002/0471264229.os085.08
https://doi.org/10.1002/0471264229.os085.08
Publikováno v:
ChemInform. 36
A general, practical and efficient one-pot synthesis of cyclic enecarbamates is described. The protocol proceeds via reduction of lactam carbamate with Super-Hydride ® , followed by in situ dehydration with trifluoroacetic anhydride (TFAA) and diiso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641c0f5c2cd7b3578033143729c0bbf0
https://doi.org/10.1002/chin.200538121
https://doi.org/10.1002/chin.200538121
Autor:
Jianji Wang, Jun Li, Vu Chi Truc, Robert P. Discordia, John A. Grosso, Polniaszek Richard P, Gerard A. Crispino
Publikováno v:
ChemInform. 34
Using LiHMDS as the base, a tandem amidation/Knoevenagel condensation of 2-aminobenzophenones with α-methylene esters or lactones gives 4-aryl-quinolin-2(1H)-ones in 65–96% yield. This method is mild, highly efficient, and amenable to scaleup.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643e9c61a85e684ad57111d67901058f
https://doi.org/10.1002/chin.200336115
https://doi.org/10.1002/chin.200336115
Akademický článek
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Autor:
Steven L. Goldberg, Animesh Goswami, Zhiwei Guo, Yeung Chan, Ehrlic T. Lo, Andrew Lee, Vu Chi Truc, Kenneth J. Natalie, Chao Hang, Lucius T. Rossano, Michael A. Schmidt
Publikováno v:
Organic Process Research & Development; Sep2015, Vol. 19 Issue 9, p1308-1316, 9p
Autor:
Michael A. Schmidt, Emily A. Reiff, Xinhua Qian, Chao Hang, Vu Chi Truc, Kenneth J. Natalie, Chenchi Wang, Jacob Albrecht, Andrew G. Lee, Ehrlic T. Lo, Zhiwei Guo, Animesh Goswami, Steven Goldberg, Jaan Pesti, Lucius T. Rossano
Publikováno v:
Organic Process Research & Development; Sep2015, Vol. 19 Issue 9, p1317-1322, 6p
Autor:
Don N. Harris, Joyce A. Reid, Martin F. Haslanger, Anders Hedberg, Dianne Garber, Jagabandhu Das, Wen Ching Han, Vu Chi Truc, Masami Nakane, Martin L. Ogletree, Hall Steven E
Publikováno v:
Journal of medicinal chemistry. 33(9)
A novel bicyclic prostaglandin analogue, [1S-[1 alpha, 2 alpha (Z), 3 alpha, 4 alpha]]-7-[3-[[[[(1- Oxoheptyl)amino]acetyl]amino]-methyl]-7-oxabicyclo[2.2.1]hept-2- yl]-5-heptenoic acid [-)-7) was found to be a potent and selective thromboxane A2 (Tx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b20cab806c041b070ec50e8ee2d5e7c
https://pubmed.ncbi.nlm.nih.gov/2391688
https://pubmed.ncbi.nlm.nih.gov/2391688