Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Vongs, A."'
Autor:
Martin, William J., Howard, Andrew D., Nargund, Ravi P., Austin, Christopher P., Guan, Xiaoming, Drisko, Jennifer, Cashen, Doreen, Sebhat, Iyassu, Patchett, Arthur A., Figueroa, David J., DiLella, Anthony G., Connolly, Brett M., Weinberg, David H., Tan, Carina P., Palyha, Oksana C., Pong, Sheng-Shung, MacNeil, Tanya, Rosenblum, Charles, Vongs, Aurawan, Tang, Rui, Yu, Hong, Sailer, Andreas W., Fong, Tung Ming, Huang, Cathy, Tota, Michael R., Chang, Ray S., Stearns, Ralph, Tamvakopoulos, Constantin, Christ, George, Drazen, Deborah L., Spar, Brian D., Nelson, Randy J., MacIntyre, D. Euan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2002 Aug . 99(17), 11381-11386.
Externí odkaz:
https://www.jstor.org/stable/3059577
Autor:
Hua V Lin, Dunlu Chen, Zhu Shen, Lei Zhu, Xuesong Ouyang, Aurawan Vongs, Yanqing Kan, John M Levorse, Edward J Kowalik, Daphne M Szeto, Xiaorui Yao, Jianying Xiao, Shirley Chen, Jinqi Liu, Marga Garcia-Calvo, Myung K Shin, Shirly Pinto
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54480 (2013)
Diacylglycerol acyltransferase-1 (DGAT1) is a potential therapeutic target for treatment of obesity and related metabolic diseases. However, the degree of DGAT1 inhibition required for metabolic benefits is unclear. Here we show that partial DGAT1 de
Externí odkaz:
https://doaj.org/article/04d6fea951f2478297b3dfeed85ea767
Autor:
Ponn Vongs Vaddey
Publikováno v:
International Encyclopedia of Comparative Law Online
Externí odkaz:
https://doi.org/10.1163/2589-4021_IECO_COM_01KHM
Autor:
Doreen E. Cashen, Constantin Tamvakopoulos, Qianping Peng, William J. Martin, David H. Weinberg, Charles Rosenblum, Arthur A. Patchett, Tanya MacNeil, Patrick G. Pollard, Zhixiong Ye, Raman K. Bakshi, Ralph A. Stearns, Rubana N. Kalyani, Palucki Brenda, Joseph M. Metzger, Alison M. Strack, Lex H.T. Van der Ploeg, D. Euan MacIntyre, Iyassu K. Sebhat, Aurawan Vongs, Airu S. Chen, Ravi P. Nargund, Liangqin Guo, Matthew J. Wyvratt, Randy R. Miller, Rui Tang, Howard Y. Chen, Khaled J. Barakat
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3501-3505
A novel isoquinuclidine containing selective melanocortin subtype-4 receptor small molecule agonist, 3 (RY764), is reported. Its in vivo characterization revealed mechanism-based food intake reduction and erectile activity augmentation in rodents.
Autor:
George A. Doss, Lex H.T. Van der Ploeg, Qianping Peng, Ravi P. Nargund, Charles Rosenblum, Randall R. Miller, Aurawan Vongs, Palucki Brenda, Tanya MacNeil, Ralph A. Stearns, Min K. Park, David H. Weinberg, Rui Tang, Arthur A. Patchett, Constantin Tamvakopoulos
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1993-1996
We report the discovery and optimization of substituted 2-piperazinecarboxamides as potent and selective agonists of the melanocortin subtype-4 receptor. The 5- and 6-alkylated piperazine compounds exhibit low bioactivation potential as measured by c
Autor:
William J. Martin, D. Euan MacIntyre, Ravi P. Nargund, Rubana N. Kalyani, Rui Tang, George A. Doss, Min K. Park, Alison M. Strack, Erin McGowan, Joseph M. Metzger, Charles Rosenblum, Randall R. Miller, Palucki Brenda, Qianping Peng, Arthur A. Patchett, Ralph A. Stearns, Patrick G. Pollard, Lex H.T. Van der Ploeg, Iyassu K. Sebhat, Constantin Tamvakopoulos, Cherrie Shepherd, Aurawan Vongs, Tanya MacNeil, David H. Weinberg, Zhixiong Ye
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:171-175
We report the discovery and optimization of substituted 2-piperazinecarboxamides as potent and selective agonists of the melanocortin subtype-4 receptor. Further in vivo development of lead agonist, MB243, is disclosed.
Publikováno v:
Regulatory Peptides. 120:113-118
The melanocortin 4 receptor (MC4-R) is a Galpha s-coupled receptor known to increase cAMP production following agonist stimulation. We demonstrate that the mitogen-activated protein kinases p42 (ERK2) and p44 (ERK1) are also activated by MC4-R follow
Autor:
Mark T. Goulet, Lihu Yang, Aurawan Vongs, David H. Weinberg, Charles Rosenblum, Changyou Zhou, Feroze Ujjainwalla, Thomas F. Walsh, Matthew J. Wyvratt, Tanya MacNeil, Rubana N. Kalyani, Rui Tang, Lex H.T. Van der Ploeg, Warner Daniel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4431-4435
The discovery and optimization of a new class of non-peptidyl, pyridazinone derived melanocortin subtype-4 receptor agonists is disclosed.
Autor:
Christopher P. Austin, Doreen E. Cashen, Sheng-Shung Pong, Brian D. Spar, Brett Connolly, Tung Ming Fong, D. Euan MacIntyre, Carina P. Tan, Michael R. Tota, Ravi P. Nargund, R. S. L. Chang, Oksana C. Palyha, Constantin Tamvakopoulos, Deborah L. Drazen, Anthony G. DiLella, Jennifer E. Drisko, David J. Figueroa, Tanya MacNeil, Andreas W. Sailer, David H. Weinberg, Randy J. Nelson, Charles Rosenblum, Cathy R.-R.C. Huang, Rui Tang, Arthur A. Patchett, Xiao-Ming Guan, Hong Yu, George J. Christ, Andrew D. Howard, Lex H.T. Van der Ploeg, William J. Martin, Aurawan Vongs, Iyassu K. Sebhat, Ralph A. Stearns
Publikováno v:
Proceedings of the National Academy of Sciences. 99:11381-11386
By using a combination of genetic, pharmacological, and anatomical approaches, we show that the melanocortin 4 receptor (MC4R), implicated in the control of food intake and energy expenditure, also modulates erectile function and sexual behavior. Evi
Autor:
Xiao-Ming Guan, Charles Rosenblum, Hong Yu, Yue Feng, D. Euan MacIntyre, Alison M. Strack, Lex H.T. Van der Ploeg, Christian N. Nunes, Airu S. Chen, Joseph M. Metzger, Linhai Cao, Easter G. Frazier, Jill K. Fisher, Ramon E. Camacho, William Min, Shobhna Gopal-Truter, Aurawan Vongs, Howard Y. Chen, Theodore N. Mellin, Donald J. Marsh, Myrna E. Trumbauer
Publikováno v:
Nature Genetics. 26:97-102
Genetic and pharmacological studies have defined a role for the melanocortin-4 receptor (Mc4r) in the regulation of energy homeostasis. The physiological function of Mc3r, a melanocortin receptor expressed at high levels in the hypothalamus, has rema