Induction of the chromosomal translocation t(14;18) by targeting the BCL-2 locus with specific binding I-125-labeled triplex-forming oligonucleotides

Autor: Volker Dahmen, Ralf Kriehuber, Sabine Schmitz

Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 823:58-64

Triplex-Forming oligonucleotides (TFO) bind sequence-specific to the DNA double helix in-vitro and in-vivo and are a promising tool to manipulate genes or gene regulatory elements. TFO as a carrier molecule for short-range particle emitter such as Au

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2efbd187f30b264b80bf6a6ab5488441
https://doi.org/10.1016/j.mrgentox.2017.09.002

Cytotoxic effects and specific gene expression alterations induced by I-125-labeled triplex-forming oligonucleotides

Autor: Volker Dahmen, Ralf Kriehuber

Publikováno v: International journal of radiation biology 88(12), 972-979 (2012). doi:10.3109/09553002.2012.702298
7th International Symposium on Physical, Molecular, Cellular and Medical Aspects of Auger, Jülich, Germany, 2011-08-24-2011-08-26
International Journal of Radiation Biology

Triplex-forming oligonucleotides (TFOs) are able to bind DNA in a sequence specific manner and are a promising tool to manipulate genes or gene regulatory units in a cellular environment. TFOs posses also a potential for radiotherapy e.g. as a carrie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4d83812464c3d662bcc2b1067f4720
https://doi.org/10.3109/09553002.2012.702298