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Akademický článek

ACH2.0/E, the Consolidated Theory of Conventional and Unconventional Alzheimer's Disease: Origins, Progression, and Therapeutic Strategies.

Autor: Volloch, Vladimir¹ (AUTHOR) vladimir.volloch@gmail.com, Rits-Volloch, Sophia^2,3 (AUTHOR) vladimir.volloch@gmail.com

Publikováno v: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p6036. 66p.

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Akademický článek

On the Inadequacy of the Current Transgenic Animal Models of Alzheimer's Disease: The Path Forward.

Autor: Volloch, Vladimir¹ (AUTHOR) vladimir.volloch@gmail.com, Rits-Volloch, Sophia^2,3 (AUTHOR) vladimir.volloch@gmail.com

Publikováno v: International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 5, p2981. 50p.

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Akademický článek

Next Generation Therapeutic Strategy for Treatment and Prevention of Alzheimer's Disease and Aging-Associated Cognitive Decline: Transient, Once-in-a-Lifetime-Only Depletion of Intraneuronal Aβ (i Aβ) by Its Targeted Degradation via Augmentation of Intra- i Aβ-Cleaving Activities of BACE1 and/or BACE2

Autor: Volloch, Vladimir¹ (AUTHOR) vladimir.volloch@gmail.com, Rits-Volloch, Sophia^2,3 (AUTHOR) vladimir.volloch@gmail.com

Publikováno v: International Journal of Molecular Sciences. Dec2023, Vol. 24 Issue 24, p17586. 65p.

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Akademický článek

The Amyloid Cascade Hypothesis 2.0 for Alzheimer's Disease and Aging-Associated Cognitive Decline: From Molecular Basis to Effective Therapy.

Autor: Volloch, Vladimir¹ (AUTHOR) vladimir.volloch@gmail.com, Rits-Volloch, Sophia^2,3 (AUTHOR) vladimir.volloch@gmail.com

Publikováno v: International Journal of Molecular Sciences. Aug2023, Vol. 24 Issue 15, p12246. 67p.

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Akademický článek

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Dissertation/ Thesis

Visual viscerality in the experience of contemporary cinema

Autor: Volloch, Rachel Rits

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442561

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Akademický článek

Structural basis of transmembrane coupling of the HIV-1 envelope glycoprotein

Autor: Alessandro Piai, Qingshan Fu, Yongfei Cai, Fadi Ghantous, Tianshu Xiao, Md Munan Shaik, Hanqin Peng, Sophia Rits-Volloch, Wen Chen, Michael S. Seaman, Bing Chen, James J. Chou

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

HIV-1 envelope glycoprotein (Env) mediates the fusion of viral and target cell membranes and is a major target for HIV vaccine development. Here, the authors determine the NMR structure of a bicelle incorporated Env segment comprising the transmembra

Externí odkaz: https://doaj.org/article/e13057d2254f431aa52b8fc7024ffbdf

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Effect of Lecanemab in Early Alzheimer’s Disease: Mechanistic Interpretation in the Amyloid Cascade Hypothesis 2.0 Perspective

Autor: Vladimir Volloch, Sophia Rits-Volloch

Publikováno v: Journal of Alzheimer's Disease. :1-8

In clinical trials, lecanemab showed statistically significant yet marginal slowdown of Alzheimer’s disease (AD)-associated cognitive decline. This could be due to its sub-optimal design and/or deployment; alternatively, its limited efficiency coul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea2f155736af757331f2169d33e40524
https://doi.org/10.3233/jad-230164

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The Amyloid Cascade Hypothesis 2.0: Generalization of the Concept

Autor: Vladimir Volloch, Sophia Rits-Volloch

Publikováno v: Journal of Alzheimer's Disease Reports. 7:21-35

Recently, we proposed the Amyloid Cascade Hypothesis 2.0 (ACH2.0), a reformulation of the ACH. In the former, in contrast to the latter, Alzheimer’s disease (AD) is driven by intraneuronal amyloid-β (iAβ) and occurs in two stages. In the first, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb4c399c01c90ca8ca37cd3754b5737e
https://doi.org/10.3233/adr-220079

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