Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Vorwerg, L"'
Publikováno v:
In Colloids and Surfaces A: Physicochemical and Engineering Aspects 1999 150(1):129-135
Antibodies are playing an important role in drug development in the last years. The function of therapeutic monoclonal antibodies (mAbs) is directly depending on their structure including terminal modifications like C-terminal lysine excision and N-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmc_________::4d7d9b336f9feabb6131dbdc2de90b05
https://europepmc.org/articles/PMC3186624/
https://europepmc.org/articles/PMC3186624/
Most Top-Down mass spectrometric studies performed so far focused on proteins in the 20-50 kDa range, even monoclonal antibodies are comprised of protein chains smaller than 50 kDa. However, the interest in large protein top-down analysis increases a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmc_________::dc5cec791ed6c67e7e3e0252710b97e4
https://europepmc.org/articles/PMC3186526/
https://europepmc.org/articles/PMC3186526/
Autor:
Resemann, A., Asperger, A., Sparbier, K., Seemann, K., Eichhorn, T., Hunzinger, C., Stein, G., Vorwerg, L., Suckau, D.
2,5-Dihydroxybenzoic acid (DHB) is the matrix of choice for carbohydrate and glycopeptide analysis, but due to the inhomogeneous surface morphology of samples prepared with DHB, it is typically incompatible with automated measurements.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmc_________::721a2e3b18eff17c1b159da52aeffce0
https://europepmc.org/articles/PMC2291954/
https://europepmc.org/articles/PMC2291954/
Autor:
Jabs, W., Hahner, S., Schweiger-Hufnagel, U., Behrens, M., Lubeck, M., Asperger, A., Kaminski, H., Vorwerg, L., Bäßmann, C., Suckau, D.
Methods based on isotope labeling and LC-MS/MS analysis are becoming a standard approach for the simultaneous identification and quantification of proteins on the proteomic scale, as they provide high accuracy, precision, sensitivity, speed, and comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmc_________::0b5f5b9139f4725acb9454e99cdecf88
https://europepmc.org/articles/PMC2292000/
https://europepmc.org/articles/PMC2292000/
In a Top-Down workflow (ECD, ETD, ISD) the whole protein molecule is subjected to fragmentation and proteins are not digested (as in the Bottom-Up approach). This allows the detection of signal peptides, modifications, sequence variations and mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmc_________::bebf5eda8b2ee2ca4da5ce6361efd3d7
https://europepmc.org/articles/PMC2291934/
https://europepmc.org/articles/PMC2291934/
Autor:
Sparbier, K., Asperger, A., Resemann, A., Kessler, I., Koch, S., Wenzel, T., Shi, G., Stein, G., Vorwerg, L., Suckau, D., Kostrzewa, M.
Comprehensive proteomic analyses require efficient and selective pre-fractionation to facilitate analysis of post-translationally modified peptides and proteins and automated analysis procedures for the detection, identification, and structural chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmc_________::6f534aac4bbd85a8ea1c5819ac658635
https://europepmc.org/articles/PMC2291947/
https://europepmc.org/articles/PMC2291947/
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