Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Vsevolod E. Kostrubsky"'
Autor:
Kristina K. Wolf, David J. Greenblatt, Steven A. Wrighton, Nadia Gorman, Brooke W. Walton-Strong, Frank J. Gonzalez, Qin Hao, Jacqueline F. Sinclair, Sheryl G. Wood, Elizabeth H. Jeffery, Peter R. Sinclair, Su X. Duan, Michael H. Court, Jenna L. Allard, Vsevolod E. Kostrubsky, Juliana G. Szakacs, Jane A. Hunt, Lisa L. von Moltke
Publikováno v:
Drug Metabolism and Disposition. 35:1223-1231
CYP2E1 is widely accepted as the sole form of cytochrome P450 responsible for alcohol-mediated increases in acetaminophen (APAP) hepatotoxicity. However, we previously found that alcohol [ethanol and isopentanol (EIP)] causes increases in APAP hepato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b40d44c01a5b83daca75eb458c75f9
https://doi.org/10.1124/dmd.107.014738
https://doi.org/10.1124/dmd.107.014738
Autor:
Juliana G. Szakacs, Vsevolod E. Kostrubsky, Jane A. Hunt, Sheryl G. Wood, William J. Bement, Kimberley A. O'Hara, Steven A. Wrighton, Judith M. Jacobs, Jenna L. Bement, Herbert C. Yohe, Tamar J. Kitzmiller, Peter R. Sinclair, Jacqueline F. Sinclair
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 290:G1269-G1279
The objective of this study was to determine whether Toll-like receptor 4 (TLR4) has a role in alcohol-mediated acetaminophen (APAP) hepatotoxicity. TLR4 is involved in the inflammatory response to endotoxin. Others have found that ethanol-mediated l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368730286c640345e09b8596508af62d
https://doi.org/10.1152/ajpgi.00239.2005
https://doi.org/10.1152/ajpgi.00239.2005
Autor:
Hongbo Cai, Jacqueline F. Sinclair, Stephen C. Strom, Vsevolod E. Kostrubsky, James Burliegh, Janean Hanson, Jasminder Sahi, Ellen Urda, Kelly Rose, Philip Zocharski
Publikováno v:
Toxicological Sciences. 76:220-228
Inhibition of canalicular bile acid efflux by medications is associated with clinical liver toxicity, sometimes in the absence of major liver effects in experimental species. To predict the hepatotoxic potential of compounds in vitro and in vivo, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f28a4be05a1923e4f7819d91bb2beaa
https://doi.org/10.1093/toxsci/kfg217
https://doi.org/10.1093/toxsci/kfg217
Autor:
Juliana G. Szakacs, Peter R. Sinclair, Dane Wright, Vsevolod E. Kostrubsky, Steven A. Wrighton, J F Sinclair, Elizabeth H. Jeffery, William J. Bement, Sheryl G. Wood
Publikováno v:
Biochemical Pharmacology. 59:445-454
Ethanol and isopentanol are the predominant alcohols in alcoholic beverages. We have reported previously that pretreatment of rats with a liquid diet containing 6.3% ethanol plus 0.5% isopentanol for 7 days results in a synergistic increase in acetam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99b7abfd3016b463ae373ed13fa84ab7
https://doi.org/10.1016/s0006-2952(99)00349-4
https://doi.org/10.1016/s0006-2952(99)00349-4
Autor:
Peter R. Sinclair, Judith M. Jacobs, Steven A. Wrighton, Sheryl G. Wood, Calen E. Nichols, Doreen Marek, Jacqueline F. Sinclair, Angeline S. Andrew, Vsevolod E. Kostrubsky
Publikováno v:
Toxicology and Applied Pharmacology. 157:51-59
In earlier studies, sodium arsenite treatment was shown to decrease induction of enzymatic activities associated with hepatic CYPs in rats. Here we investigated the effect of sodium arsenite on induction of CYP2B, CYP1A, and CYP3A in primary cultures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2311647f9f54de081df758922bd2b9
https://doi.org/10.1006/taap.1999.8659
https://doi.org/10.1006/taap.1999.8659
Autor:
Lionel D. Lewis, Stephen C. Strom, Peter R. Sinclair, Steven A. Wrighton, Vsevolod E. Kostrubsky, Sheryl G. Wood, Erin G. Schuetz, John D. Schuetz, Jacqueline F. Sinclair
Publikováno v:
Archives of Biochemistry and Biophysics. 355:131-136
In primary cultures of human hepatocytes, paclitaxel (Taxol), at pharmacological concentrations, was demonstrated to induce immunoreactive cytochrome P4503A (CYP3A). The magnitude of the inductive response of the hepatocytes to Taxol varied in five s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220ba409f2c36718f5a1dc7ae8347771
https://doi.org/10.1006/abbi.1998.0730
https://doi.org/10.1006/abbi.1998.0730
Autor:
Sheryl G. Wood, Vsevolod E. Kostrubsky, Juliana G. Szakacs, P R Sinclair, S Wrighton, Elizabeth H. Jeffery, J F Sinclair
Publikováno v:
Biochemical Pharmacology. 55:1557-1565
This commentary focuses on the roles of CYP3A and CYP2E in alcohol-mediated increases in acetaminophen hepatotoxicity. CYP2E has been considered to be the main form of P450 responsible for such toxicity in animals and humans. However, CYP3A, which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6f5a32846a766e8877c05b581180837
https://doi.org/10.1016/s0006-2952(97)00656-4
https://doi.org/10.1016/s0006-2952(97)00656-4
Autor:
Elizabeth H. Jeffery, William J. Bement, Jacqueline F. Sinclair, Peter R. Sinclair, Vsevolod E. Kostrubsky, Sheryl G. Wood, Steven A. Wrighton, Juliana G. Szakacs
Publikováno v:
Toxicology and Applied Pharmacology. 143:315-323
CYP2E is considered the only form of cytochrome P450 responsible for ethanol-mediated increases in acetaminophen hepatotoxicity. However, in experimental systems used for investigating ethanol-mediated increases in acetaminophen hepatotoxicity, anima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72315344f12b2eed0a4262fb638764a6
https://doi.org/10.1006/taap.1996.8081
https://doi.org/10.1006/taap.1996.8081
Autor:
Steven A. Wrighton, Lionel D. Lewis, Jacqueline F. Sinclair, Vsevolod E. Kostrubsky, Sheryl G. Wood, Peter R. Sinclair
Publikováno v:
Toxicology and Applied Pharmacology. 142:79-86
The purpose of this study was to determine if Taxol induced CYP3A in primary cultures of rat hepatocytes and, if so, whether induction of CYP3A would increase acetaminophen toxicity. Taxol caused a concentration-dependent increase in the amount of im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb813088e5d11f3f98a7d0294331335
https://doi.org/10.1006/taap.1996.8023
https://doi.org/10.1006/taap.1996.8023