Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics.

Autor: Friess MC; Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland., Kritikos I; Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland., Schineis P; Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland., Medina-Sanchez JD; Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland., Gkountidi AO; Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland., Vallone A; Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland., Sigmund EC; Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland., Schwitter C; Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland., Vranova M; Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland., Matti C; Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Kreuzlingen, Switzerland., Arasa J; Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland., Saygili Demir C; Department of Oncology, University of Lausanne and Ludwig Institute for Cancer Research, Lausanne, Epalinges, Switzerland., Bovay E; Department of Oncology, University of Lausanne and Ludwig Institute for Cancer Research, Lausanne, Epalinges, Switzerland., Proulx ST; Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland; Theodor Kocher Institute, University of Bern, Bern, Switzerland., Tomura M; Osaka Ohtani University, Osaka, Japan., Rot A; Centre for Microvascular Research, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK; Centre for Inflammation and Therapeutic Innovation, Queen Mary University London, London, UK; Institute for Cardiovascular Prevention, Ludwig-Maximilians University, Munich, Germany., Legler DF; Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Kreuzlingen, Switzerland; Theodor Kocher Institute, University of Bern, Bern, Switzerland; Faculty of Biology, University of Konstanz, Konstanz, Germany., Petrova TV; Department of Oncology, University of Lausanne and Ludwig Institute for Cancer Research, Lausanne, Epalinges, Switzerland., Halin C; Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland. Electronic address: cornelia.halin@pharma.ethz.ch.

Publikováno v: Cell reports [Cell Rep] 2022 Feb 01; Vol. 38 (5), pp. 110334.

Identification of critical residues at the C-terminal tip of ACKR4 regulating chemokine internalization and βarrestin involvement.

Autor: Gerken, Oliver J.^1,2 (AUTHOR), Catone, Nicola¹ (AUTHOR), Legler, Daniel F.^1,3,4 (AUTHOR) daniel.legler@bitg.ch

Publikováno v: Cell Communication & Signaling. 12/2/2024, Vol. 22 Issue 1, p1-12. 12p.

Selective, Temporary Postoperative Inhibition of Lymphangiogenesis by Integrin α5β1 Blockade Improves Allograft Survival in a Murine Model of High-Risk Corneal Transplantation.

Autor: Dietrich-Ntoukas, Tina^1,2 (AUTHOR) jasmine.onderka@uk-erlangen.de, Bock, Felix³ (AUTHOR) felix.bock@uk-koeln.de, Onderka, Jasmine² (AUTHOR), Hos, Deniz³ (AUTHOR) deniz.hos@uk-koeln.de, Bachmann, Bjoern O.³ (AUTHOR) bjoern.bachmann@uk-koeln.de, Zahn, Grit⁴ (AUTHOR), Cursiefen, Claus³ (AUTHOR) claus.cursiefen@uk-koeln.de

Publikováno v: Journal of Clinical Medicine. Aug2024, Vol. 13 Issue 15, p4418. 11p.

ALCAM Mediates DC Migration Through Afferent Lymphatics and Promotes Allospecific Immune Reactions.

Autor: Willrodt AH; Institute of Pharmaceutical Sciences, ETH Zürich, Zurich, Switzerland., Salabarria AC; Department of Ophthalmology, University of Cologne, Cologne, Germany., Schineis P; Institute of Pharmaceutical Sciences, ETH Zürich, Zurich, Switzerland., Ignatova D; Department of Dermatology, University Hospital of Zürich, University of Zurich, Zurich, Switzerland., Hunter MC; Institute of Pharmaceutical Sciences, ETH Zürich, Zurich, Switzerland., Vranova M; Institute of Pharmaceutical Sciences, ETH Zürich, Zurich, Switzerland., Golding-Ochsenbein AM; Institute of Pharmaceutical Sciences, ETH Zürich, Zurich, Switzerland., Sigmund E; Institute of Pharmaceutical Sciences, ETH Zürich, Zurich, Switzerland., Romagna A; Institute of Pharmaceutical Sciences, ETH Zürich, Zurich, Switzerland., Strassberger V; Institute of Pharmaceutical Sciences, ETH Zürich, Zurich, Switzerland., Fabbi M; IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Ferrini S; IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Cursiefen C; Department of Ophthalmology, University of Cologne, Cologne, Germany.; Center Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Neri D; Institute of Pharmaceutical Sciences, ETH Zürich, Zurich, Switzerland., Guenova E; Department of Dermatology, University Hospital of Zürich, University of Zurich, Zurich, Switzerland., Bock F; Department of Ophthalmology, University of Cologne, Cologne, Germany.; Center Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Halin C; Institute of Pharmaceutical Sciences, ETH Zürich, Zurich, Switzerland.

Publikováno v: Frontiers in immunology [Front Immunol] 2019 Apr 12; Vol. 10, pp. 759. Date of Electronic Publication: 2019 Apr 12 (Print Publication: 2019).

Stromal Expression of Activated Leukocyte Cell Adhesion Molecule Promotes Lung Tumor Growth and Metastasis.

Autor: Willrodt AH; Institute of Pharmaceutical Sciences, ETH Zurich (Swiss Federal Institute of Technology), Zurich, Switzerland., Beffinger M; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Vranova M; Institute of Pharmaceutical Sciences, ETH Zurich (Swiss Federal Institute of Technology), Zurich, Switzerland., Protsyuk D; Institute of Physiology, University of Zurich, Zurich, Switzerland., Schuler K; Institute of Pharmaceutical Sciences, ETH Zurich (Swiss Federal Institute of Technology), Zurich, Switzerland., Jadhav M; Institute of Pharmaceutical Sciences, ETH Zurich (Swiss Federal Institute of Technology), Zurich, Switzerland., Heikenwalder M; Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany., van den Broek M; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Borsig L; Institute of Physiology, University of Zurich, Zurich, Switzerland., Halin C; Institute of Pharmaceutical Sciences, ETH Zurich (Swiss Federal Institute of Technology), Zurich, Switzerland. Electronic address: cornelia.halin@pharma.ethz.ch.

Publikováno v: The American journal of pathology [Am J Pathol] 2017 Nov; Vol. 187 (11), pp. 2558-2569. Date of Electronic Publication: 2017 Aug 17.