Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Volker Haake"'
Autor:
Zhipeng Wang, Sven-Bastiaan Haange, Volker Haake, Maike Huisinga, Hennicke Kamp, Roland Buesen, Kristin Schubert, Sebastian Canzler, Jörg Hackermüller, Ulrike Rolle-Kampczyk, Martin von Bergen
Publikováno v:
Metabolites, Vol 13, Iss 7, p 847 (2023)
The thyroid hormones (THs) regulate various physiological mechanisms in mammals, such as cellular metabolism, cell structure, and membrane transport. The therapeutic drugs propylthiouracil (PTU) and phenytoin are known to induce hypothyroidism and de
Externí odkaz:
https://doaj.org/article/ec95621e8a1140688da4142d76ca9f2c
Autor:
Aishwarya Murali, Franziska Maria Zickgraf, Philipp Ternes, Varun Giri, Hunter James Cameron, Saskia Sperber, Volker Haake, Peter Driemert, Hennicke Kamp, Dorothee Funk Weyer, Shana J. Sturla, Ivonne M. G. M. Rietjens, Bennard van Ravenzwaay
Publikováno v:
Microorganisms, Vol 11, Iss 2, p 533 (2023)
An understanding of the changes in gut microbiome composition and its associated metabolic functions is important to assess the potential implications thereof on host health. Thus, to elucidate the connection between the gut microbiome and the fecal
Externí odkaz:
https://doaj.org/article/6dbd09a7cbf24cec83d21f11e56bde9d
Autor:
Véronique de Bruijn, Christina Behr, Saskia Sperber, Tilmann Walk, Philipp Ternes, Markus Slopianka, Volker Haake, Karsten Beekmann, Bennard van Ravenzwaay
Publikováno v:
Metabolites, Vol 10, Iss 6, p 242 (2020)
Various environmental factors can alter the gut microbiome’s composition and functionality, and modulate host health. In this study, the effects of oral and parenteral administration of two poorly bioavailable antibiotics (i.e., vancomycin and stre
Externí odkaz:
https://doaj.org/article/a9b34ee77ea14fbaad96bf6d269fc6eb
Autor:
Aishwarya Murali, Varun Giri, Franziska Maria Zickgraf, Philipp Ternes, Hunter James Cameron, Saskia Sperber, Volker Haake, Peter Driemert, Hennicke Kamp, Dorothee Funk-Weyer, Shana J. Sturla, Ivonne M.C.M. Rietjens, Bennard van Ravenzwaay
Publikováno v:
Chemical Research in Toxicology, 36(4), 598-616
Chemical Research in Toxicology 36 (2023) 4
Chemical Research in Toxicology 36 (2023) 4
The diversity of microbial species in the gut has a strong influence on health and development of the host. Further, there are indications that the variation in expression of gut bacterial metabolic enzymes is less diverse than the taxonomic profile,
Autor:
Sabina Ramirez-Hincapie, Barbara Birk, Philipp Ternes, Varun Giri, Volker Haake, Michael Herold, Franziska Maria Zickgraf, Andreas Verlohner, Hans-Albrecht Huener, Hennicke Kamp, Peter Driemert, Robert Landsiedel, Elke Richling, Dorothee Funk-Weyer, Bennard van Ravenzwaay
Publikováno v:
Cell Biology and Toxicology.
Cell-based metabolomics provides multiparametric physiologically relevant readouts that can be highly advantageous for improved, biologically based decision making in early stages of compound development. Here, we present the development of a 96-well
Autor:
Barbara Birk, Tilmann B. Walk, H.-A. Huener, Saskia Sperber, A. Verlohner, Michael Manfred Herold, Tzutzuy Ramirez Hernandez, Hennicke Kamp, Volker Haake, Bennard van Ravenzwaay, Meike M. Amma, Nicola J. Hewitt, Svenja K. Wallisch
Publikováno v:
Toxicology Letters. 353:43-59
We describe a strategy using an in vitro metabolomics assay with tubular rat NRK-52E cells to investigate the Modes of Action (MoAs) of nephrotoxic compounds. Chemicals were selected according to their MoAs based on literature information: acetaminop
Autor:
Lars Hareng, Paul Schuster, Volker Haake, Tilman Walk, Michael Herold, Heike Laue, Andreas Natsch
Publikováno v:
Archives of toxicology. 97(1)
Molecules metabolized to para-tert-butyl-benzoic acid (p-TBBA) affect male reproduction in rats through effects on spermatogenesis. This toxicity is specific to p-TBBA and not observed in meta-substituted analogues. The underlying mode of action was
Autor:
Pia Wilhelmi, Varun Giri, Franziska M. Zickgraf, Volker Haake, Stefan Henkes, Peter Driemert, Paul Michaelis, Wibke Busch, Stefan Scholz, Burkhard Flick, Marta Barenys, Barbara Birk, Hennicke Kamp, Robert Landsiedel, Dorothee Funk-Weyer
Publikováno v:
Chemico-Biological Interactions. :110565
Autor:
Aishwarya Murali, Varun Giri, Hunter James Cameron, Saskia Sperber, Franziska Maria Zickgraf, Volker Haake, Peter Driemert, Tilmann Walk, Hennicke Kamp, Ivonne MCM. Rietjens, Bennard van Ravenzwaay
Publikováno v:
Food and Chemical Toxicology, 165
Food and Chemical Toxicology 165 (2022)
Food and Chemical Toxicology 165 (2022)
To elucidate if artificial sweeteners modify fecal bacterial composition and the fecal and plasma metabolomes, Wistar rats from both sexes were treated for 28 days with acesulfame potassium (40 and 120 mg/kg body weight) and saccharin (20 and 100 mg/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ef681caf9434656576763608920a1f
https://research.wur.nl/en/publications/investigating-the-gut-microbiome-and-metabolome-following-treatme
https://research.wur.nl/en/publications/investigating-the-gut-microbiome-and-metabolome-following-treatme
Autor:
Angelika, Langsch, Raymond M, David, Steffen, Schneider, Saskia, Sperber, Volker, Haake, Hennicke, Kamp, Edgar, Leibold, Bennard van, Ravenzwaay, Rainer, Otter
Publikováno v:
Toxicology letters. 288
Hexamoll