Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Volker Fehring"'
Autor:
Katrin Radloff, Birgitt Gutbier, Charlotte Maeve Dunne, Hanieh Moradian, Marko Schwestka, Manfred Gossen, Katharina Ahrens, Laura Kneller, Yadong Wang, Akanksha Moga, Leonidas Gkionis, Oliver Keil, Volker Fehring, Daniel Tondera, Klaus Giese, Ansgar Santel, Jörg Kaufmann, Martin Witzenrath
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102068- (2023)
Dysfunction of endothelial cells (ECs) lining the inner surface of blood vessels are causative for a number of diseases. Hence, the ability to therapeutically modulate gene expression within ECs is of high therapeutic value in treating diseases such
Externí odkaz:
https://doaj.org/article/5eca547cc46b4d08ba4476f7d8468a32
Autor:
Maria Thomas, Malte Brensel, Kira Roth, Berit Genz, Ute Schaeper, Brigitte Vollmar, Kerstin Abshagen, Volker Fehring
Publikováno v:
Current Gene Therapy. 15:215-227
Activation of hepatic stellate cells (HSCs) is a key event in pathogenesis of liver fibrosis and represents an orchestral interplay of inhibiting and activating transcription factors like forkhead box f1 (Foxf1), being described to stimulate pro-fibr
Autor:
Kerstin Abshagen, Ulf Schulze-Topphoff, Michael Thrum, Brigitte Vollmar, Volker Fehring, Angela Kuhla, Ute Schaeper
Publikováno v:
Apoptosis : an international journal on programmed cell death. 20(4)
Acute liver failure (ALF) is a life threatening disease for which only few treatment options exist. The molecular pathways of disease progression are not well defined, but the death receptor Fas (CD95/Apo-1) appears to play a pivotal role in hepatocy
Publikováno v:
Org. Biomol. Chem.. 1:123-128
The ability of 2'-alpha-C-carboxyalkyl nucleosides to undergo an unusual two-step stereocontrolled nucleobase exchange process has been investigated. Upon silylation a protected 2'-deoxy-2'-alpha-C-(carboxymethyl)uridine derivative can undergo intram
Publikováno v:
Targeted oncology. 10(3)
The overexpression of membrane-bound complement regulatory proteins (mCRP; CD46, CD55, CD59) preventing opsonization and complement-dependent cytotoxicity (CDC) is considered a major barrier for successful antibody-based cancer immunotherapy. To avoi
Publikováno v:
ELECTROPHORESIS. 22:4383-4390
The identification of pancreatic proteins is generally hampered by the high content and activity of proteases produced by this organ. The aim of this work was the development of a protocol for the analysis of pancreatic juice by two-dimensional (2-D)
Publikováno v:
ELECTROPHORESIS. 22:2903-2907
The quantitative comparison of spot patterns relies heavily on protein stains that do provide an appropriate dynamic range. Unfortunately most spot picking robot devices are still limited to nonfluorescent protein stains and the appropriate equipment
Publikováno v:
Journal of Organometallic Chemistry. 621:120-129
Chiral rhodium(I) chelates containing a seven-membered ring are well-known active catalysts for the asymmetric hydrogenation of amino acid precursors. A high conformational flexibility allows their enantioselectivity to be strongly influenced by modi
Autor:
Franziska Faltin, Renat Kadyrov, Volker Fehring, Antonio Arrieta, Ralf Miethchen, Rüdiger Selke, Thomas Schareina
Publikováno v:
Synthesis. 2001:0638-0646
Autor:
Rüdiger Selke, Volker Fehring
Publikováno v:
Angewandte Chemie International Edition. 37:1827-1830
A breakthrough for the rhodium-catalyzed asymmetric, homogeneous hydrogenation of unfunctionalized ketones was recently achieved by Zhang et al. with the synthesis and use of ligands 1, named PennPhos, which combine high basisity and optimal spatial