Zobrazeno 1 - 10
of 872
pro vyhledávání: '"Von Hoff DD"'
Autor:
Von Hoff Dd, Erkut Borazanci
Publikováno v:
Expert Review of Gastroenterology & Hepatology. 8:739-747
Adenocarcinoma of the pancreas or pancreatic cancer as we will refer to it here, is a cancer of poor prognosis with a high mortality, particularly in the advanced or metastatic setting. Until 2011 and the Phase III results of FOLFIRINOX, standard tre
Autor:
Dragovich, T, Laheru, D, Dayyani, F, Bolejack, V, Smith, L, Seng, J, Burris, H, Rosen, P, Hidalgo, M, Ritch, P, Baker, AF, Raghunand, N, Crowley, J, Von Hoff, DD
Publikováno v:
Cancer chemotherapy and pharmacology, vol 74, iss 2
PurposeVatalanib (PTK 787/ZK22584) is an oral poly-tyrosine kinase inhibitor with strong affinity for platelet-derived growth factor and vascular endothelial growth factor (VEGF) receptors. We conducted an open-label, phase II multicenter therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::63352962c1b97bad5bbd15a5ec2725c8
https://escholarship.org/uc/item/1d01n3gr
https://escholarship.org/uc/item/1d01n3gr
Publikováno v:
Anti-Cancer Drugs. 12:133-136
Tumor types expressing a neuroendocrine phenotype secrete neuropeptides with paracrine or autocrine growth factor activity. The efficacy of these paracrine or autocrine loops depends on the expression of specific receptors on tumor cells. Once specif
Autor:
Suzanne F. Jones, Dieras, Smith L, John A. Hohneker, Eckardt, H. A. Burris, G. I. Rodriguez, Bigley J, Peacock Nw, Hardy J, Von Hoff Dd
Publikováno v:
Investigational New Drugs. 16:37-43
Vinorelbine (Navelbine®) is a unique semi-synthetic vinca-alkaloid with a favorable safety profile that has demonstrated significant antitumor activity in patients with non-small cell lung cancer, advanced breast cancer, advanced ovarian cancer and
Publikováno v:
Anti-Cancer Drugs. 5:202-206
CPT-11 (irinotecan hydrochloride, 7-ethyl-10-[4-(piperidino)-1-piperidino] carbonyloxy-camptothecin) is a semisynthetic camptothecin derivative developed in Japan. The inhibitory activity of CPT-11 against human tumor colony-forming units from freshl
Publikováno v:
Anti-Cancer Drugs. 3:143-146
2',2'-Difluorodeoxycytidine (LY 188011, Gemcitabine) is a novel pyrimidine antimetabolite with promising activity in preclinical models for leukemia and solid tumors. Phase I clinical trials with the agent are ongoing. In order to better define types
Autor:
Von Hoff Dd
Publikováno v:
Cancer Investigation. 9:521-528
Patients with malignancies or other prolonged illnesses such as acquired immune deficiency syndrome, require long-term vascular access. Unfortunately, currently available technologies which access the vascular system, such as intravenous catheters (e
Autor:
O’Shaughnessy, JA, Kelloff, GJ, Gordon, GB, Dannenberg, AJ, Hong, WK, Fabian, CJ, Sigman, CC, Bertagnolli, MM, Stratton, SP, Lam, S, Nelson, WG, Meyskens, FL, Alberts, DS, Follen, M, Rustgi, AK, Papadimitrakopoulou, V, Scardino, PT, Gazdar, AF, Wattenberg, LW, Sporn, MB, Sakr, WA, Lippman, SM, Von Hoff, DD
Publikováno v:
O’Shaughnessy, JA; Kelloff, GJ; Gordon, GB; Dannenberg, AJ; Hong, WK; Fabian, CJ; et al.(2002). Treatment and prevention of intraepithelial neoplasia: An important target for accelerated new agent development: Recommendations of the American association for cancer research Task force on the Treatment and Prevention of intraepithelial neoplasia. Clinical Cancer Research, 8(2), 314-346. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/49h1n5nx
Precancer or intraepithelial neoplasia (IEN) is a noninvasive lesion that has genetic abnormalities, loss of cellular control functions, and some phenotypic characteristics of invasive cancer and that predicts for a substantial likelihood of developi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::2aaedb1c0de26cce7f0b01f75228e98d
http://www.escholarship.org/uc/item/49h1n5nx
http://www.escholarship.org/uc/item/49h1n5nx
Autor:
Jean-Charles Soria, Eric Raymond, Laurence H. Hurley, F D Boussin, Elzbieta Izbicka, Von Hoff Dd
Publikováno v:
Investigational new drugs. 18(2)
Telomeres and telomerase have been subjects to a tremendous attention from scientists and oncologists during the past 5 years. This interest has been motivated by the potential of telomerase as a tumor marker for the diagnosis and the prognosis of ca
Autor:
Tohgo A, Gary M. Clark, Richard Lawrence, Elzbieta Izbicka, Eric K. Rowinsky, Von Hoff Dd, De Jager Rl, Steven D. Weitman
Publikováno v:
Anti-cancer drugs. 10(7)
DX-8951f, which shows great therapeutic potential, was tested in the human tumor cloning system in adult and pediatric tumor types against which topotecan has been active. In 47 tumors from adults, DX-8951f had definite cytotoxic activity in a concen