Výsledky vyhledávání - "Volodymyr Kucher"

Akademický článek

Restrictive expression of acid-sensing ion channel 5 (asic5) in unipolar brush cells of the vestibulocerebellum.

Autor: Nina Boiko, Volodymyr Kucher, Bin Wang, James D Stockand

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e91326 (2014)

Acid-sensing ion channels (Asic) are ligand-gated ion channels in the Degenerin/Epithelial Na+ channel (Deg/ENaC) family. Asic proteins are richly expressed in mammalian neurons. Mammals express five Asic genes: Asic1-5. The gene product of Asic5 is

Externí odkaz: https://doaj.org/article/a81313dd5f1c4bf1a46de8517a826438

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Inhibition of Neuronal Degenerin/Epithelial Na+ Channels by the Multiple Sclerosis Drug 4-Aminopyridine

Autor: Benjamin A. Eaton, Volodymyr Kucher, Nina Boiko, James D. Stockand

Publikováno v: Journal of Biological Chemistry. 288:9418-9427

The voltage-gated K(+) (Kv) channel blocker 4-aminopyridine (4-AP) is used to target symptoms of the neuroinflammatory disease multiple sclerosis (MS). By blocking Kv channels, 4-AP facilitates action potential conduction and neurotransmitter release

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88780de389c34be6b51ef97439a6a13b
https://doi.org/10.1074/jbc.m112.449413

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Pickpocket1 Is an Ionotropic Molecular Sensory Transducer

Autor: Nina Boiko, Volodymyr Kucher, James D. Stockand, Benjamin A. Eaton

Publikováno v: Journal of Biological Chemistry. 287:39878-39886

The molecular transformation of an external stimulus into changes in sensory neuron activity is incompletely described. Although a number of molecules have been identified that can respond to stimuli, evidence that these molecules can transduce stimu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581686440558bbfbe6e6c0a5e6785d0f
https://doi.org/10.1074/jbc.m112.411736

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The role of aspartic acid residues 405 and 416 of the kidney isotype of sodium-bicarbonate cotransporter 1 in its targeting to the plasma membrane

Autor: Emily Y. Li, Manoocher Soleimani, Volodymyr Kucher, Laura Conforti, Hong C. Li, Kamyar Zahedi

Publikováno v: American Journal of Physiology-Cell Physiology. 302:C1713-C1730

The NH2 terminus of the sodium-bicarbonate cotransporter 1 (NBCe1) plays an important role in its targeting to the plasma membrane. To identify the amino acid residues that contribute to the targeting of NBCe1 to the plasma membrane, polarized MDCK c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744ab8e39ff70790572beea58712f121
https://doi.org/10.1152/ajpcell.00147.2011

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Modulation of KV1.3 channels by protein kinase A I in T lymphocytes is mediated by the disc large 1-tyrosine kinase Lck complex

Autor: Scott M. Gordon, Lisa Neumeier, Zerrin Kuras, Ameet A. Chimote, Alexandra H. Filipovich, Volodymyr Kucher, Laura Conforti

Publikováno v: American Journal of Physiology-Cell Physiology. 302:C1504-C1512

The cAMP/PKA signaling system constitutes an inhibitory pathway in T cells and, although its biochemistry has been thoroughly investigated, its possible effects on ion channels are still not fully understood. KV1.3 channels play an important role in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbec8e1582bb919f49c2315d32ad711
https://doi.org/10.1152/ajpcell.00263.2011

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Intrinsic Voltage Dependence of the Epithelial Na+ Channel Is Masked by a Conserved Transmembrane Domain Tryptophan

Autor: Eunan Hendron, Qiusheng Tong, James D. Stockand, Elena Mironova, Nina Boiko, Volodymyr Kucher, Alexey V. Karpushev, Oleh Pochynyuk, Alexander Staruschenko

Publikováno v: Journal of Biological Chemistry. 284:25512-25521

Tryptophan residues critical to function are frequently located at the lipid-water interface of transmembrane domains. All members of the epithelial Na+ channel (ENaC)/Degenerin (Deg) channel superfamily contain an absolutely conserved Trp at the bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e522cc3615a3e4c67e5b276c9007ef57
https://doi.org/10.1074/jbc.m109.015917

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Regulation of Na+ excretion and arterial blood pressure by purinergic signalling intrinsic to the distal nephron: consequences and mechanisms

Autor: Volodymyr Kucher, Vladislav Bugaj, Elena Mironova, James D. Stockand, Nina Boiko

Publikováno v: Acta physiologica (Oxford, England). 213(1)

Discretionary control of Na(+) excretion is a key component of the regulation of arterial blood pressure in mammals. Sodium excretion is fine-tuned in the aldosterone-sensitive distal nephron by the activity of the epithelial Na(+) channel (ENaC). He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630a193bf19d93efb789fafa27d59ef9
https://pubmed.ncbi.nlm.nih.gov/25154328

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