Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions

Autor: Von V. Phan, Charles Mosier, Michael C. Yoon, Evgenia Glukhov, Conor R. Caffrey, Anthony J. O’Donoghue, William H. Gerwick, Vivian Hook

Publikováno v: ACS omega, vol 7, iss 29

Dysregulation of cathepsin B, which involves the translocation of the enzyme from acidic pH lysosomes to the neutral pH cytosol, followed by the initiation of cell death and inflammation, occurs in numerous brain disorders. The wide difference in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c6595722843c10c428917683ae9bdd
https://escholarship.org/uc/item/64k1j9v3

Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range.

Autor: Yoon MC; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, California 92093, United States.; Biomedical Sciences Graduate Program, University of California, La Jolla, San Diego, California 92093, United States., Phan V; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, California 92093, United States.; Biomedical Sciences Graduate Program, University of California, La Jolla, San Diego, California 92093, United States., Podvin S; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, California 92093, United States., Mosier C; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, California 92093, United States., O'Donoghue AJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, California 92093, United States., Hook V; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, California 92093, United States.; Biomedical Sciences Graduate Program, University of California, La Jolla, San Diego, California 92093, United States.; Department of Neurosciences and Department of Pharmacology, School of Medicine, University of California, La Jolla, San Diego, California 92093, United States.

Publikováno v: Biochemistry [Biochemistry] 2023 Aug 01; Vol. 62 (15), pp. 2289-2300. Date of Electronic Publication: 2023 Jul 17.