Zobrazeno 1 - 10
of 368
pro vyhledávání: '"Volker Schirrmacher"'
Autor:
Volker Schirrmacher
Publikováno v:
Immuno, Vol 3, Iss 3, Pp 289-329 (2023)
Bone marrow is known as the site of hematopoiesis. What is not being described in textbooks of immunology is the fact that bone marrow is not only a generative, but also an antigen-responsive, immune organ. It is also a major storage site for antigen
Externí odkaz:
https://doaj.org/article/654d37d1689f40e8b8f1131e2392f9a4
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 754 (2024)
Oncolytic viruses and combinatorial immunotherapy for cancer (this Special Issue) are both part of cancer treatment at IOZK. This review focusses on an individual multimodal cancer immunotherapy concept developed by IOZK, Cologne, Germany. The scient
Externí odkaz:
https://doaj.org/article/863f6a75e3c4456bbebd52873418abd5
Autor:
Peter Van de Vliet, Tobias Sprenger, Linde F. C. Kampers, Jennifer Makalowski, Volker Schirrmacher, Wilfried Stücker, Stefaan W. Van Gool
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1793 (2023)
The fundamental aim of healthcare is to improve overall health of the population by providing state-of-the-art healthcare for individuals at an affordable cost. The foundation for this system is largely referred to as “evidence-based medicine”. T
Externí odkaz:
https://doaj.org/article/32364eacfe6544a4b50fa61eadd2f743
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13050 (2022)
An apparent paradox exists between the evidence for spontaneous systemic T cell- mediated anti-tumor immune responses in cancer patients, observed particularly in their bone marrow, and local tumor growth in the periphery. This phenomenon, known as
Externí odkaz:
https://doaj.org/article/db4a69c28bf849d0893603ae354b1a7d
Autor:
Volker Schirrmacher
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 562 (2022)
Oncolytic viruses represent interesting anti-cancer agents with high tumor selectivity and immune stimulatory potential. The present review provides an update of the molecular mechanisms of the anti-neoplastic and immune stimulatory properties of the
Externí odkaz:
https://doaj.org/article/17638a92fec04716ae6413f9bebbd8cf
Autor:
Volker Schirrmacher
Publikováno v:
Biomedicines, Vol 9, Iss 3, p 293 (2021)
A dose-response relationship to stressors, according to the hormesis theory, is characterized by low-dose stimulation and high-dose inhibition. It is non-linear with a low-dose optimum. Stress responses by cells lead to adapted vitality and fitness.
Externí odkaz:
https://doaj.org/article/b6e77a72bf71428e97bc256feaf4e879
Autor:
Volker Schirrmacher
Publikováno v:
Biomedicines, Vol 8, Iss 11, p 526 (2020)
Mitochondria are of great relevance to health, and their dysregulation is associated with major chronic diseases. Research on mitochondria—156 brand new publications from 2019 and 2020—have contributed to this review. Mitochondria have been funda
Externí odkaz:
https://doaj.org/article/bf7036a4943a4f4489fbc5fde8966018
Publikováno v:
Biomedicines, Vol 8, Iss 8, p 237 (2020)
At times of personalized and individualized medicine the concept of randomized- controlled clinical trials (RCTs) is being questioned. This review article explains principles of evidence-based medicine in oncology and shows an example of how evidence
Externí odkaz:
https://doaj.org/article/3285a9e8b3bf4815883b7b64fc32ae4d
Autor:
Stefaan W. Van Gool, Jennifer Makalowski, Erin R. Bonner, Oliver Feyen, Matthias P. Domogalla, Lothar Prix, Volker Schirrmacher, Javad Nazarian, Wilfried Stuecker
Publikováno v:
Medicines, Vol 7, Iss 5, p 29 (2020)
Background: The prognosis of children with diffuse intrinsic pontine glioma (DIPG) remains dismal despite radio- and chemotherapy or molecular-targeted therapy. Immunotherapy is a powerful and promising approach for improving the overall survival (OS
Externí odkaz:
https://doaj.org/article/bca2ad1ab95149c98bc002dba8a050db
Autor:
Volker Schirrmacher
Publikováno v:
Biomedicines, Vol 8, Iss 3, p 55 (2020)
The topic is how to achieve long-term protective anti-tumor immunity by anti-cancer vaccination and what are its mechanisms. Cancer vaccines should instruct the immune system regarding relevant cancer targets and contain signals for innate immunity a
Externí odkaz:
https://doaj.org/article/c290cf1d5738414cabdbaa2f8ff0732b