A read-across case study on chronic toxicity of branched carboxylic acids (1): Integration of mechanistic evidence from new approach methodologies (NAMs) to explore a common mode of action

Autor: Escher SE, Aguayo-Orozco A, Benfenati E, Bitsch A, Braunbeck T, Brotzmann K, Bois F, van der Burg B, Castel J, Exner T, Gadaleta D, Gardner I, Goldmann D, Hatley O, Golbamaki N, Graepel R, Jennings P, Limonciel A, Long A, Maclennan R, Mombelli E, Norinder U, Jain S, Capinha LS, Taboureau OT, Tolosa L, Vrijenhoek NG, van Vugt-Lussenburg BMA, Walker P, van de Water B, Wehr M, White A, Zdrazil B, Fisher C

Publikováno v: TOXICOLOGY IN VITRO
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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This read-across case study characterises thirteen, structurally similar carboxylic acids demonstrating the application of in vitro and in silico human-based new approach methods, to determine biological similarity. Based on data from in vivo animal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::8c5dd590086ef2c34763ed7dac442b62
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=15208

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation.

Autor: van der Stel W; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Leiden, The Netherlands., Yang H; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Leiden, The Netherlands., Vrijenhoek NG; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Leiden, The Netherlands., Schimming JP; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Leiden, The Netherlands., Callegaro G; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Leiden, The Netherlands., Carta G; Division Molecular and Computational Toxicology, Vrije University Amsterdam, Amsterdam, The Netherlands., Darici S; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Leiden, The Netherlands., Delp J; Chair for In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Konstanz, Germany., Forsby A; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden., White A; Unilever, Bedfordshire, UK., le Dévédec S; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Leiden, The Netherlands., Leist M; Chair for In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Konstanz, Germany., Jennings P; Division Molecular and Computational Toxicology, Vrije University Amsterdam, Amsterdam, The Netherlands., Beltman JB; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Leiden, The Netherlands., van de Water B; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Leiden, The Netherlands. b.water@lacdr.leidenuniv.nl., Danen EHJ; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Leiden, The Netherlands. e.danen@lacdr.leidenuniv.nl.

Publikováno v: Archives of toxicology [Arch Toxicol] 2022 Jan; Vol. 96 (1), pp. 259-285. Date of Electronic Publication: 2021 Oct 13.

The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods.

Autor: Krebs A; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany.; Konstanz Research School Chemical Biology, University of Konstanz, 78457, Konstanz, Germany., van Vugt-Lussenburg BMA; BioDetection Systems BV, Science Park 406, 1098 XH, Amsterdam, The Netherlands., Waldmann T; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany.; trenzyme GmbH, Byk-Gulden-Str. 2, 78467, Konstanz, Germany., Albrecht W; Leibniz-Institut für Arbeitsforschung an der TU Dortmund, Leibniz Research Center for Working Environment and Human Factors (IfADo), Ardeystraße 67, 44139, Dortmund, Germany., Boei J; Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands., Ter Braak B; Division of Drug Discovery and Safety, Leiden Academic Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands., Brajnik M; Edelweiss Connect GmbH, Technology Park Basel, Hochbergerstrasse 60C, 4057, Basel, Switzerland., Braunbeck T; Aquatic Ecology and Toxicology Group, Center for Organismal Studies, University of Heidelberg, Im Neuenheimer Feld 504, 69120, Heidelberg, Germany., Brecklinghaus T; Leibniz-Institut für Arbeitsforschung an der TU Dortmund, Leibniz Research Center for Working Environment and Human Factors (IfADo), Ardeystraße 67, 44139, Dortmund, Germany., Busquet F; CAAT Europe, University of Konstanz, Steinbeis SU-1866, 78457, Konstanz, Germany., Dinnyes A; BioTalentum Ltd., Aulich Lajos str. 26, Gödöllő, 2100, Hungary., Dokler J; Edelweiss Connect GmbH, Technology Park Basel, Hochbergerstrasse 60C, 4057, Basel, Switzerland., Dolde X; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany., Exner TE; Edelweiss Connect GmbH, Technology Park Basel, Hochbergerstrasse 60C, 4057, Basel, Switzerland., Fisher C; Simcyp Division, Certara UK Limited, Level 2-Acero, 1 Concourse Way, Sheffield, S1 2BJ, UK., Fluri D; InSphero AG, Wagistrasse 27, 8952, Schlieren, Switzerland., Forsby A; Unit of Toxicology Sciences, Swedish Toxicology Sciences Research Center (Swetox), Karolinska Institutet, Forskargatan 20, 151 36, Södertälje, Sweden.; Department of Biochemistry and Biophysics, Stockholm University, 10691, Stockholm, Sweden., Hengstler JG; Leibniz-Institut für Arbeitsforschung an der TU Dortmund, Leibniz Research Center for Working Environment and Human Factors (IfADo), Ardeystraße 67, 44139, Dortmund, Germany., Holzer AK; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany., Janstova Z; BioTalentum Ltd., Aulich Lajos str. 26, Gödöllő, 2100, Hungary., Jennings P; Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands., Kisitu J; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany.; Konstanz Research School Chemical Biology, University of Konstanz, 78457, Konstanz, Germany., Kobolak J; BioTalentum Ltd., Aulich Lajos str. 26, Gödöllő, 2100, Hungary., Kumar M; Department of Development and Regeneration, Stem Cell Biology and Embryology, Stem Cell Institute Leuven, KU Leuven, O&N IV Herestraat 49, 3000, Leuven, Belgium., Limonciel A; Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands., Lundqvist J; Unit of Toxicology Sciences, Swedish Toxicology Sciences Research Center (Swetox), Karolinska Institutet, Forskargatan 20, 151 36, Södertälje, Sweden.; Department of Biochemistry and Biophysics, Stockholm University, 10691, Stockholm, Sweden., Mihalik B; BioTalentum Ltd., Aulich Lajos str. 26, Gödöllő, 2100, Hungary., Moritz W; InSphero AG, Wagistrasse 27, 8952, Schlieren, Switzerland., Pallocca G; CAAT Europe, University of Konstanz, Steinbeis SU-1866, 78457, Konstanz, Germany., Ulloa APC; Unit of Toxicology Sciences, Swedish Toxicology Sciences Research Center (Swetox), Karolinska Institutet, Forskargatan 20, 151 36, Södertälje, Sweden., Pastor M; Department of Experimental and Health Sciences, Research Programme on Biomedical Informatics (GRIB), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Universitat Pompeu Fabra, 08003, Barcelona, Spain., Rovida C; CAAT Europe, University of Konstanz, Steinbeis SU-1866, 78457, Konstanz, Germany., Sarkans U; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK., Schimming JP; Leiden Academic Center for Drug Research, LACDR/Toxicology, Leiden University, PO Box 9500, 2300 RA, Leiden, The Netherlands., Schmidt BZ; Switch Laboratory, Department of Cellular and Molecular Medicine, VIB-KU Leuven Center for Brain and Disease Research, KU Leuven, Herestraat 49, 3000, Leuven, Belgium., Stöber R; Leibniz-Institut für Arbeitsforschung an der TU Dortmund, Leibniz Research Center for Working Environment and Human Factors (IfADo), Ardeystraße 67, 44139, Dortmund, Germany., Strassfeld T; InSphero AG, Wagistrasse 27, 8952, Schlieren, Switzerland., van de Water B; Leiden Academic Center for Drug Research, LACDR/Toxicology, Leiden University, PO Box 9500, 2300 RA, Leiden, The Netherlands., Wilmes A; Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands., van der Burg B; BioDetection Systems BV, Science Park 406, 1098 XH, Amsterdam, The Netherlands., Verfaillie CM; Department of Development and Regeneration, Stem Cell Biology and Embryology, Stem Cell Institute Leuven, KU Leuven, O&N IV Herestraat 49, 3000, Leuven, Belgium., von Hellfeld R; Aquatic Ecology and Toxicology Group, Center for Organismal Studies, University of Heidelberg, Im Neuenheimer Feld 504, 69120, Heidelberg, Germany., Vrieling H; Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands., Vrijenhoek NG; Leiden Academic Center for Drug Research, LACDR/Toxicology, Leiden University, PO Box 9500, 2300 RA, Leiden, The Netherlands., Leist M; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany. marcel.leist@uni-konstanz.de.; CAAT Europe, University of Konstanz, Steinbeis SU-1866, 78457, Konstanz, Germany. marcel.leist@uni-konstanz.de.

Publikováno v: Archives of toxicology [Arch Toxicol] 2020 Jul; Vol. 94 (7), pp. 2435-2461. Date of Electronic Publication: 2020 Jul 06.