Osmotic diuresis by SGLT2 inhibition stimulates vasopressin‐induced water reabsorption to maintain body fluid volume

Autor: Takahiro Masuda, Shigeaki Muto, Keiko Fukuda, Minami Watanabe, Ken Ohara, Hermann Koepsell, Volker Vallon, Daisuke Nagata

Publikováno v: Physiological Reports, Vol 8, Iss 2, Pp n/a-n/a (2020)

Abstract Most of the filtered glucose is reabsorbed in the early proximal tubule by the sodium‐glucose cotransporter SGLT2. The glycosuric effect of the SGLT2 inhibitor ipragliflozin is linked to a diuretic and natriuretic effect that activates com

Externí odkaz: https://doaj.org/article/7f897b7c175e45e0a5eefad60dc7a9bc

Expression of leptin receptor in renal tubules is sparse but implicated in leptin-dependent kidney gene expression and function

Autor: Young Chul Kim, Hadi Fattah, Yiling Fu, Josselin Nespoux, Volker Vallon

Publikováno v: American Journal of Physiology-Renal Physiology. 324:F544-F557

This study provides new insights into kidney gene expression of leptin receptor splice variants, leptin-sensitive kidney gene expression, and the role of the leptin receptor in renal tubular cells for the response to diet-induced hyperleptinemia and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f350034fc15969ad35e036d573f75d52
https://doi.org/10.1152/ajprenal.00279.2022

SGLT2 inhibitor and loop diuretic induce different vasopressin and fluid homeostatic responses in nondiabetic rats

Autor: Takahiro Masuda, Ken Ohara, Volker Vallon, Daisuke Nagata

Publikováno v: American journal of physiology. Renal physiology. 323(3)

In nondiabetic rats, the Na+-glucose cotransporter 2 (SGLT2) inhibitor ipragliflozin increased vasopressin-related stimulation of fluid intake and free water reabsorption and maintained fluid balance and serum creatinine, whereas the loop diuretic fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c13d918a88737bd8f51b1b4f0ee90a
https://pubmed.ncbi.nlm.nih.gov/35900341

Aristolochic acid-induced nephropathy is attenuated in mice lacking the neutral amino acid transporter B0AT1 (Slc6a19)

Autor: Aleix Navarro Garrido, Young Chul Kim, Yuji Oe, Haiyan Zhang, Maria Crespo-Masip, Helen A. Goodluck, Sadhana Kanoo, Paul W. Sanders, Stefan Bröer, Volker Vallon

Publikováno v: American Journal of Physiology-Renal Physiology. 323:F455-F467

Based on insights from studies manipulating glucose transport, the hypothesis has been proposed that inhibiting intestinal uptake or renal reabsorption of energy substrates has unique therapeutic potential to improve metabolic disease and kidney outc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11d83d2ded1bf31ab4034c707375eb35
https://doi.org/10.1152/ajprenal.00181.2022

Renal Clearance of Fibroblast Growth Factor-23 (FGF23) and its Fragments in Humans

Autor: Shilpa Sharma, Ronit Katz, Charles Ginsberg, Alexander Bullen, Volker Vallon, Scott Thomson, Orson W. Moe, Andrew N. Hoofnagle, Peter W. de Leeuw, Abraham A. Kroon, Alfons J.H.M. Houben, Joachim H. Ix

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, vol 37, iss 6
Journal of Bone and Mineral Research, 37(6), 1170-1178. Wiley

Relative abundance of fibroblast growth factor-23 (FGF23) measured by the C-terminal (cFGF23, which measures both intact FGF23 and C-terminal fragments) versus intact (iFGF23, measures only intact hormone) assays varies by kidney function in humans.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0925b1f4589b3c7b89a6b3f6e7e1c1
https://doi.org/10.1002/jbmr.4553