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Akademický článek

Electrophoretic mobility of latex particles: effect of particle size and surface structure

Autor: Vorwerg, L ^*, Antonietti, M, Tauer, K

Publikováno v: In Colloids and Surfaces A: Physicochemical and Engineering Aspects 1999 150(1):129-135

Fast QC of Intact Monoclonal Antibodies Using MALDI-Top-Down Sequencing

Autor: Paape, R., Vorwerg, L., Suckau, D., Resemann, A.

Antibodies are playing an important role in drug development in the last years. The function of therapeutic monoclonal antibodies (mAbs) is directly depending on their structure including terminal modifications like C-terminal lysine excision and N-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::4d7d9b336f9feabb6131dbdc2de90b05
https://europepmc.org/articles/PMC3186624/

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Top-Down Mass Spectrometric Sequence Analysis of 116 kDa E. coli β-galactosidase

Autor: Paape, R., Vorwerg, L., Suckau, D., Resemann, A.

Most Top-Down mass spectrometric studies performed so far focused on proteins in the 20-50 kDa range, even monoclonal antibodies are comprised of protein chains smaller than 50 kDa. However, the interest in large protein top-down analysis increases a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::dc5cec791ed6c67e7e3e0252710b97e4
https://europepmc.org/articles/PMC3186526/

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P41-M Automated LC-MALDI Analysis of Glycopeptides from Glycoprotein Digests Using DHB as Matrix

Autor: Resemann, A., Asperger, A., Sparbier, K., Seemann, K., Eichhorn, T., Hunzinger, C., Stein, G., Vorwerg, L., Suckau, D.

2,5-Dihydroxybenzoic acid (DHB) is the matrix of choice for carbohydrate and glycopeptide analysis, but due to the inhomogeneous surface morphology of samples prepared with DHB, it is typically incompatible with automated measurements.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::721a2e3b18eff17c1b159da52aeffce0
https://europepmc.org/articles/PMC2291954/

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P203-M A Software Platform for the Validation of Quantitative Proteomics Data

Autor: Jabs, W., Hahner, S., Schweiger-Hufnagel, U., Behrens, M., Lubeck, M., Asperger, A., Kaminski, H., Vorwerg, L., Bäßmann, C., Suckau, D.

Methods based on isotope labeling and LC-MS/MS analysis are becoming a standard approach for the simultaneous identification and quantification of proteins on the proteomic scale, as they provide high accuracy, precision, sensitivity, speed, and comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::0b5f5b9139f4725acb9454e99cdecf88
https://europepmc.org/articles/PMC2292000/

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P145-S Interactive and Automated Top-Down Analysis of Sequencing Data of Intact Proteins

Autor: Suckau, D., Vorwerg, L., Resemann, A., Witt, M., Easterling, M.

In a Top-Down workflow (ECD, ETD, ISD) the whole protein molecule is subjected to fragmentation and proteins are not digested (as in the Bottom-Up approach). This allows the detection of signal peptides, modifications, sequence variations and mutatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::bebf5eda8b2ee2ca4da5ce6361efd3d7
https://europepmc.org/articles/PMC2291934/

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P183-T Analysis of Glycoproteins in Human Serum by Means of Glyco-Specific Magnetic Bead Separation and LC-MALDI with Automated Glycopeptide Detection

Autor: Sparbier, K., Asperger, A., Resemann, A., Kessler, I., Koch, S., Wenzel, T., Shi, G., Stein, G., Vorwerg, L., Suckau, D., Kostrzewa, M.

Comprehensive proteomic analyses require efficient and selective pre-fractionation to facilitate analysis of post-translationally modified peptides and proteins and automated analysis procedures for the detection, identification, and structural chara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::6f534aac4bbd85a8ea1c5819ac658635
https://europepmc.org/articles/PMC2291947/

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Akademický článek

Mass Spectrometry Strategies for O -Glycoproteomics.

Autor: Helms, Amanda¹ (AUTHOR) amanda.helms@utexas.edu, Brodbelt, Jennifer S.¹ (AUTHOR) jbrodbelt@cm.utexas.edu

Publikováno v: Cells (2073-4409). Mar2024, Vol. 13 Issue 5, p394. 27p.

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Akademický článek

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Akademický článek

Full validation of therapeutic antibody sequences by middle-up mass measurements and middle-down protein sequencing.

Autor: Resemann A; a Bruker Daltonics GmbH , Fahrenheitstr. 4, Bremen , Germany., Jabs W; a Bruker Daltonics GmbH , Fahrenheitstr. 4, Bremen , Germany., Wiechmann A; a Bruker Daltonics GmbH , Fahrenheitstr. 4, Bremen , Germany., Wagner E; b Centre d'Immunologie Pierre , St Julien-en-Genevois, France., Colas O; b Centre d'Immunologie Pierre , St Julien-en-Genevois, France., Evers W; a Bruker Daltonics GmbH , Fahrenheitstr. 4, Bremen , Germany., Belau E; a Bruker Daltonics GmbH , Fahrenheitstr. 4, Bremen , Germany., Vorwerg L; a Bruker Daltonics GmbH , Fahrenheitstr. 4, Bremen , Germany., Evans C; c Bruker Daltonics Ltd , Coventry , UK., Beck A; b Centre d'Immunologie Pierre , St Julien-en-Genevois, France., Suckau D; a Bruker Daltonics GmbH , Fahrenheitstr. 4, Bremen , Germany.

Publikováno v: MAbs [MAbs] 2016; Vol. 8 (2), pp. 318-30. Date of Electronic Publication: 2016 Jan 13.

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