Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Volker Nowotny"'
Publikováno v:
ISMB (Supplement of Bioinformatics)
Physical map assembly is the inference of genome structure from experimental data. Map assembly depends on the integration of diverse data including sequence tagged site (STS) marker content, clone sizing, and restriction digest fingerprints (RDF). A
Autor:
Marijke J. van Baren, Sumi Chakraverty, Erwin Wauters, Henry Houlden, Ben A. Oostra, Matt Baker, Mike Hutton, Alison Goate, Volker Nowotny, Jennifer M. Kwon, Susanne Froelich, Patrizia Rizzu, Corinne Lendon, John Hardy, Lars Lannfelt, Peter Heutink, Adrian M. Isaacs, Petra Nowotny
Publikováno v:
Genomics, 60, 129-136. Academic Press
Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is an autosomal dominant condition clinically characterized by behavioral, cognitive, and motor disturbances. Until now, at least 13 different FTDP-17 families that show linka
Autor:
Volker Nowotny, Mary M. Blanchard
Publikováno v:
Genetic Analysis: Biomolecular Engineering. 11:7-11
An automation-assisted method enables DNA extraction of over a thousand yeast colonies in a day by one person. Yeast DNA is extracted essentially quantitatively in three steps: (a) cells are converted into spheroplasts with yeast lytic enzyme, (b) ce
Autor:
Petra Nowotny, Jennifer M. Kwon, Alison Goate, John C. Morris, Volker Nowotny, Sumi Chakraverty
Publikováno v:
Scopus-Elsevier
The release of amyloid-beta peptide (Abeta) from beta-amyloid precursor protein (APP) requires cleavage by beta- and gamma-secretases. Several groups have identified a candidate for the beta-site APP-cleaving enzyme, BACE1, and its homologue BACE2. W
Autor:
Sang Woo Han, Volker Nowotny, Robert Clark, William J. Ray, Petra Nowotny, Kacy Philips, Ross L. Cagan, Christopher J. Jones, Alison Goate, Sharon M. Gorski
Publikováno v:
Molecular and cellular neurosciences. 15(1)
Mutations in two genes, presenilin 1 (PS1) and presenilin 2, are linked to early onset cases of familial Alzheimer's disease. The presenilins are thought to contribute to the pathogenesis of Alzheimer's disease by directly or indirectly affecting the
Autor:
Martin Rühl, Volker Nowotny, Petra Nowotny, Roland P. May, Helga Voss, Knud H. Nierhaus, Nils Burkhardt
Publikováno v:
Biophysical chemistry. 53(1-2)
Following the ‘strategy of the glassy ribosome’ single protonated ribosomal proteins (r-proteins) were reconstituted into deuterated 50S subunits of Escherichia coli . The deuteration of both rRNA and r-proteins were individually adjusted to such
Autor:
Philip Green, Michele D'Urso, LaDeana W. Hillier, David Schlessinger, Ileana Zucchi, Giovanni Porta, Volker Nowotny
Publikováno v:
Genomics. 16(2)
The contents of Alu- and L1-containing TaqI restriction fragments were assessed by Southern blot analyses across YAC contigs already assembled by other means and localized within Xq24-q28. Fingerprinting patterns of YACs in contigs were concordant, a
Publikováno v:
Genetic analysis, techniques and applications. 10(6)
Screening of collections of yeast artificial chromosomes utilizing the polymerase chain reaction (PCR) requires large numbers of reactions in parallel. Four steps were implemented to reduce the labor involved: (a) The number of initial samples for DN
Publikováno v:
The EMBO journal. 11(1)
Selected pairs of protonated ribosomal proteins were reconstituted into deuterated 50S subunits from Escherichia coli ribosomes. The rRNA of the deuterated ribosomal matrix was derived from cells grown in 76% D2O, the deuterated protein moiety from c
Publikováno v:
Proceedings, annual meeting, Electron Microscopy Society of America. 48:284-285
In earlier studies the structure of the 50S ribosomal subunit from E. coli has been determined from electron micrographs, using the single exposure random conical reconstruction technique. For the understanding of the function of ribosomes the single