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Repeatability and reproducibility of the Forskolin-induced swelling (FIS) assay on intestinal organoids from people with Cystic Fibrosis.
Autor: Bierlaagh MC; Dept. of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Ramalho AS; KULeuven, Dept. of Development and Regeneration, Leuven, Belgium., Silva IAL; BioISI- Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, Lisboa, Portugal., Vonk AM; Dept. of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van den Bor RM; Dept. of Data Science and Biostatistics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., van Mourik P; Dept. of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Pott J; HUB Organoids B.V. (HUB), Utrecht, The Netherlands., Suen SWF; Dept. of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Boj SF; HUB Organoids B.V. (HUB), Utrecht, The Netherlands., Vries RGJ; HUB Organoids B.V. (HUB), Utrecht, The Netherlands., Lammertyn E; Cystic Fibrosis Europe & the Belgian Cystic Fibrosis Association, Brussels, Belgium., Vermeulen F; KULeuven, Dept. of Development and Regeneration, Leuven, Belgium., Amaral MD; BioISI- Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, Lisboa, Portugal., de Boeck K; KULeuven, Dept. of Development and Regeneration, Leuven, Belgium., van der Ent CK; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Beekman JM; Dept. of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Centre for Living Technologies, Alliance Eindhoven University of Technology, Wageningen University & Research, Utrecht University and University Medical Center Utrecht (EWUU), Utrecht, The Netherlands. Electronic address: J.Beekman@umcutrecht.nl.
Publikováno v: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2024 Jul; Vol. 23 (4), pp. 693-702. Date of Electronic Publication: 2024 May 14.
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Akademický článek
Centralized intestinal organoid generation is a feasible and safe approach for personalized medicine as demonstrated in the HIT-CF Europe Organoid Study.
Autor: Bierlaagh MC; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, UMCU, Utrecht, the Netherlands, member of ERN-LUNG; Regenerative Medicine Center (UMCU), Utrecht University, Utrecht, the Netherlands., van Mourik P; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, UMCU, Utrecht, the Netherlands, member of ERN-LUNG; Regenerative Medicine Center (UMCU), Utrecht University, Utrecht, the Netherlands., Vonk AM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, UMCU, Utrecht, the Netherlands, member of ERN-LUNG; Regenerative Medicine Center (UMCU), Utrecht University, Utrecht, the Netherlands., Pott J; HUB Organoids B.V. (HUB), Utrecht, the Netherlands., Muilwijk D; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, UMCU, Utrecht, the Netherlands, member of ERN-LUNG; Regenerative Medicine Center (UMCU), Utrecht University, Utrecht, the Netherlands., Berkers G; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, UMCU, Utrecht, the Netherlands, member of ERN-LUNG., Aalbers BL; Regenerative Medicine Center (UMCU), Utrecht University, Utrecht, the Netherlands., Vleggaar FP; Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, the Netherlands., Michel S; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, UMCU, Utrecht, the Netherlands, member of ERN-LUNG., Boj SF; HUB Organoids B.V. (HUB), Utrecht, the Netherlands., Vries RGJ; HUB Organoids B.V. (HUB), Utrecht, the Netherlands., Beekman JM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, UMCU, Utrecht, the Netherlands, member of ERN-LUNG; Regenerative Medicine Center (UMCU), Utrecht University, Utrecht, the Netherlands., van der Ent CK; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, UMCU, Utrecht, the Netherlands, member of ERN-LUNG. Electronic address: K.vanderEnt@umcutrecht.nl.
Publikováno v: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2024 Jul; Vol. 23 (4), pp. 703-706. Date of Electronic Publication: 2024 May 18.
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5
Akademický článek
Colonization of vancomycin-resistant Enterococcus faecium in human-derived colonic epithelium: unraveling the transcriptional dynamics of host-enterococcal interactions.
Autor: Stege PB; Department of Medical Microbiology, UMC Utrecht, Utrecht, 3584CX, The Netherlands., Beekman JM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, 3584CX, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, 3584CX, The Netherlands., Hendrickx APA; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), 3721MA, The Netherlands., van Eijk L; Department of Medical Microbiology, UMC Utrecht, Utrecht, 3584CX, The Netherlands., Rogers MRC; Department of Medical Microbiology, UMC Utrecht, Utrecht, 3584CX, The Netherlands., Suen SWF; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, 3584CX, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, 3584CX, The Netherlands., Vonk AM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, 3584CX, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, 3584CX, The Netherlands., Willems RJL; Department of Medical Microbiology, UMC Utrecht, Utrecht, 3584CX, The Netherlands., Paganelli FL; Department of Medical Microbiology, UMC Utrecht, Utrecht, 3584CX, The Netherlands.; Winclove Probiotics, Amsterdam, 1033JS, The Netherlands.
Publikováno v: FEMS microbes [FEMS Microbes] 2024 May 07; Vol. 5, pp. xtae014. Date of Electronic Publication: 2024 May 07 (Print Publication: 2024).
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6
Akademický článek
FDA-approved drug screening in patient-derived organoids demonstrates potential of drug repurposing for rare cystic fibrosis genotypes.
Autor: de Poel E; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, EA 3584, the Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, CT 3584, the Netherlands., Spelier S; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, EA 3584, the Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, CT 3584, the Netherlands., Hagemeijer MC; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, EA 3584, the Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, CT 3584, the Netherlands; Center for Lysosomal and Metabolic Diseases, Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, GD 3015, the Netherlands., van Mourik P; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, EA 3584, the Netherlands., Suen SWF; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, EA 3584, the Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, CT 3584, the Netherlands., Vonk AM; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, EA 3584, the Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, CT 3584, the Netherlands., Brunsveld JE; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, EA 3584, the Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, CT 3584, the Netherlands., Ithakisiou GN; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, EA 3584, the Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, CT 3584, the Netherlands., Kruisselbrink E; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, EA 3584, the Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, CT 3584, the Netherlands., Oppelaar H; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, EA 3584, the Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, CT 3584, the Netherlands., Berkers G; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, EA 3584, the Netherlands., de Winter de Groot KM; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, EA 3584, the Netherlands., Heida-Michel S; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, EA 3584, the Netherlands., Jans SR; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, EA 3584, the Netherlands., van Panhuis H; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, EA 3584, the Netherlands., Bakker M; Department of Pulmonology, Erasmus MC, University Medical Center, Rotterdam, GD 3015, the Netherlands., van der Meer R; Haga Teaching Hospital, The Hague, CH 2545, the Netherlands., Roukema J; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, XZ 6525, the Netherlands., Dompeling E; Maastricht University Medical Center, Maastricht, HX 6229, the Netherlands., Weersink EJM; Amsterdam University Medical Center, location AMC, Amsterdam, AZ 1105, the Netherlands., Koppelman GH; University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen, the Netherlands; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the Netherlands., Blaazer AR; Division of Medicinal Chemistry, Vrije Universiteit Amsterdam, Amsterdam, HZ 1081, the Netherlands., Muijlwijk-Koezen JE; Division of Medicinal Chemistry, Vrije Universiteit Amsterdam, Amsterdam, HZ 1081, the Netherlands., van der Ent CK; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, EA 3584, the Netherlands., Beekman JM; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, EA 3584, the Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, CT 3584, the Netherlands; Centre for Living Technologies, Alliance TU/e, WUR, UU, UMC Utrecht, Princetonlaan 6, Utrecht, CB 3584, the Netherlands. Electronic address: J.Beekman@umcutrecht.nl.
Publikováno v: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2023 May; Vol. 22 (3), pp. 548-559. Date of Electronic Publication: 2023 May 03.
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7
Akademický článek
Validating organoid-derived human intestinal monolayers for personalized therapy in cystic fibrosis.
Autor: Birimberg-Schwartz L; Department of Paediatrics, Division of Gastroenterology, Hepatology and Nutrition, University of Toronto, Toronto, Canada.; Translational Medicine, The Hospital for Sick Children, Toronto, Canada., Ip W; Translational Medicine, The Hospital for Sick Children, Toronto, Canada., Bartlett C; Translational Medicine, The Hospital for Sick Children, Toronto, Canada., Avolio J; Translational Medicine, The Hospital for Sick Children, Toronto, Canada., Vonk AM; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherland., Gunawardena T; Programme in Molecular Medicine, The Hospital for Sick Children, Toronto, Canada., Du K; Programme in Molecular Medicine, The Hospital for Sick Children, Toronto, Canada., Esmaeili M; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada., Beekman JM; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherland., Rommens J; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Strug L; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.; Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.; Department of Statistical Sciences and Computer Science, University of Toronto, Toronto, Canada.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Canada., Bear CE; Programme in Molecular Medicine, The Hospital for Sick Children, Toronto, Canada.; Department of Physiology, University of Toronto, Toronto, Canada.; Department of Biochemistry, University of Toronto, Toronto, Canada., Moraes TJ; Translational Medicine, The Hospital for Sick Children, Toronto, Canada.; Department of Paediatrics, Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Canada., Gonska T; Department of Paediatrics, Division of Gastroenterology, Hepatology and Nutrition, University of Toronto, Toronto, Canada Tanja.Gonska@sickkids.ca.; Translational Medicine, The Hospital for Sick Children, Toronto, Canada.
Publikováno v: Life science alliance [Life Sci Alliance] 2023 Apr 05; Vol. 6 (6). Date of Electronic Publication: 2023 Apr 05 (Print Publication: 2023).
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8
Akademický článek
High-throughput functional assay in cystic fibrosis patient-derived organoids allows drug repurposing.
Autor: Spelier S; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands.; These authors contributed equally to this work., de Poel E; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands.; These authors contributed equally to this work., Ithakisiou GN; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands., Suen SWF; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands., Hagemeijer MC; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Center for Lysosomal and Metabolic Diseases, Department of Clinical Genetics Erasmus University Medical Center, Rotterdam, The Netherlands., Muilwijk D; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands., Vonk AM; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands., Brunsveld JE; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands., Kruisselbrink E; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands., van der Ent CK; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands., Beekman JM; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands.
Publikováno v: ERJ open research [ERJ Open Res] 2023 Jan 30; Vol. 9 (1). Date of Electronic Publication: 2023 Jan 30 (Print Publication: 2023).
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9
Akademický článek
Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression.
Autor: Muilwijk D; Dept of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; These authors contributed equally to this work., de Poel E; Dept of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands.; These authors contributed equally to this work., van Mourik P; Dept of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands., Suen SWF; Dept of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands., Vonk AM; Dept of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands., Brunsveld JE; Dept of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands., Kruisselbrink E; Dept of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands., Oppelaar H; Dept of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands., Hagemeijer MC; Dept of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Center for Lysosomal and Metabolic Diseases, Dept of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands., Berkers G; Dept of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands., de Winter-de Groot KM; Dept of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands., Heida-Michel S; Dept of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands., Jans SR; Dept of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands., van Panhuis H; Dept of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands., van der Eerden MM; Dept of Pulmonology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands., van der Meer R; Haga Teaching Hospital, The Hague, The Netherlands., Roukema J; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Dompeling E; Maastricht University Medical Center, Maastricht, The Netherlands., Weersink EJM; Amsterdam University Medical Center, location AMC, Amsterdam, The Netherlands., Koppelman GH; University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen, The Netherlands.; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands., Vries R; Hubrecht Organoid Technology (HUB), Utrecht, The Netherlands., Zomer-van Ommen DD; Dutch Cystic Fibrosis Foundation (NCFS), Baarn, The Netherlands., Eijkemans MJC; Dept of Data Science and Biostatistics, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University, Utrecht, The Netherlands., van der Ent CK; Dept of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands.; C.K. van der Ent and J.M. Beekman contributed equally to this article as lead authors and supervised the work., Beekman JM; Dept of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, The Netherlands J.Beekman@umcutrecht.nl.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands.; Center for Living Technologies, University Medical Center, Utrecht, The Netherlands.; C.K. van der Ent and J.M. Beekman contributed equally to this article as lead authors and supervised the work.
Publikováno v: The European respiratory journal [Eur Respir J] 2022 Aug 18; Vol. 60 (2). Date of Electronic Publication: 2022 Aug 18 (Print Publication: 2022).
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10
Akademický článek
An open-source high-content analysis workflow for CFTR function measurements using the forskolin-induced swelling assay.
Autor: Hagemeijer MC; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Centre Utrecht, 3584 EA Utrecht, The Netherlands., Vonk AM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Centre Utrecht, 3584 EA Utrecht, The Netherlands., Awatade NT; BioISI - Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, 1749-016 Lisboa, Portugal., Silva IAL; BioISI - Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, 1749-016 Lisboa, Portugal., Tischer C; European Molecular Biology Laboratory (EMBL), Centre for Bioimage Analysis (CBA), 69117 Heidelberg, Germany., Hilsenstein V; European Molecular Biology Laboratory (EMBL), Advanced Light Microscopy Facility (ALMF), 69117 Heidelberg, Germany., Beekman JM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Centre Utrecht, 3584 EA Utrecht, The Netherlands., Amaral MD; BioISI - Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, 1749-016 Lisboa, Portugal., Botelho HM; BioISI - Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, 1749-016 Lisboa, Portugal.
Publikováno v: Bioinformatics (Oxford, England) [Bioinformatics] 2021 Apr 05; Vol. 36 (24), pp. 5686-5694.
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