A RAC-GEF network critical for early intestinal tumourigenesis

Autor: Jim Cassidy, Owen J. Sansom, William C. Clark, Luis Serrano, Volker M. Stucke, Martin J Drysdale, Martin R Turner, Arafath Kaja Najumudeen, R.P. Fordham, Karen Pickering, Lucas B. Zeiger, Ewan J. McGhee, Saskia M. Brachmann, Ann Hedley, Andrew D. Campbell, Kathryn Gilroy, Jeanette A. Johansson, Maureen M. Bain, David F. Vincent, Kevin Myant, Christina Kiel, Kurt I. Anderson, Benjamin LeRoy Miller, Angeliki Malliri, S.R. van Hoof, Sigrid K. Fey, Jan Paul Medema, E.B. Unal, Anna-Karin E. Johnsson, Catherine Nixon, Laura M. Machesky, Douglas Strathdee

Publikováno v: Nature communications, 12(1):56. Nature Publishing Group
Nature Communications
Pickering, KA, Gilroy, K, Cassidy, JW, Fey, SK, Najumudeen, AK, Zeiger, LB, Vincent, DF, Gay, DM, Johansson, J, Fordham, RP, Miller, B, Clark, W, Hedley, A, Unal, EB, Kiel, C, McGhee, E, Macheskey, LM, Nixon, C, Johnsson, AE, Bain, M, Strathdee, D, van Hoof, SR, Medema, JP, Anderson, KI, Brachmann, SM, Stucke, VM, Malliri, A, Drysdale, M, Turner, M, Serrano, L, Myant, K B, Campbell, AD & Sansom, OJ 2021, ' A RAC-GEF network critical for early intestinal tumourigenesis ', Nature Communications . https://doi.org/10.1038/s41467-020-20255-4
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
University of Edinburgh-PURE

RAC1 activity is critical for intestinal homeostasis, and is required for hyperproliferation driven by loss of the tumour suppressor gene Apc in the murine intestine. To avoid the impact of direct targeting upon homeostasis, we reasoned that indirect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a4588ea791829c408931197ab3e425
https://pure.amc.nl/en/publications/a-racgef-network-critical-for-early-intestinal-tumourigenesis(1d3b7cc2-5483-46a6-accd-e659022a288b).html

The MAGUK Protein MPP7 Binds to the Polarity Protein hDlg1 and Facilitates Epithelial Tight Junction Formation

Autor: Kris Gevaert, Volker M. Stucke, Joël Vandekerckhove, Evy Timmerman, Alan Hall

Publikováno v: Molecular Biology of the Cell, Vol. 18, no. 5, p. 1744-1755 (2007)

Three groups of evolutionarily conserved proteins have been implicated in the establishment of epithelial cell polarity: the apically-localized proteins of the Par (Par3-Par6-aPKC-Cdc42) and Crumbs groups (Crb3-PALS1-PATJ) and the basolaterally local

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c6e322758d94ddf1cdc94fd798b06e
https://doi.org/10.1091/mbc.e06-11-0980

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

Autor: Christine Stephan, William R. Sellers, Deborah Castelletti, Jeffery A. Porter, Julie L. Bernard, Sandra Mollé, Mark Stump, Tami Hood, Joshua M. Korn, Audrey Kauffmann, Giorgio G. Galli, Kristine Yu, Li Li, Marc Hattenberger, Javad Golji, Zainab Jagani, Marco Wallroth, Tobias Schmelzle, Philippe Megel, Raymond Pagliarini, Rosemary Barrett, Yingzi Yue, Richard S. Eldridge, Jan Weiler, Alberto C. Vitari, Konstantinos J. Mavrakis, Kalyani Gampa, Elizabeth Ackley, Rosalie deBeaumont, Qiong Shen, Joel Berger, Tanja Schouwey, Franklin Chung, E. Robert McDonald, Gregory McAllister, Christelle Stamm, Frances Shanahan, Aurore Desplat, Iris Kao, Thomas A. Perkins, Antoine de Weck, Kavitha Venkatesan, Albert Lai, Jennifer Johnson, Roland Widmer, David A. Ruddy, Avnish Kapoor, Brian Repko, François Gauter, Nicholas Keen, Tanushree Phadke, Eric Billy, Sosathya Sovath, Typhaine Martin, Elizabeth Frias, Justina X. Caushi, Vic E. Myer, Malini Varadarajan, William C. Forrester, Fei Feng, Hans Bitter, Ralph Tiedt, Yue Liu, Jing Zhang, Dorothee Abramowski, Dhiren Belur, Volker M. Stucke, Odile Weber, Mathias Jenal, Ali Farsidjani, Jianjun Yu, Rebecca Billig, JiaJia Feng, A. B. Meyer, Kristen Hurov, Veronica Gibaja, Michael D. Jones, Daisy Flemming, Donald A. Dwoske, Jilin Liu, Clara Delaunay, William Duong, Frank Buxton, Kaitlin J. Macchi, Saskia M. Brachmann, Alice T. Loo, Craig Mickanin, Francesco Hofmann, Frank Stegmeier, Kristy Haas, Gregory R. Hoffman, Marta Cortes-Cros, Roger Caothien, Shumei Liu, Serena J. Silver, Michael R. Schlabach, Emma Lees, Nadire Ramadan, Qiumei Liu, Zhenhai Gao

Publikováno v: Cell. 170:577-592.e10

Elucidation of the mutational landscape of human cancer has progressed rapidly and been accompanied by the development of therapeutics targeting mutant oncogenes. However, a comprehensive mapping of cancer dependencies has lagged behind and the disco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22974eb72276d42f1aa26407b00798f0
https://doi.org/10.1016/j.cell.2017.07.005

The path to oncology drug target validation: an industry perspective

Autor: Marta, Cortés-Cros, Tobias, Schmelzle, Volker M, Stucke, Francesco, Hofmann

Publikováno v: Methods in molecular biology (Clifton, N.J.). 986

The advent of a variety of genomic, proteomic and other system-based scientific approaches has raised the expectations of identifying novel targets for oncology drug discovery. However, the complexity of human genome cancer alterations requires a car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88422d19a4bfd6dfb53916eaf3ed70b9
https://pubmed.ncbi.nlm.nih.gov/23436402

Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1

Autor: Erich A. Nigg, Christoph Baumann, Volker M. Stucke

Publikováno v: Chromosoma. 113(1)

Members of the Mps1 protein kinase family have been implicated in the regulation of the kinetochore-mediated spindle assembly checkpoint in species ranging from yeast to man. However, conflicting data have been reported on the subcellular localizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9bf19d26da6e5a3a156589e464537a
https://pubmed.ncbi.nlm.nih.gov/15235793