Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Volodymyr S. Brovarets"'
Publikováno v:
Current Chemistry Letters, Vol 13, Iss 4, Pp 695-706 (2024)
It has been reported that the halogen dance reaction can be used to synthesize polyfunctionalized 1,3-thiazoles. The transformation into target products was carried out by lithiation of 2-bromo-5-(1,3-dioxolan-2-yl)-1,3-thiazole with lithium diisopro
Externí odkaz:
https://doaj.org/article/9c6cad2a7491434ebbf9ede9327a8cf6
Autor:
Olena V. Savych, Anastasia V. Gryniukova, Diana O. Alieksieieva, Igor M. Dziuba, Petro O. Borysko, Dmytro V. Dudenko, Volodymyr S. Brovarets, Yurii S. Moroz
Publikováno v:
Журнал органічної та фармацевтичної хімії, Vol 19, Iss 4, Pp 3-11 (2021)
Aim. To demonstrate the advantages of large-scale virtual libraries generated using chemical protocols previously validated in primary steps of the drug discovery process. Results and discussion. Two validated parallel chemistry protocols reported e
Externí odkaz:
https://doaj.org/article/88cc6ab66db446b0aa20dc242b95d679
Publikováno v:
Журнал органічної та фармацевтичної хімії, Vol 18, Iss 3, Pp 3-24 (2020)
Functionalization of heterocyclic systems with sulfur- and phosphorus-containing pharmacophores has long shown itself as an effective method for construction of new bioactive substances. At the same time, some types of the compounds are represented b
Externí odkaz:
https://doaj.org/article/41f684d384f842ecb3299a344cd42136
Autor:
Oleksandr V. Golovchenko, Esma R. Abdurakhmanova, Mykhailo Y. Brusnakov, Serhii O. Vladimirov, Yulia O. Shyshatska, Olga V. Khilya, Yulian M. Volovenko, Volodymyr S. Brovarets
Publikováno v:
Current Chemistry Letters, Vol 9, Iss 3, Pp 131-142 (2020)
The interaction of (2-aryl-5-(hydroxyalkylamino)-1,3-oxazol-4-yl)phosphonates with hydrogen chloride, hydrogen iodide and hydrogen thiocyanate in anhydrous medium led to formation of new phosphorylated peptidomimetics containing C-terminal ω-haloalk
Externí odkaz:
https://doaj.org/article/9ed19d60fcfd47a1a95ce6d53be46e83
Autor:
Oleh V. Shablykin, Yurii Eu. Kornii, Victoriya V. Dyakonenko, Olga V. Shablykina, Volodymyr S. Brovarets
Publikováno v:
Current Chemistry Letters, Vol 8, Iss 4, Pp 199-210 (2019)
Obtained by the interaction of 2-amino-3,3-dichloroacrylonitrile and chlorosulphonyl isocyanate (Z)-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride reacts easily with excess of the aliphatic amine to form new (Z)-N-(5-(dichlorom
Externí odkaz:
https://doaj.org/article/0348478cbfbe477ba6ea2eaa21d3ce6b
Autor:
Larysa O. Metelytsia, Diana M. Hodyna, Ivan V. Semenyuta, Vasyl V. Kovalishyn, Sergiy P. Rogalsky, Kateryna Yu Derevianko, Volodymyr S. Brovarets, Igor V. Tetko
Publikováno v:
Antibiotics, Vol 11, Iss 4, p 491 (2022)
A previously developed model to predict antibacterial activity of ionic liquids against a resistant A. baumannii strain was used to assess activity of phosphonium ionic liquids. Their antioxidant potential was additionally evaluated with newly develo
Externí odkaz:
https://doaj.org/article/4d083075b2f14074aee1cc0dcc6bca4f
Autor:
Maryna Kachaeva, Stepan Pilyo, Sergiy Popilnichenko, Andrii Kornienko, Eduard Rusanov, Volodymyr Prokopenko, Vladimir Zyabrev, Volodymyr S. Brovarets
Publikováno v:
Current Chemistry Letters, Vol 7, Iss 4, Pp 101-110 (2018)
Reaction of methyl 2-aryl-5-(chlorosulfonyl)-1,3-oxazole-4-carboxylates with 1H-pyrazol-5-amines and 1H-1,2,4-triazol-5-amines proceeds with the participation of endocyclic aminoazole nitrogen atoms to yield products containing a primary amino group.
Externí odkaz:
https://doaj.org/article/0c7caff22a474872ba7bdfd3aa659e10
Publikováno v:
Current Chemistry Letters, Vol 7, Iss 1, Pp 1-8 (2018)
The reaction of lithiation of 2-bromo-4-(1,3-dioxolan-2-yl)-1,3-thiazole with in position 5 of the thiazole ring and double lithiation with t-butyllithium (t-BuLi) in positions 2 and 5 lithium diisopropylamide (LDA) are investigated. When lithiated a
Externí odkaz:
https://doaj.org/article/461c555804d243099a00fd73fc43ef77
Publikováno v:
Current Chemistry Letters, Vol 6, Iss 2, Pp 49-54 (2017)
Readily available tetrachloro-2-aza-1,3-butadienes enter into directed cyclocondensation reaction with N-phenyl-1,2-cyclopentanediamine which leads to regioselective cyclopentane annulation by the 1,3,5-triazepine. The formation of the 1,3,5-triazepi
Externí odkaz:
https://doaj.org/article/d52ae5717f9b4ba2b543478e59392b6b
Autor:
Ivan V. Semenyuta, Oleksandr L. Kobzar, Diana M. Hodyna, Volodymyr S. Brovarets, Larysa O. Metelytsia
Publikováno v:
Heliyon, Vol 5, Iss 4, Pp e01462- (2019)
In this study, the synthesis, in vitro anti-Candida activity and molecular modeling of 4-phosphorylated derivatives of 1,3-oxazole as inhibitors of Candida albicans fructose-1,6-bisphosphate aldolase (FBA-II) are demonstrated and discussed. Significa
Externí odkaz:
https://doaj.org/article/a14d5559cd49475c9aa4a1f4889b6a40