Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Volker Lohmann"'
Autor:
Leonie Küchenhoff, Pascal Lukas, Camila Metz-Zumaran, Paul Rothhaar, Alessia Ruggieri, Volker Lohmann, Thomas Höfer, Megan L. Stanifer, Steeve Boulant, Soheil Rastgou Talemi, Frederik Graw
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Local cell densities and positioning within cellular monolayers and stratified epithelia have important implications for cell interactions and the functionality of various biological processes. To analyze the relationship between cell locali
Externí odkaz:
https://doaj.org/article/145f2434d0ac4799ac1864a9f488f8b2
Autor:
Keisuke Tabata, Vibhu Prasad, David Paul, Ji-Young Lee, Minh-Tu Pham, Woan-Ing Twu, Christopher J. Neufeldt, Mirko Cortese, Berati Cerikan, Yannick Stahl, Sebastian Joecks, Cong Si Tran, Christian Lüchtenborg, Philip V’kovski, Katrin Hörmann, André C. Müller, Carolin Zitzmann, Uta Haselmann, Jürgen Beneke, Lars Kaderali, Holger Erfle, Volker Thiel, Volker Lohmann, Giulio Superti-Furga, Britta Brügger, Ralf Bartenschlager
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Double membrane vesicles (DMV) are used as replication organelles by several RNA viruses. Applying proteomics and lipidomics, Tabata and Prasad et al. find that two cellular acyltransferases (AGPAT1/2), responsible for synthesis of phosphatidic acid,
Externí odkaz:
https://doaj.org/article/004cd836b49b455dbee0043b2c9d12d0
Autor:
Qian Chen, Mairene Coto-Llerena, Aleksei Suslov, Raphael Dias Teixeira, Isabel Fofana, Sandro Nuciforo, Maike Hofmann, Robert Thimme, Nina Hensel, Volker Lohmann, Charlotte K. Y. Ng, George Rosenberger, Stefan Wieland, Markus H. Heim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
A genetic variant in the IFN-lambda 4 gene has been associated with poor hepatitis C virus prognosis but it is not clear how this functions. Here the authors show that IFN-lambda 4 promotes ER stress and inhibits presentation of HCV epitopes to CD8+
Externí odkaz:
https://doaj.org/article/490276d24a40458c86a47d3c716fb078
Autor:
Daniela Nascimento Silva, Michael Chrobok, Giulia Rovesti, Katie Healy, Arnika Kathleen Wagner, Panagiota Maravelia, Francesca Gatto, Massimiliano Mazza, Lucia Mazzotti, Volker Lohmann, Margaret Sällberg Chen, Matti Sällberg, Marcus Buggert, Anna Pasetto
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cellular immunotherapies based on T cell receptor (TCR) transfer are promising approaches for the treatment of cancer and chronic viral infections. The discovery of novel receptors is expanding considerably; however, the clinical development of TCR-T
Externí odkaz:
https://doaj.org/article/fac7088d94324a579510dfff279d92eb
Autor:
Christian Heuss, Paul Rothhaar, Rani Burm, Ji-Young Lee, Philipp Ralfs, Uta Haselmann, Luisa J Ströh, Ombretta Colasanti, Cong Si Tran, Noemi Schäfer, Paul Schnitzler, Uta Merle, Ralf Bartenschlager, Arvind H Patel, Frederik Graw, Thomas Krey, Vibor Laketa, Philip Meuleman, Volker Lohmann
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010472 (2022)
Hepatitis C virus (HCV) is highly diverse and grouped into eight genotypes (gts). Infectious cell culture models are limited to a few subtypes and isolates, hampering the development of prophylactic vaccines. A consensus gt1b genome (termed GLT1) was
Externí odkaz:
https://doaj.org/article/7adc5d6f27254d5a8519af6c7a0be62e
Autor:
Philipp Schult, Hanna Roth, Rebecca L. Adams, Caroline Mas, Lionel Imbert, Christian Orlik, Alessia Ruggieri, Anna M. Pyle, Volker Lohmann
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The liver-specific microRNA-122 is an essential proviral host factor of Hepatitis C virus replication. Here the authors show that microRNA-122 functions as an RNA chaperone that guides the formation of a functional internal ribosome entry site by pre
Externí odkaz:
https://doaj.org/article/0fd247a540674475b845c754d80d8b1f
Autor:
Oliver Grünvogel, Katharina Esser-Nobis, Marc P. Windisch, Michael Frese, Martin Trippler, Ralf Bartenschlager, Volker Lohmann, Marco Binder
Publikováno v:
Genomics Data, Vol 7, Iss , Pp 166-170 (2016)
Most studies investigating the biology of Hepatitis C virus (HCV) have used the human hepatoma cell line Huh-7 or subclones thereof, as these are the most permissive cell lines for HCV infection and replication. Other cell lines also support replicat
Externí odkaz:
https://doaj.org/article/c09b8c73cbea4c2788f92047667582e4
Autor:
Sylvie Y Doerflinger, Mirko Cortese, Inés Romero-Brey, Zach Menne, Thibault Tubiana, Christian Schenk, Peter A White, Ralf Bartenschlager, Stéphane Bressanelli, Grant S Hansman, Volker Lohmann
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006705 (2017)
Human noroviruses (huNoV) are the most frequent cause of non-bacterial acute gastroenteritis worldwide, particularly genogroup II genotype 4 (GII.4) variants. The viral nonstructural (NS) proteins encoded by the ORF1 polyprotein induce vesical cluste
Externí odkaz:
https://doaj.org/article/0d46a035a2234bfda2e5807a097263ba
Autor:
Volker Klöss, Oliver Grünvogel, Guido Wabnitz, Tatjana Eigenbrod, Stefanie Ehrhardt, Felix Lasitschka, Volker Lohmann, Alexander H. Dalpke
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Innate immune cells can sense hepatitis C virus (HCV)-infected cells and respond with anti-viral actions including secretion of interferons (IFNs). In previous studies, the response of individual innate immune cells against HCV was analyzed in detail
Externí odkaz:
https://doaj.org/article/6e71a5e2fb7b4079b00307bff5f0bbcd
Autor:
Hanna Roth, Vera Magg, Fabian Uch, Pascal Mutz, Philipp Klein, Katharina Haneke, Volker Lohmann, Ralf Bartenschlager, Oliver T. Fackler, Nicolas Locker, Georg Stoecklin, Alessia Ruggieri
Publikováno v:
mBio, Vol 8, Iss 2 (2017)
Externí odkaz:
https://doaj.org/article/9ef3b5d735d4485c808d2f923d9e416a