Novel pentacyclic derivatives and benzylidenes of the progesterone series cause anti-estrogenic and antiproliferative effects and induce apoptosis in breast cancer cells.

Autor: Scherbakov AM; Department of Experimental Tumor Biology, Blokhin N.N. National Medical Research Center of Oncology, Kashirskoye shosse 24, 115522, Moscow, Russia. a.sherbakov@ronc.ru., Vorontsova SK; N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, 119991, Moscow, Russia., Khamidullina AI; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Vavilov Street 34/5, 119334, Moscow, Russian Federation., Mrdjanovic J; Oncology Institute of Vojvodina, Faculty of Medicine, University of Novi Sad, Put Dr Goldmana 4, 21204, Sremska Kamenica, Serbia., Andreeva OE; Department of Experimental Tumor Biology, Blokhin N.N. National Medical Research Center of Oncology, Kashirskoye shosse 24, 115522, Moscow, Russia., Bogdanov FB; Department of Experimental Tumor Biology, Blokhin N.N. National Medical Research Center of Oncology, Kashirskoye shosse 24, 115522, Moscow, Russia.; Faculty of Medicine, Moscow State University, Lomonosovsky prospect 27 bldg. 1, 119991, Moscow, Russia., Salnikova DI; Department of Experimental Tumor Biology, Blokhin N.N. National Medical Research Center of Oncology, Kashirskoye shosse 24, 115522, Moscow, Russia., Jurisic V; Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000, Kragujevac, Serbia., Zavarzin IV; N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, 119991, Moscow, Russia., Shirinian VZ; N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, 119991, Moscow, Russia.

Publikováno v: Investigational new drugs [Invest New Drugs] 2023 Feb; Vol. 41 (1), pp. 142-152. Date of Electronic Publication: 2023 Jan 25.

Synthesis and evaluation of the antiproliferative activity of benzylidenes of 16-dehydroprogesterone series.

Autor: Scherbakov AM; N.N. Blokhin National Medical Research Center of Oncology, Kashirskoye shosse 24, 115478 Moscow, Russia. Electronic address: alex.scherbakov@gmail.com., Zavarzin IV; N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prosp. 47, 119991 Moscow, Russia. Electronic address: igorzavarzin@yandex.ru., Vorontsova SK; N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prosp. 47, 119991 Moscow, Russia. Electronic address: vorontsova_s@mail.ru., Hajra A; Department of Chemistry, Visva-Bharati (A Central University), Santiniketan, India. Electronic address: alakananda.hajra@visva-bharati.ac.in., Andreeva OE; N.N. Blokhin National Medical Research Center of Oncology, Kashirskoye shosse 24, 115478 Moscow, Russia. Electronic address: tilberta@gmail.com., Yadykov AV; N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prosp. 47, 119991 Moscow, Russia. Electronic address: antonyadykov@gmail.com., Levina IS; N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prosp. 47, 119991 Moscow, Russia. Electronic address: Li@ioc.ac.ru., Volkova YA; N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prosp. 47, 119991 Moscow, Russia. Electronic address: yavolkova@gmail.com., Shirinian VZ; N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prosp. 47, 119991 Moscow, Russia. Electronic address: svbegunt@mail.ru.

Publikováno v: Steroids [Steroids] 2018 Oct; Vol. 138, pp. 91-101. Date of Electronic Publication: 2018 Jul 08.