Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Von Hippel-Lindau Tumor Suppressor Protein/genetics"'
Autor:
Chantal F Morel, Saleh Albanyan, Jillian Murphy, Rachel H. Giles, Enric Mocholi Gimeno, Raymond H. Kim, Hanna Faghfoury, Jerry Machado, Josh Silver
Publikováno v:
European Journal of Medical Genetics, 62(3), 177. Elsevier Masson SAS
Von Hippel-Lindau (VHL) disease is a hereditary tumor syndrome in which carriers are at an increased risk of developing a variety of tumors in multiple organ systems. A clinical diagnosis of VHL is determined by the presence of specific clinical mani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab7422648f07979f26cca107278bc97
https://doi.org/10.1016/j.ejmg.2018.07.006
https://doi.org/10.1016/j.ejmg.2018.07.006
Autor:
Bas Havekes, Carolina R. C. Pieterman, E B Conemans, Lodewijk A.A. Brosens, Menno R. Vriens, Cathy B. Moelans, P. H. Bisschop, Lutske Lodewijk, Madeleine L. Drent, I. H. M. Borel Rinkes, H. Th. Marc Timmers, Ad R. M. M. Hermus, A. N. A. van der Horst-Schrivers, Gerlof D. Valk, Folkert H.M. Morsink, Koen M.A. Dreijerink, G. J. A. Offerhaus, W. W. de Herder, Olaf M. Dekkers
Publikováno v:
Conemans, E B, Lodewijk, L, Moelans, C B, Offerhaus, G J A, Pieterman, C R C, Morsink, F H, Dekkers, O M, De Herder, W W, Hermus, A R, Van Der Horst-Schrivers, A N, Drent, M L, Bisschop, P H, Havekes, B, Brosens, L A A, Dreijerink, K M A, Rinkes, I H M B, Timmers, H T M, Valk, G D & Vriens, M R 2018, ' DNA methylation profiling in MEN1-related pancreatic neuroendocrine tumors reveals a potential epigenetic target for treatment ', European Journal of Endocrinology, vol. 179, no. 3, pp. 153-160 . https://doi.org/10.1530/EJE-18-0195
European journal of endocrinology / European Federation of Endocrine Societies, 179(3), 153-160. BioScientifica Ltd.
European Journal of Endocrinology, 179(3), 153-160. BIOSCIENTIFICA LTD
European Journal of Endocrinology, 179, 153-160
European Journal of Endocrinology, 179(3), 153-160
European Journal of Endocrinology, 179, 3, pp. 153-160
European Journal of Endocrinology, 179(3), 153-160. Bioscientifica Ltd
European Journal of Endocrinology, 179(3), 153-160. BioScientifica Ltd.
European Journal of Endocrinology, 179(3), 153. BioScientifica Ltd.
Conemans, E B, Lodewijk, L, Moelans, C B, Offerhaus, G J A, Pieterman, C R C, Morsink, F H, Dekkers, O M, de Herder, W W, Hermus, A R, van der Horst-Schrivers, A N, Drent, M L, Bisschop, P H, Havekes, B, Brosens, L A A, Dreijerink, K M A, Borel Rinkes, I H M, Timmers, H T M, Valk, G D & Vriens, M R 2018, ' DNA methylation profiling in MEN1-related pancreatic neuroendocrine tumors reveals a potential epigenetic target for treatment ', European Journal of Endocrinology, vol. 179, no. 3, pp. 153-160 . https://doi.org/10.1530/EJE-18-0195
European journal of endocrinology / European Federation of Endocrine Societies, 179(3), 153-160. BioScientifica Ltd.
European Journal of Endocrinology, 179(3), 153-160. BIOSCIENTIFICA LTD
European Journal of Endocrinology, 179, 153-160
European Journal of Endocrinology, 179(3), 153-160
European Journal of Endocrinology, 179, 3, pp. 153-160
European Journal of Endocrinology, 179(3), 153-160. Bioscientifica Ltd
European Journal of Endocrinology, 179(3), 153-160. BioScientifica Ltd.
European Journal of Endocrinology, 179(3), 153. BioScientifica Ltd.
Conemans, E B, Lodewijk, L, Moelans, C B, Offerhaus, G J A, Pieterman, C R C, Morsink, F H, Dekkers, O M, de Herder, W W, Hermus, A R, van der Horst-Schrivers, A N, Drent, M L, Bisschop, P H, Havekes, B, Brosens, L A A, Dreijerink, K M A, Borel Rinkes, I H M, Timmers, H T M, Valk, G D & Vriens, M R 2018, ' DNA methylation profiling in MEN1-related pancreatic neuroendocrine tumors reveals a potential epigenetic target for treatment ', European Journal of Endocrinology, vol. 179, no. 3, pp. 153-160 . https://doi.org/10.1530/EJE-18-0195
ObjectiveEpigenetic changes contribute to pancreatic neuroendocrine tumor (PanNET) development. Hypermethylation of promoter DNA as a cause of tumor suppressor gene silencing is a well-established oncogenic mechanism that is potentially reversible an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70073bddb0cfac1bc8627a5638d3af2a
https://doi.org/10.1530/eje-18-0195
https://doi.org/10.1530/eje-18-0195
Autor:
Esther Korpershoek, Eleonora P M Corssmit, Cees J. Cornelisse, Henri J L M Timmers, Jeroen C. Jansen, Adrian Bateman, Erik F. Hensen, Ekaterina S. Jordanova, Jean-Pierre Bayley, Peter Devilee, Diana Eccles, Henricus P. M. Kunst, Attje S. Hoekstra, Frederik J. Hes, Anouk N A van der Horst-Schrivers, Judith V.M.G. Bovée
Publikováno v:
Oncotarget, 8(9), 14525-14536. Impact Journals
Oncotarget, 8(9), 14525-14536. Impact Journals LLC
Oncotarget, 8, 14525-14536
Oncotarget
Hoekstra, A S, Hensen, E F, Jordanova, E S, Korpershoek, E, van der Horst-Schrivers, A N A, Cornelisse, C, Corssmit, E P M, Hes, F J, Jansen, J C, Kunst, H P M, Timmers, H J L M, Bateman, A, Eccles, D, Bovee, J V M G, Devilee, P & Bayley, J-P 2017, ' Loss of maternal chromosome 11 is a signature event in SDHAF2, SDHD, and VHL-related paragangliomas, but less significant in SDHB-related paragangliomas ', Oncotarget, vol. 8, no. 9, pp. 14525-14536 . https://doi.org/10.18632/oncotarget.14649
Oncotarget, 8, 9, pp. 14525-14536
Oncotarget, 8(9), 14525-14536
Oncotarget, 8(9), 14525-14536. Impact Journals LLC
Oncotarget, 8, 14525-14536
Oncotarget
Hoekstra, A S, Hensen, E F, Jordanova, E S, Korpershoek, E, van der Horst-Schrivers, A N A, Cornelisse, C, Corssmit, E P M, Hes, F J, Jansen, J C, Kunst, H P M, Timmers, H J L M, Bateman, A, Eccles, D, Bovee, J V M G, Devilee, P & Bayley, J-P 2017, ' Loss of maternal chromosome 11 is a signature event in SDHAF2, SDHD, and VHL-related paragangliomas, but less significant in SDHB-related paragangliomas ', Oncotarget, vol. 8, no. 9, pp. 14525-14536 . https://doi.org/10.18632/oncotarget.14649
Oncotarget, 8, 9, pp. 14525-14536
Oncotarget, 8(9), 14525-14536
// Attje S. Hoekstra 1 , Erik F. Hensen 2 , Ekaterina S. Jordanova 3 , Esther Korpershoek 4 , Anouk N.A. van der Horst-Schrivers 5 , Cees Cornelisse 3 , Eleonora P.M. Corssmit 6 , Frederik J. Hes 7 , Jeroen C. Jansen 8 , Henricus P.M. Kunst 9 , Henri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5923c85f5043a05855990265428c80e3
https://doi.org/10.18632/oncotarget.14649
https://doi.org/10.18632/oncotarget.14649
Autor:
Peter Mirtschink, Rahul Sharma, Geetha Rossi, Sanjay Khadayate, Corinne Berthonneche, Eman Hagag, Wilhelm Krek, Corinne Bischof, Jaya Krishnan, Thierry Pedrazzini, Samuel Sossalla, Phillip Grote, Shuyang Traub, Niklaus Fankhauser, Alexandre Sarre, Sebastian Stehr, Stefanie Dimmeler, Minh Duc Pham
Publikováno v:
Circulation, vol. 139, no. 24, pp. 2778-2792
Circulation
Circulation, 139 (24)
Circulation
Circulation, 139 (24)
Supplemental Digital Content is available in the text.
Background: Enhancers are genomic regulatory elements conferring spatiotemporal and signal-dependent control of gene expression. Recent evidence suggests that enhancers can generate noncodin
Background: Enhancers are genomic regulatory elements conferring spatiotemporal and signal-dependent control of gene expression. Recent evidence suggests that enhancers can generate noncodin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d25d4a747aa8a59989af7a0718498f
https://serval.unil.ch/resource/serval:BIB_BAE7C7F2C66F.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_BAE7C7F2C66F.P001/REF.pdf
Autor:
Anne-Marie Gerdes, Karin Wadt, Maria Bejerholm Christensen, Lotte Nylandsted Krogh, Uffe Birk Jensen, Charlotte Kvist Lautrup, Anders Bojesen, Thomas van Overeem Hansen
Publikováno v:
Christensen, M B, Wadt, K, Jensen, U B, Lautrup, C K, Bojesen, A, Krogh, L N, van Overeem Hansen, T & Gerdes, A M 2019, ' Exploring the hereditary background of renal cancer in Denmark ', PLOS ONE, vol. 14, no. 4, e0215725 . https://doi.org/10.1371/journal.pone.0215725
PLoS ONE
Christensen, M B, Wadt, K, Jensen, U B, Lautrup, C K, Bojesen, A, Krogh, L N, Overeem Hansen, T V & Gerdes, A-M 2019, ' Exploring the hereditary background of renal cancer in Denmark ', PLoS ONE, vol. 14, no. 4, e0215725 . https://doi.org/10.1371/journal.pone.0215725
Christensen, M B, Wadt, K, Jensen, U B, Lautrup, C K, Bojesen, A, Krogh, L N, Overeem Hansen, T V & Gerdes, A-M 2019, ' Exploring the hereditary background of renal cancer in Denmark ', PLOS ONE, vol. 14, no. 4, e0215725, pp. 1-16 . https://doi.org/10.1371/journal.pone.0215725
Christensen, M B, Wadt, K, Jensen, U B, Lautrup, C K, Bojesen, A, Krogh, L N, Overeem Hansen, T V & Gerdes, A-M 2019, ' Exploring the hereditary background of renal cancer in Denmark ', PLOS ONE, vol. 14, no. 4, e0215725 . https://doi.org/10.1371/journal.pone.0215725
PLoS ONE, Vol 14, Iss 4, p e0215725 (2019)
PLoS ONE
Christensen, M B, Wadt, K, Jensen, U B, Lautrup, C K, Bojesen, A, Krogh, L N, Overeem Hansen, T V & Gerdes, A-M 2019, ' Exploring the hereditary background of renal cancer in Denmark ', PLoS ONE, vol. 14, no. 4, e0215725 . https://doi.org/10.1371/journal.pone.0215725
Christensen, M B, Wadt, K, Jensen, U B, Lautrup, C K, Bojesen, A, Krogh, L N, Overeem Hansen, T V & Gerdes, A-M 2019, ' Exploring the hereditary background of renal cancer in Denmark ', PLOS ONE, vol. 14, no. 4, e0215725, pp. 1-16 . https://doi.org/10.1371/journal.pone.0215725
Christensen, M B, Wadt, K, Jensen, U B, Lautrup, C K, Bojesen, A, Krogh, L N, Overeem Hansen, T V & Gerdes, A-M 2019, ' Exploring the hereditary background of renal cancer in Denmark ', PLOS ONE, vol. 14, no. 4, e0215725 . https://doi.org/10.1371/journal.pone.0215725
PLoS ONE, Vol 14, Iss 4, p e0215725 (2019)
BACKGROUND: Every year more than 800 patients in Denmark are diagnosed with renal cell carcinoma (RCC) of which 3-5% are expected to be part of a hereditary renal cancer syndrome. We performed genetic screening of causative and putative RCC-genes (VH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65de305f7a1331ad5ebebe9680f07da2
https://pure.au.dk/portal/da/publications/exploring-the-hereditary-background-of-renal-cancer-in-denmark(1c2b74dd-9779-4823-a2eb-95b1a027ea4b).html
https://pure.au.dk/portal/da/publications/exploring-the-hereditary-background-of-renal-cancer-in-denmark(1c2b74dd-9779-4823-a2eb-95b1a027ea4b).html