Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Vonda Koka"'
Autor:
Martina Bonucci, Nicolas Kuperwasser, Serena Barbe, Vonda Koka, Delphine de Villeneuve, Chi Zhang, Nishit Srivastava, Xiaoying Jia, Matthew P. Stokes, Frank Bienaimé, Virginie Verkarre, Jean Baptiste Lopez, Fanny Jaulin, Marco Pontoglio, Fabiola Terzi, Benedicte Delaval, Matthieu Piel, Mario Pende
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
mTOR activation is known to generate polycystic kidneys, which show both increased proliferation and loss of oriented cell division (OCD). Here, Bonucci et al. show that loss of OCD is linked to S6K1 activation through its direct target Afadin and is
Externí odkaz:
https://doaj.org/article/7932503fbce7452fbc9e9d545274ef7a
Autor:
Elin Grundberg, Veronique Adoue, Tony Kwan, Bing Ge, Qing Ling Duan, Kevin C L Lam, Vonda Koka, Andreas Kindmark, Scott T Weiss, Kelan Tantisira, Hans Mallmin, Benjamin A Raby, Olle Nilsson, Tomi Pastinen
Publikováno v:
PLoS Genetics, Vol 7, Iss 1, p e1001279 (2011)
Genetic variants altering cis-regulation of normal gene expression (cis-eQTLs) have been extensively mapped in human cells and tissues, but the extent by which controlled, environmental perturbation influences cis-eQTLs is unclear. We carried out lar
Externí odkaz:
https://doaj.org/article/d8834b96a05944e6a618b7b0896a6c77
Autor:
Tony Kwan, Elin Grundberg, Vonda Koka, Bing Ge, Kevin C L Lam, Christel Dias, Andreas Kindmark, Hans Mallmin, Osten Ljunggren, Fernando Rivadeneira, Karol Estrada, Joyce B van Meurs, Andre Uitterlinden, Magnus Karlsson, Claes Ohlsson, Dan Mellström, Olle Nilsson, Tomi Pastinen, Jacek Majewski
Publikováno v:
PLoS Genetics, Vol 5, Iss 8, p e1000608 (2009)
Current genome-wide association studies (GWAS) are moving towards the use of large cohorts of primary cell lines to study a disease of interest and to assign biological relevance to the genetic signals identified. Here, we use a panel of human osteob
Externí odkaz:
https://doaj.org/article/dd00d138444348f2bbae7e5b47cd985c
Autor:
Caroline Treins, Mario Pende, Vonda Koka, Gregory Bonfils, Manuela Barilari, Sylvie Fabrega, Delphine de Villeneuve
Publikováno v:
The EMBO Journal
The inactivation of S6 kinases mimics several aspects of caloric restriction, including small body size, increased insulin sensitivity and longevity. However, the impact of S6 kinase activity on cellular senescence remains to be established. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3154c0e7a36e54cd0700336a24d923
http://europepmc.org/articles/PMC5350561
http://europepmc.org/articles/PMC5350561
Autor:
Jean-Yves Scoazec, Eric N. Olson, Mario Pende, Nicolas Pallet, Fabiola Terzi, Elizabeth P. Henske, Udayan Apte, Hilaire C. Lam, Randy L. Johnson, Patricia E Dill, Vonda Koka, Ning Liang, Chi Zhang, David J. Kwiatkowski, Delphine Pion, Morgan Gallazzini, Zheng Dong, Guido Martignoni, Ganna Panasyuk
Publikováno v:
The Journal of Experimental Medicine
Liang et al. find that the tumor suppressors TSC1 and TSC2, defects in which underlie the genetic disease Tuberous Sclerosis Complex (TSC), drive the mTOR-dependent autophagosomal destruction of the transcriptional activator YAP. Blocking YAP inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6e7261a897a97882a0bc085a504aa0
https://doi.org/10.1084/jem.20140341
https://doi.org/10.1084/jem.20140341
Autor:
Tony Kwan, Tomi Pastinen, Dominique J. Verlaan, Soizik Berlivet, Vonda Koka, Daniel Sinnett, Abeer Al Tuwaijri, Manon Ouimet, Anna K. Naumova, Sanny Moussette
Publikováno v:
Human Genetics
Phenotypic variation results from variation in gene expression, which is modulated by genetic and/or epigenetic factors. To understand the molecular basis of human disease, interaction between genetic and epigenetic factors needs to be taken into acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c27ca2ce6ec88de501bb6fef8bbd5a
https://doi.org/10.1007/s00439-012-1142-x
https://doi.org/10.1007/s00439-012-1142-x
Autor:
Cynthia Gillet, Jeffrey H. Albrecht, Céline Chauvin, Séverine Celton-Morizur, Vonda Koka, Claudia Mitchell, Mario Pende, Catherine Espeillac, Chantal Desdouets
Publikováno v:
Journal of Clinical Investigation. 121:2821-2832
Rapamycin is an antibiotic inhibiting eukaryotic cell growth and proliferation by acting on target of rapamycin (TOR) kinase. Mammalian TOR (mTOR) is thought to work through 2 independent complexes to regulate cell size and cell replication, and thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26cc687c1d1b35b1794a8c0153b9a5b7
https://doi.org/10.1172/jci44203
https://doi.org/10.1172/jci44203
Global patterns of cis variation in human cells revealed by high-density allelic expression analysis
Autor:
Robert Hamon, Marie Michele Joly, Jacek Majewski, Daniel Sinnett, Eef Harmsen, Dmitry K. Pokholok, Rose Hoberman, Jennie M. Le, Alexandre Montpetit, Mathieu Blanchette, Harald H H Göring, Anna K. Naumova, Joana Dias, Tony Kwan, Patrick Beaulieu, Edward J. Harvey, Alexandru Graziani, Dominique J. Verlaan, Tomi Pastinen, Vincent Gagné, Kevin C. L. Lam, Vonda Koka, Bing Ge, Elin Grundberg, Ken Dewar, Kevin L. Gunderson, Lisanne Morcos
Publikováno v:
Nature Genetics. 41:1216-1222
Cis-acting variants altering gene expression are a source of phenotypic differences. The cis-acting components of expression variation can be identified through the mapping of differences in allelic expression (AE), which is the measure of relative e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24532e4d8f574e96c6827d9fb854d34
https://doi.org/10.1038/ng.473
https://doi.org/10.1038/ng.473
Autor:
Mathieu Larivière, Anna K. Naumova, Tony Kwan, Gary M. Hunninghake, Kevin C. L. Lam, Daniel Sinnett, Joana Dias, Manon Ouimet, Sanny Moussette, Anne-Marie Madore, Eef Harmsen, Manuel E. Soto-Quiros, Scott T. Weiss, Ken Dewar, Juan C. Celedón, Vonda Koka, Bing Ge, Tomi Pastinen, Soizik Berlivet, Elin Grundberg, Marcin Swiatek, Lydiana Avila, Dominique J. Verlaan, Rose Hoberman, Benjamin A. Raby, Catherine Laprise
Publikováno v:
The American Journal of Human Genetics. 85(3):377-393
Common SNPs in the chromosome 17q12-q21 region alter the risk for asthma, type 1 diabetes, primary biliary cirrhosis, and Crohn disease. Previous reports by us and others have linked the disease-associated genetic variants with changes in expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d2452415bb29562dc20ae2c3b454c1
Autor:
Joyce M van Meurs, Eef Harmsen, Manon Ouimet, Daniel Sinnett, Hans Mallmin, Alexandru Graziani, Olle Nilsson, Dan Mellström, Östen Ljunggren, André G. Uitterlinden, Joana Dias, Magnus Karlsson, Patrick Beaulieu, Elin Grundberg, Tomi Pastinen, Karol Estrada, Tony Kwan, Andreas Kindmark, Vonda Koka, Kevin C. L. Lam, Claes Ohlsson, Bing Ge, Fernando Rivadeneira, Dominique J. Verlaan, Albert Hofman
Publikováno v:
Genome Research, 19(11), 1942-1952. Cold Spring Harbor Laboratory Press
The common genetic variants associated with complex traits typically lie in noncoding DNA and may alter gene regulation in a cell type-specific manner. Consequently, the choice of tissue or cell model in the dissection of disease associations is impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9d7855c53c00029e81f76b1670de6d
https://doi.org/10.1101/gr.095224.109
https://doi.org/10.1101/gr.095224.109