Zobrazeno 1 - 10
of 12 451
pro vyhledávání: '"Volume of distribution"'
Autor:
Rohit Bhowmick, Sasidaran Kandasamy
Publikováno v:
Journal of Pediatric Critical Care, Vol 11, Iss 5, Pp 227-232 (2024)
Toxic and prescribed drug ingestions are a significant cause of pediatric morbidity and mortality. Management of the poisoned patient begins with a thorough evaluation, identification of the agent(s) involved, and assessment of severity and symptoms.
Externí odkaz:
https://doaj.org/article/4b7a75b244b4451dafb53de5eb191acc
Publikováno v:
Infectious Diseases and Therapy, Vol 13, Iss 8, Pp 1807-1819 (2024)
Abstract Introduction Methicillin-resistant Staphylococcus aureus (MRSA) infections are a serious threat to public health. Vancomycin (VAN) remains the primary treatment for these infections, and achieving the recommended area under the curve (AUC) t
Externí odkaz:
https://doaj.org/article/9a7f1bb7c226400ba2c7c0931dfc611c
Autor:
Manon Launay, Edouard Ollier, Benjamin Kably, Félicien Le Louedec, Guillaume Thiery, Julien Lanoiselée, Sophie Perinel-Ragey
Publikováno v:
Antibiotics, Vol 13, Iss 8, p 756 (2024)
To rapidly achieve ceftazidime target concentrations, a 2 g loading dose (LD) is recommended before continuous infusion, but its adequacy in critically ill patients, given their unique pharmacokinetics, needs investigation. This study included patien
Externí odkaz:
https://doaj.org/article/899ae649ff2f440da9da15e023933067
Autor:
Tjokosela Tikiso, Valentin Fuhrmann, Christina König, Dominik Jarczak, Stefanie Iwersen-Bergmann, Stefan Kluge, Sebastian G. Wicha, Jörn Grensemann
Publikováno v:
Annals of Intensive Care, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Background In acute-on-chronic liver failure (ACLF), adequate antibiotic dosing is challenging due to changes of drug distribution and elimination. We studied the pharmacokinetics of linezolid in critically ill patients with ACLF during cont
Externí odkaz:
https://doaj.org/article/9101e6a64ee147c793ab3d1e070406b1
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 973 (2024)
Glioblastoma remains a devastating disease with a bleak prognosis despite continued research and numerous clinical trials. Convection-enhanced delivery offers researchers and clinicians a platform to bypass the blood–brain barrier and administer dr
Externí odkaz:
https://doaj.org/article/b94e5f7c13ac4ce7a69df87e089fbd3b
Publikováno v:
مجلة كلية الطب, Vol 65, Iss 4 (2024)
Background: Preeclampsia is a pregnancy-specific, multisystem condition characterized by the onset of de novo hypertension and proteinuria occurring in previously normotensive women after the twentieth week of pregnancy. Pregnancy is associated with
Externí odkaz:
https://doaj.org/article/45897ba4d34d44b19d13fabb9cbad6f6
Publikováno v:
Journal of Pharmacy & Pharmacognosy Research, Vol 11, Iss 1, Pp 160-178 (2023)
Context: Pharmacokinetic studies play a fundamental role in making informed decisions during the drug development stage and fulfilling regulatory agencies’ requirements for drug approval. Disposition profiles of plasma drug concentrations over time
Externí odkaz:
https://doaj.org/article/49c7234113d64f9ab4724beb03b4a016
Autor:
Natalia V. Bakulina, Sergey V. Tikhonov, Sergey V. Okovityi, Elena A. Lutaenko, Alexandеr O. Bolshakov, Veronika A. Prikhodko, Anna S. Nekrasova
Publikováno v:
Терапевтический архив, Vol 94, Iss 12, Pp 1431-1437 (2023)
The MedLine database contains 570 publications, including 71 randomized clinical trials and 6 meta-analyses on the rebamipide molecule in 2022. Indications for the use of rebamipide are gastric ulcer, chronic gastritis with hyperacidityin the acute s
Externí odkaz:
https://doaj.org/article/854065ccdd4f4d0788bc00d7afd90d2c
Publikováno v:
The Journal of Critical Care Medicine, Vol 8, Iss 4, Pp 288-291 (2022)
Patients with severe coronavirus disease 2019 (COVID-19) receiving ventilation or pulmonary support via veno-venous extracorporeal membrane oxygenation (VV-ECMO) can be infected with drug-resistant bacteria. When introducing VV-ECMO, the changes in s
Externí odkaz:
https://doaj.org/article/ffc62c85c12a4db7a070b32de2fb930a
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 128 (2024)
This commentary further reflects on the paper of De Sutter et al. on predicting volume of distribution in neonates, and the performance of physiologically based pharmacokinetic models We hereby stressed the add on value to collaborate on real world d
Externí odkaz:
https://doaj.org/article/babb958d9cdd43d3a728bd820082bef0