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Mapping disease regulatory circuits at cell-type resolution from single-cell multiomics data.

Autor: Chen X; Center for Computational Biology, Flatiron Institute, New York, NY, USA.; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA., Wang Y; Department of Computer Science, Princeton University, Princeton, NJ, USA., Cappuccio A; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cheng WS; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zamojski FR; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nair VD; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Miller CM; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rubenstein AB; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nudelman G; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tadych A; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA., Theesfeld CL; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA., Vornholt A; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., George MC; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ruffin F; Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Dagher M; Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Chawla DG; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA., Soares-Schanoski A; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Spurbeck RR; Battelle Memorial Institute, Columbus, OH, USA., Ndhlovu LC; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Sebra R; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kleinstein SH; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.; Department of Pathology and Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Letizia AG; Naval Medical Research Center, Silver Spring, MD, USA., Ramos I; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Fowler VG Jr; Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Woods CW; Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Zaslavsky E; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; These authors jointly supervised this work: Elena Zaslavsky, Olga G. Troyanskaya, Stuart C. Sealfon., Troyanskaya OG; Center for Computational Biology, Flatiron Institute, New York, NY, USA.; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.; Department of Computer Science, Princeton University, Princeton, NJ, USA.; These authors jointly supervised this work: Elena Zaslavsky, Olga G. Troyanskaya, Stuart C. Sealfon., Sealfon SC; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; These authors jointly supervised this work: Elena Zaslavsky, Olga G. Troyanskaya, Stuart C. Sealfon.

Publikováno v: Nature computational science [Nat Comput Sci] 2023 Jul; Vol. 3 (7), pp. 644-657. Date of Electronic Publication: 2023 Jul 25.