Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms

Autor: Maculins, Timurs, Garcia-Pardo, Javier, Skenderovic, Anamarija, Gebel, Jakob, Putyrski, Mateusz, Vorobyov, Andrew, Busse, Philipp, Varga, Gabor, Kuzikov, Maria, Zaliani, Andrea, Rahighi, Simin, Schaeffer, Veronique, Parnham, Michael J., Sidhu, Sachdev S., Ernst, Andreas, Dötsch, Volker, Akutsu, Masato, Dikic, Ivan

Publikováno v: In Cell Chemical Biology 19 November 2020 27(11):1441-1451

Disrupting the LC3 Interaction Region (LIR) Binding of Selective Autophagy Receptors Sensitizes AML Cell Lines to Cytarabine

Autor: Putyrski, Mateusz, Vakhrusheva, Olesya, Bonn, Florian, Guntur, Suchithra, Vorobyov, Andrew, Brandts, Christian, Dikic, Ivan, Ernst, Andreas

Publikováno v: Frontiers in Cell and Developmental Biology

Short linear motifs (SLiMs) located in disordered regions of multidomain proteins are important for the organization of protein–protein interaction networks. By dynamic association with their binding partners, SLiMs enable assembly of multiprotein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f5dff93f634cd51e472eab6c2c014332
https://publica.fraunhofer.de/handle/publica/263438

Disrupting the LC3 Interaction Region (LIR) Binding of Selective Autophagy Receptors Sensitizes AML Cell Lines to Cytarabine.

Autor: Putyrski M; Institute of Biochemistry II, Medical Faculty, Goethe-University, Frankfurt, Germany.; Project Group Translational Medicine and Pharmacology, Fraunhofer Institute for Molecular Biology and Applied Ecology, Frankfurt, Germany., Vakhrusheva O; Department of Medicine, Hematology/Oncology, Goethe-University, Frankfurt, Germany., Bonn F; Institute of Biochemistry II, Medical Faculty, Goethe-University, Frankfurt, Germany., Guntur S; Institute of Biochemistry II, Medical Faculty, Goethe-University, Frankfurt, Germany., Vorobyov A; Project Group Translational Medicine and Pharmacology, Fraunhofer Institute for Molecular Biology and Applied Ecology, Frankfurt, Germany., Brandts C; Department of Medicine, Hematology/Oncology, Goethe-University, Frankfurt, Germany.; German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany.; University Cancer Center Frankfurt, Goethe-University, Frankfurt, Germany., Dikic I; Institute of Biochemistry II, Medical Faculty, Goethe-University, Frankfurt, Germany.; Buchmann Institute for Molecular Life Sciences, Frankfurt, Germany., Ernst A; Institute of Biochemistry II, Medical Faculty, Goethe-University, Frankfurt, Germany.; Project Group Translational Medicine and Pharmacology, Fraunhofer Institute for Molecular Biology and Applied Ecology, Frankfurt, Germany.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2020 Mar 31; Vol. 8, pp. 208. Date of Electronic Publication: 2020 Mar 31 (Print Publication: 2020).