[Mitochondria-targeted antioxidant SkQR1 selectively protects MDR-negative cells against ionizing radiation]

Autor: Elena Fetisova, Mm, Antoshina, Vd, Cherepanynets, Ds, Izumov, Ii, Kireev, Ri, Kireev, Kg, Lyamzaev, Ni, Riabchenko, Bv, Chernyak, Vp, Skulachev

Publikováno v: Europe PubMed Central

Radioprotection appeared to be an important problem of today due to atom energetic development and utilization of radiation material in the industry, science and medicine. It has been shown that mitochondrial targeted antioxidant SkQR1 could attenuat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d0ae1d63bc69c16d9f81c04fdaeca02e
https://pubmed.ncbi.nlm.nih.gov/25929130

[Preparation and characterization of mouse embryonic fibroblasts with K72W mutation in somatic cytochrome C gene]

Autor: Ilgiz Mufazalov, Dn, Pen Kov, Bv, Cherniak, Pletiushkina OIu, Vysokikh MIu, Mp, Kirpichnikov, Da, Dolgikh, Aa, Kruglov, Dv, Kuprash, Vp, Skulachev, Sa, Nedospasov

Publikováno v: Europe PubMed Central

Mouse embryonic fibroblasts (MEF) with point mutation in somatic cytochrome C gene were generated and characterized. It was shown that substitution of lysine for tryptophan in position 72 (K72W) decreased the proapoptotic functions of cytochrome C in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f7e83e6b3e52544f01e5d1bec36396b0
http://europepmc.org/abstract/med/19807028

Age-associated murine cardiac lesions are attenuated by the mitochondria-targeted antioxidant SkQ1

Autor: Vn, Manskikh, Os, Gancharova, Ai, Nikiforova, Ms, Krasilshchikova, Ig, Shabalina, Mv, Egorov, Em, Karger, Ge, Milanovsky, Ii, Galkin, Vp, Skulachev, Roman Zinovkin

Publikováno v: Europe PubMed Central

Age-related changes in mammalian hearts often result in cardiac hypertrophy and fibrosis that are preceded by inflammatory infiltration. In this paper, we show that lifelong treatment of BALB/c and C57BL/6 mice with the mitochondria-targeted antioxid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::36bc63c8316c1b3a0c97173bd369b5eb
http://europepmc.org/abstract/med/25323729

Age-Dependent Changes in the Production of Mitochondrial Reactive Oxygen Species in Human Skeletal Muscle.

Autor: Vyssokikh MY; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia. mikhail.vyssokikh@gmail.com.; National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V. I. Kulakov, Moscow, 117997, Russia.; Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia., Vigovskiy MA; Medical Research and Education Center, Lomonosov Moscow State University, Moscow, 119192, Russia., Philippov VV; Medical Research and Education Center, Lomonosov Moscow State University, Moscow, 119192, Russia., Boroday YR; Medical Research and Education Center, Lomonosov Moscow State University, Moscow, 119192, Russia., Marey MV; National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V. I. Kulakov, Moscow, 117997, Russia., Grigorieva OA; Medical Research and Education Center, Lomonosov Moscow State University, Moscow, 119192, Russia., Vepkhvadze TF; Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia., Kurochkina NS; Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia., Manukhova LA; National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V. I. Kulakov, Moscow, 117997, Russia., Efimenko AY; Medical Research and Education Center, Lomonosov Moscow State University, Moscow, 119192, Russia., Popov DV; Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia., Skulachev VP; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia.

Publikováno v: Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2024 Feb; Vol. 89 (2), pp. 299-312.

Mitochondrion-targeted antioxidant SkQ1 prevents rapid animal death caused by highly diverse shocks.

Autor: Skulachev VP; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia, 119991. skulach@belozersky.msu.ru., Vyssokikh MY; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia, 119991. mikhail.vyssokikh@gmail.com., Chernyak BV; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia, 119991. bchernyak1@gmail.com.; Institute of Mitoengineering, Lomonosov Moscow State University, Moscow, Russia, 119991. bchernyak1@gmail.com., Averina OA; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia, 119991.; Institute of Mitoengineering, Lomonosov Moscow State University, Moscow, Russia, 119991., Andreev-Andrievskiy AA; Institute of Mitoengineering, Lomonosov Moscow State University, Moscow, Russia, 119991.; Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia, 119991., Zinovkin RA; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia, 119991.; Institute of Mitoengineering, Lomonosov Moscow State University, Moscow, Russia, 119991., Lyamzaev KG; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia, 119991.; Institute of Mitoengineering, Lomonosov Moscow State University, Moscow, Russia, 119991., Marey MV; Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia, 117198., Egorov MV; Institute of Mitoengineering, Lomonosov Moscow State University, Moscow, Russia, 119991., Frolova OJ; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia, 119991.; Institute of Mitoengineering, Lomonosov Moscow State University, Moscow, Russia, 119991., Zorov DB; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia, 119991., Skulachev MV; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia, 119991., Sadovnichii VA; Faculty of Mechanics and Mathematics, Lomonosov Moscow State University, Moscow, Russia, 119991.

Publikováno v: Scientific reports [Sci Rep] 2023 Mar 15; Vol. 13 (1), pp. 4326. Date of Electronic Publication: 2023 Mar 15.