Zobrazeno 1 - 10
of 854
pro vyhledávání: '"Von Kriegsheim A"'
Autor:
Agata N. Makar, Alina Boraman, Peter Mosen, Joanne E. Simpson, Jair Marques, Tim Michelberger, Stuart Aitken, Ann P. Wheeler, Dominic Winter, Alex von Kriegsheim, Noor Gammoh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Autophagy is a finely orchestrated process required for the lysosomal degradation of cytosolic components. The final degradation step is essential for clearing autophagic cargo and recycling macromolecules. Using a CRISPR/Cas9-based screen,
Externí odkaz:
https://doaj.org/article/6883251db50c4cf790616ebe8bd9529f
Autor:
Giovana Carrasco, Ifigeneia Stavrou, Mairi Treanor-Taylor, Henry Beetham, Martin Lee, Roza Masalmeh, Artur Carreras-Soldevila, David Hardman, Miguel O. Bernabeu, Alex von Kriegsheim, Gareth J. Inman, Adam Byron, Valerie G. Brunton
Publikováno v:
Oncogenesis, Vol 13, Iss 1, Pp 1-12 (2024)
Abstract Kindler syndrome (KS) is a rare genodermatosis resulting from loss-of-function mutations in FERMT1, the gene that encodes Kindlin-1. KS patients have a high propensity to develop aggressive and metastatic cutaneous squamous cell carcinoma (c
Externí odkaz:
https://doaj.org/article/8cc9d5b92cf442b7a04bdf1f0c5b321a
Autor:
Yuting Lu, Jana Travnickova, Mihaly Badonyi, Florian Rambow, Andrea Coates, Zaid Khan, Jair Marques, Laura C. Murphy, Pablo Garcia-Martinez, Richard Marais, Pakavarin Louphrasitthiphol, Alex H.Y. Chan, Christopher J. Schofield, Alex von Kriegsheim, Joseph A. Marsh, Valeria Pavet, Owen J. Sansom, Robert S. Illingworth, E. Elizabeth Patton
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114927- (2024)
Externí odkaz:
https://doaj.org/article/a0bd1226210f449ba3106f231ea41cf1
Autor:
Roly Megaw, Abigail Moye, Zhixian Zhang, Fay Newton, Fraser McPhie, Laura C. Murphy, Lisa McKie, Feng He, Melissa K. Jungnickel, Alex von Kriegsheim, Peter A. Tennant, Chloe Brotherton, Christine Gurniak, Alecia K. Gross, Laura M. Machesky, Theodore G. Wensel, Pleasantine Mill
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract As signalling organelles, cilia regulate their G protein-coupled receptor content by ectocytosis, a process requiring localised actin dynamics to alter membrane shape. Photoreceptor outer segments comprise an expanse of folded membranes (dis
Externí odkaz:
https://doaj.org/article/162f25833a9b438992ccafbff79b3556
Autor:
Eléa Gutierrez, Sharon Mitchell, Catherine Hambly, Kerry L. Sayle, Alex von Kriegsheim, John R. Speakman, Kate Britton
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110059- (2024)
Summary: This study characterized the effect of calorie restriction (CR) on elemental content and stable isotope ratio measurements of bone “collagen” and hair keratin. Adult mice on graded CR (10–40%; 84 days) showed decreased hair δ15N, δ13
Externí odkaz:
https://doaj.org/article/58c5bb42eee047ea92dee82d576f0c89
Autor:
Lu, Yuting, Travnickova, Jana, Badonyi, Mihaly, Rambow, Florian, Coates, Andrea, Khan, Zaid, Marques, Jair, Murphy, Laura C., Garcia-Martinez, Pablo, Marais, Richard, Louphrasitthiphol, Pakavarin, Chan, Alex H.Y., Schofield, Christopher J., von Kriegsheim, Alex, Marsh, Joseph A., Pavet, Valeria, Sansom, Owen J., Illingworth, Robert S., Patton, E. Elizabeth
Publikováno v:
In Cell Reports 23 July 2024 43(7)
Autor:
Raab, Michaela, Christodoulou, Ersi, Krishnankutty, Roopesh, Gradinaru, Andreea, Walker, Alexander Daniel, Olaizola, Paula, Younger, Nicholas Thomas, Lyons, Anabel Martinez, Jarman, Edward Joseph, Gournopanos, Konstantinos, von Kriegsheim, Alexander, Waddell, Scott Hamilton, Boulter, Luke
Publikováno v:
In Journal of Hepatology July 2024 81(1):108-119
Autor:
Gutierrez, Eléa, Mitchell, Sharon, Hambly, Catherine, Sayle, Kerry L., von Kriegsheim, Alex, Speakman, John R., Britton, Kate
Publikováno v:
In iScience 21 June 2024 27(6)
Autor:
Milad Ghomlaghi, Mandy Theocharous, Nhan Hoang, Sung-Young Shin, Alex von Kriegsheim, Eric O’ Neill, Tao Zhang, Lan K. Nguyen
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109031- (2024)
Summary: The transcriptional co-activator YAP forms complexes with distinct transcription factors, controlling cell fate decisions, such as proliferation and apoptosis. However, the mechanisms underlying its context-dependent function are poorly defi
Externí odkaz:
https://doaj.org/article/ac43d1e023b14adeb764bd7c42e1ff0f
Autor:
Ghomlaghi, Milad, Theocharous, Mandy, Hoang, Nhan, Shin, Sung-Young, von Kriegsheim, Alex, O’ Neill, Eric, Zhang, Tao, Nguyen, Lan K.
Publikováno v:
In iScience 15 March 2024 27(3)