Assessing the impact of Benzo[a]pyrene on Marine Mussels: Application of a novel targeted low density microarray complementing classical biomarker responses.

Autor: Mohamed Banni, Susanna Sforzini, Volker M Arlt, Audrey Barranger, Lorna J Dallas, Caterina Oliveri, Yann Aminot, Beniamina Pacchioni, Caterina Millino, Gerolamo Lanfranchi, James W Readman, Michael N Moore, Aldo Viarengo, Awadhesh N Jha

Publikováno v: PLoS ONE, Vol 12, Iss 6, p e0178460 (2017)

Despite the increasing use of mussels in environmental monitoring and ecotoxicological studies, their genomes and gene functions have not been thoroughly explored. Several cDNA microarrays were recently proposed for Mytilus spp., but putatively ident

Externí odkaz: https://doaj.org/article/8db0012cfe3e4470a698c73e760ebe02

C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2.

Autor: Bedoor Qabazard, Samanza Ahmed, Ling Li, Volker M Arlt, Philip K Moore, Stephen R Stürzenbaum

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e80135 (2013)

Exogenous hydrogen sulfide (H2S) administration and endogenous H2S metabolism were explored in the nematode C. elegans. Chronic treatment with a slow-releasing H2S donor, GYY4137, extended median survival by 17-23% and increased tolerance towards oxi

Externí odkaz: https://doaj.org/article/a9489aeae4c74d0eaa9292ce1d843418

Data from Environmental Pollutant and Potent Mutagen 3-Nitrobenzanthrone Forms DNA Adducts after Reduction by NAD(P)H:Quinone Oxidoreductase and Conjugation by Acetyltransferases and Sulfotransferases in Human Hepatic Cytosols

Autor: David H. Phillips, Heinz H. Schmeiser, C. Roland Wolf, Bruno Sopko, Vaclav Martinek, Eva Frei, Christian A. Bieler, Martin R. Osborne, Colin J. Henderson, Marie Stiborova, Volker M. Arlt

3-Nitrobenzanthrone (3-nitro-7H-benz[de]anthracen-7-one, 3-NBA) is a potent mutagen and suspected human carcinogen identified in diesel exhaust and air pollution. We compared the ability of human hepatic cytosolic samples to catalyze DNA adduct forma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e75705da18b3aba5471340200973db7
https://doi.org/10.1158/0008-5472.c.6494375

Metabolic Activation of Benzo[a]pyrene by Human Tissue Organoid Cultures

Autor: Angela L. Caipa Garcia, Jill E. Kucab, Halh Al-Serori, Rebekah S. S. Beck, Franziska Fischer, Matthias Hufnagel, Andrea Hartwig, Andrew Floeder, Silvia Balbo, Hayley Francies, Mathew Garnett, Meritxell Huch, Jarno Drost, Matthias Zilbauer, Volker M. Arlt, David H. Phillips

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 606
International Journal of Molecular Sciences, 24 (1), Art.Nr. 606

Peer reviewed: True
Funder: King’s College London
Funder: National Institute for Health Research (NIHR)
Organoids are 3D cultures that to some extent reproduce the structure, composition and function of the mammalian tissues from whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3520a759f6614b89125c80c958b75be9

In Vivo Metabolism of Aristolochic Acid I and II in Rats Is Influenced by Their Coexposure

Autor: Václav Martínek, František Bárta, Volker M. Arlt, Petr Hodek, Kevin Kotalík, Marie Stiborová, Alena Dedı́ková, Šárka Dušková, Jaroslav Mráz

Publikováno v: Chemical Research in Toxicology. 33:2804-2818

The plant extract aristolochic acid (AA), containing aristolochic acid I (AAI) and II (AAII) as major components, causes aristolochic acid nephropathy and Balkan endemic nephropathy, unique renal d...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4fcfd17751f58285c1aa40c80804a8f
https://doi.org/10.1021/acs.chemrestox.0c00198