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Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines

Autor: Akshita Pillai, Frédéric Hague, Annelise De Carvalho, Marie N. M. Volmar, Cara B. Gonzales, Alexander Kornienko, Snezna Rogelj, Véronique Mathieu, Derek C. Medellin, Nicholas F. Dybdal-Hargreaves, Gnanasekar Munirathinam, Liliya V. Frolova, Mateus Rossato, Stephen C. Pelly, João B. Calixto, Jorge J. De La Chapa, Kelsey N. Middleton, Antonio Evidente, Robert Kiss, Roland E. Kälin, Mathieu Gautier, Ramesh Dasari, Patrícia Burth, Rainer Glass, Willem A. L. van Otterlo

Publikováno v: European journal of medicinal chemistry, 103

Many types of cancer, including glioma, melanoma, non-small cell lung cancer (NSCLC), among others, are resistant to proapoptotic stimuli and thus poorly responsive to current therapies based on the induction of apoptosis in cancer cells. The current

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddd5c0086365d4dd7a7a71ead6f262a
https://doi.org/10.1016/j.ejmech.2015.08.047

Targeting APLN/APLNR Improves Antiangiogenic Efficiency and Blunts Proinvasive Side Effects of VEGFA/VEGFR2 Blockade in Glioblastoma.

Autor: Mastrella G; Neurosurgical Research, Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany., Hou M; Neurosurgical Research, Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany., Li M; Neurosurgical Research, Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany., Stoecklein VM; Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany., Zdouc N; Neurosurgical Research, Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany., Volmar MNM; Neurosurgical Research, Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany., Miletic H; Department of Biomedicine, University of Bergen, Bergen, Norway.; Department of Pathology, Haukeland University Hospital, Bergen, Norway., Reinhard S; Department of Pharmacy, LMU Munich, Munich, Germany., Herold-Mende CC; Division of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, Germany., Kleber S; Department of Molecular Neurobiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Eisenhut K; Neurosurgical Research, Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany., Gargiulo G; Max Delbrück Center for Molecular Medicine, Berlin, Germany., Synowitz M; Department of Neurosurgery, University Hospital Center Schleswig Holstein, Kiel, Germany., Vescovi AL; IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Harter PN; Edinger-Institute (Neurological Institute), Goethe-University Medical School, Frankfurt am Main, Germany and German Cancer Consortium (DKTK), partner site Frankfurt/Mainz; German Cancer Research Center (DKFZ), Heidelberg, Germany., Penninger JM; Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna, Austria., Wagner E; Department of Pharmacy, LMU Munich, Munich, Germany., Mittelbronn M; Edinger-Institute (Neurological Institute), Goethe-University Medical School, Frankfurt am Main, Germany and German Cancer Consortium (DKTK), partner site Frankfurt/Mainz; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Luxembourg Centre of Neuropathology (LCNP), Luxembourg and NORLUX Neuro-Oncology Laboratory, Luxembourg Institute of Health (LIH), and Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg., Bjerkvig R; Department of Biomedicine, University of Bergen, Bergen, Norway., Hambardzumyan D; Department of Pediatrics and Aflac Cancer Center of Children's Health Care of Atlanta, Emory University School of Medicine, Atlanta, Georgia., Schüller U; Institute of Neuropathology and Department of Pediatric Haematology and Oncology, University Medical Center, Hamburg-Eppendorf and Research Institute Children's Cancer Center, Hamburg, Germany., Tonn JC; Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany., Radke J; Department of Neuropathology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, German; Berlin Institute of Health (BIH), Berlin, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany, Partner Site Berlin, Berlin, Germany., Glass R; Neurosurgical Research, Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Walter Brendel Center of Experimental Medicine, Faculty of Medicine, LMU Munich, Munich, Germany., Kälin RE; Neurosurgical Research, Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany. roland.kaelin@med.lmu.de.; Walter Brendel Center of Experimental Medicine, Faculty of Medicine, LMU Munich, Munich, Germany.

Publikováno v: Cancer research [Cancer Res] 2019 May 01; Vol. 79 (9), pp. 2298-2313. Date of Electronic Publication: 2019 Feb 04.