Arid5a uses disordered extensions of its core ARID domain for distinct DNA- and RNA-recognition and gene regulation.

Autor: von Ehr J; Institute for Molecular Biosciences and Biomolecular Resonance Center (BMRZ), Goethe University Frankfurt, Frankfurt, Germany; IMPRS on Cellular Biophysics, Frankfurt, Germany., Oberstrass L; University of Marburg, Department of Pharmacy, Institute of Pharmaceutical Chemistry, Marburg, Germany., Yazgan E; Institute for Molecular Biosciences, Goethe University Frankfurt, Frankfurt, Germany; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany., Schnaubelt LI; Institute for Molecular Biosciences and Biomolecular Resonance Center (BMRZ), Goethe University Frankfurt, Frankfurt, Germany., Blümel N; Institute for Molecular Biosciences, Goethe University Frankfurt, Frankfurt, Germany., McNicoll F; Institute for Molecular Biosciences, Goethe University Frankfurt, Frankfurt, Germany., Weigand JE; University of Marburg, Department of Pharmacy, Institute of Pharmaceutical Chemistry, Marburg, Germany., Zarnack K; Institute for Molecular Biosciences, Goethe University Frankfurt, Frankfurt, Germany; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany., Müller-McNicoll M; Institute for Molecular Biosciences, Goethe University Frankfurt, Frankfurt, Germany; Max-Planck Institute for Biophysics, Frankfurt, Germany., Korn SM; Institute for Molecular Biosciences and Biomolecular Resonance Center (BMRZ), Goethe University Frankfurt, Frankfurt, Germany; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA. Electronic address: smk2305@cumc.columbia.edu., Schlundt A; Institute for Molecular Biosciences and Biomolecular Resonance Center (BMRZ), Goethe University Frankfurt, Frankfurt, Germany; University of Greifswald, Institute of Biochemistry, Greifswald, Germany. Electronic address: schlundt@bio.uni-frankfurt.de.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2024 Jul; Vol. 300 (7), pp. 107457. Date of Electronic Publication: 2024 Jun 10.

Insight into the Structural Basis for Dual Nucleic Acid-Recognition by the Scaffold Attachment Factor B2 Protein.

Autor: Korn SM; Institute for Molecular Biosciences, Biomolecular Resonance Center (BMRZ), Goethe University Frankfurt, Max-von-Laue-Str. 7-9, 60438 Frankfurt, Germany., Von Ehr J; Institute for Molecular Biosciences, Biomolecular Resonance Center (BMRZ), Goethe University Frankfurt, Max-von-Laue-Str. 7-9, 60438 Frankfurt, Germany.; IMPRS on Cellular Biophysics, Max-von-Laue-Str. 7-9, 60438 Frankfurt, Germany., Dhamotharan K; Institute for Molecular Biosciences, Biomolecular Resonance Center (BMRZ), Goethe University Frankfurt, Max-von-Laue-Str. 7-9, 60438 Frankfurt, Germany., Tants JN; Institute for Molecular Biosciences, Biomolecular Resonance Center (BMRZ), Goethe University Frankfurt, Max-von-Laue-Str. 7-9, 60438 Frankfurt, Germany., Abele R; Institute for Biochemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany., Schlundt A; Institute for Molecular Biosciences, Biomolecular Resonance Center (BMRZ), Goethe University Frankfurt, Max-von-Laue-Str. 7-9, 60438 Frankfurt, Germany.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 07; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 07.

Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma.

Autor: Ravi VM; Microenvironment and Immunology Research Laboratory, Medical Center - University of Freiburg, Freiburg, Germany; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Translational NeuroOncology Research Group, Medical Center - University of Freiburg, Freiburg, Germany; Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Freiburg, Germany; Center of Advanced Surgical Tissue Analysis (CAST), University of Freiburg, Freiburg, Germany., Will P; Microenvironment and Immunology Research Laboratory, Medical Center - University of Freiburg, Freiburg, Germany; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Translational NeuroOncology Research Group, Medical Center - University of Freiburg, Freiburg, Germany., Kueckelhaus J; Microenvironment and Immunology Research Laboratory, Medical Center - University of Freiburg, Freiburg, Germany; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Translational NeuroOncology Research Group, Medical Center - University of Freiburg, Freiburg, Germany; Neurosurgical Artificial Intelligence Laboratory Aachen (NAILA), Department of Neurosurgery, RWTH University of Aachen, Aachen, Germany., Sun N; Research Unit Analytical Pathology, Helmholtz Zentrum München, Neuherberg, Germany., Joseph K; Microenvironment and Immunology Research Laboratory, Medical Center - University of Freiburg, Freiburg, Germany; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Translational NeuroOncology Research Group, Medical Center - University of Freiburg, Freiburg, Germany; Center of Advanced Surgical Tissue Analysis (CAST), University of Freiburg, Freiburg, Germany., Salié H; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Medicine II: Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, Medical Center - University of Freiburg, Freiburg, Germany., Vollmer L; Microenvironment and Immunology Research Laboratory, Medical Center - University of Freiburg, Freiburg, Germany; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Translational NeuroOncology Research Group, Medical Center - University of Freiburg, Freiburg, Germany., Kuliesiute U; Microenvironment and Immunology Research Laboratory, Medical Center - University of Freiburg, Freiburg, Germany; Translational NeuroOncology Research Group, Medical Center - University of Freiburg, Freiburg, Germany; The Institute of Biosciences, Life Sciences Center, Vilnius University, Vilnius, Lithuania., von Ehr J; Microenvironment and Immunology Research Laboratory, Medical Center - University of Freiburg, Freiburg, Germany; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Translational NeuroOncology Research Group, Medical Center - University of Freiburg, Freiburg, Germany., Benotmane JK; Microenvironment and Immunology Research Laboratory, Medical Center - University of Freiburg, Freiburg, Germany; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Translational NeuroOncology Research Group, Medical Center - University of Freiburg, Freiburg, Germany., Neidert N; Microenvironment and Immunology Research Laboratory, Medical Center - University of Freiburg, Freiburg, Germany; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Translational NeuroOncology Research Group, Medical Center - University of Freiburg, Freiburg, Germany., Follo M; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Medicine I, Medical Center - University of Freiburg, Freiburg, Germany., Scherer F; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Medicine I, Medical Center - University of Freiburg, Freiburg, Germany., Goeldner JM; Microenvironment and Immunology Research Laboratory, Medical Center - University of Freiburg, Freiburg, Germany; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Translational NeuroOncology Research Group, Medical Center - University of Freiburg, Freiburg, Germany., Behringer SP; Microenvironment and Immunology Research Laboratory, Medical Center - University of Freiburg, Freiburg, Germany; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Translational NeuroOncology Research Group, Medical Center - University of Freiburg, Freiburg, Germany., Franco P; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Translational NeuroOncology Research Group, Medical Center - University of Freiburg, Freiburg, Germany., Khiat M; Microenvironment and Immunology Research Laboratory, Medical Center - University of Freiburg, Freiburg, Germany; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Translational NeuroOncology Research Group, Medical Center - University of Freiburg, Freiburg, Germany., Zhang J; Microenvironment and Immunology Research Laboratory, Medical Center - University of Freiburg, Freiburg, Germany; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Translational NeuroOncology Research Group, Medical Center - University of Freiburg, Freiburg, Germany., Hofmann UG; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Neuroelectronic Systems, Medical Center - University of Freiburg, Freiburg, Germany., Fung C; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany., Ricklefs FL; Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany; Laboratory for Brain Tumor Biology, University Hospital Eppendorf, Hamburg, Germany., Lamszus K; Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany; Laboratory for Brain Tumor Biology, University Hospital Eppendorf, Hamburg, Germany., Boerries M; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Freiburg, Germany; Comprehensive Cancer Center Freiburg (CCCF), Medical Center - University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), partner site Freiburg, Freiburg, Germany., Ku M; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center - University of Freiburg, Freiburg, Germany., Beck J; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for NeuroModulation (NeuroModul), University of Freiburg, Freiburg, Germany; Center of Advanced Surgical Tissue Analysis (CAST), University of Freiburg, Freiburg, Germany., Sankowski R; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Institute of Neuropathology, Medical Center - University of Freiburg, Freiburg, German., Schwabenland M; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Institute of Neuropathology, Medical Center - University of Freiburg, Freiburg, German., Prinz M; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for NeuroModulation (NeuroModul), University of Freiburg, Freiburg, Germany; Institute of Neuropathology, Medical Center - University of Freiburg, Freiburg, German; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany., Schüller U; Institute of Neuropathology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany; Research Institute Children's Cancer Center, Hamburg, Germany; Department of Pediatric Hematology and Oncology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Killmer S; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Medicine II: Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, Medical Center - University of Freiburg, Freiburg, Germany., Bengsch B; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Medicine II: Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, Medical Center - University of Freiburg, Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany., Walch AK; Research Unit Analytical Pathology, Helmholtz Zentrum München, Neuherberg, Germany., Delev D; Neurosurgical Artificial Intelligence Laboratory Aachen (NAILA), Department of Neurosurgery, RWTH University of Aachen, Aachen, Germany; Department of Neurosurgery, RWTH University of Aachen, Aachen, Germany., Schnell O; Microenvironment and Immunology Research Laboratory, Medical Center - University of Freiburg, Freiburg, Germany; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Translational NeuroOncology Research Group, Medical Center - University of Freiburg, Freiburg, Germany; Center of Advanced Surgical Tissue Analysis (CAST), University of Freiburg, Freiburg, Germany., Heiland DH; Microenvironment and Immunology Research Laboratory, Medical Center - University of Freiburg, Freiburg, Germany; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Comprehensive Cancer Center Freiburg (CCCF), Medical Center - University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), partner site Freiburg, Freiburg, Germany; Center of Advanced Surgical Tissue Analysis (CAST), University of Freiburg, Freiburg, Germany. Electronic address: dieter.henrik.heiland@uniklinik-freiburg.de.

Publikováno v: Cancer cell [Cancer Cell] 2022 Jun 13; Vol. 40 (6), pp. 639-655.e13.

Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma.

Autor: Maier JP; Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Translational NeuroOncology Research Group, Medical Center-University of Freiburg, Freiburg, Germany., Ravi VM; Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Translational NeuroOncology Research Group, Medical Center-University of Freiburg, Freiburg, Germany.; Neuroelectronic Systems, Medical Center-University of Freiburg, Freiburg, Germany., Kueckelhaus J; Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Translational NeuroOncology Research Group, Medical Center-University of Freiburg, Freiburg, Germany., Behringer SP; Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Translational NeuroOncology Research Group, Medical Center-University of Freiburg, Freiburg, Germany., Garrelfs N; Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Translational NeuroOncology Research Group, Medical Center-University of Freiburg, Freiburg, Germany., Will P; Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Translational NeuroOncology Research Group, Medical Center-University of Freiburg, Freiburg, Germany., Sun N; Research Unit Analytical Pathology, Helmholtz Zentrum München, Neuherberg, Germany., von Ehr J; Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Translational NeuroOncology Research Group, Medical Center-University of Freiburg, Freiburg, Germany., Goeldner JM; Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Translational NeuroOncology Research Group, Medical Center-University of Freiburg, Freiburg, Germany., Pfeifer D; Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center-University of Freiburg, Freiburg, Germany., Follo M; Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Department of Medicine I, Medical Center-University of Freiburg, Freiburg, Germany., Hannibal L; Laboratory of Clinical Biochemistry and Metabolism, Department of General Pediatrics, Adolescent Medicine and Neonatology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Walch AK; Research Unit Analytical Pathology, Helmholtz Zentrum München, Neuherberg, Germany., Hofmann UG; Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Neuroelectronic Systems, Medical Center-University of Freiburg, Freiburg, Germany., Beck J; Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany., Heiland DH; Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany., Schnell O; Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Translational NeuroOncology Research Group, Medical Center-University of Freiburg, Freiburg, Germany., Joseph K; Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany. kevin.joseph@uniklinik-freiburg.de.; Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany. kevin.joseph@uniklinik-freiburg.de.; Faculty of Medicine, University of Freiburg, Freiburg, Germany. kevin.joseph@uniklinik-freiburg.de.; Translational NeuroOncology Research Group, Medical Center-University of Freiburg, Freiburg, Germany. kevin.joseph@uniklinik-freiburg.de.; Neuroelectronic Systems, Medical Center-University of Freiburg, Freiburg, Germany. kevin.joseph@uniklinik-freiburg.de.

Publikováno v: Cell death & disease [Cell Death Dis] 2021 Jul 21; Vol. 12 (8), pp. 723. Date of Electronic Publication: 2021 Jul 21.

The Three Pillars of Glioblastoma: A Systematic Review and Novel Analysis of Multi-Omics and Clinical Data.

Autor: De Luca, Ciro¹ (AUTHOR) assunta.virtuoso@unicampania.it, Virtuoso, Assunta¹ (AUTHOR) michele.papa@unicampania.it, Papa, Michele^1,2 (AUTHOR) giovanni.cirillo@unicampania.it, Cirillo, Giovanni¹ (AUTHOR), La Rocca, Giuseppe³ (AUTHOR) giuseppe.larocca@policlinicogemelli.it, Corvino, Sergio⁴ (AUTHOR) sercorvino@gmail.com, Barbarisi, Manlio⁵ (AUTHOR) roberto.altieri@unicampania.it, Altieri, Roberto⁵ (AUTHOR)

Publikováno v: Cells (2073-4409). Nov2024, Vol. 13 Issue 21, p1754. 17p.