Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Volker C. Kirsch"'
Autor:
Pavel Kielkowski, Isabel Y. Buchsbaum, Volker C. Kirsch, Nina C. Bach, Micha Drukker, Silvia Cappello, Stephan A. Sieber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Protein AMPylation is a post-translational modification whose implications in cellular physiology are not fully understood. Here the authors develop a cell-permeable AMPylation probe and use it to identify new AMP modified proteins and investigate th
Externí odkaz:
https://doaj.org/article/dc0d7f0727124aa5ad2c40e99753071c
Publikováno v:
Journal of Proteome Research. 20:867-879
Staphylococcus aureus represents an opportunistic pathogen, which utilizes elaborate quorum sensing mechanisms to precisely control the expression and secretion of virulence factors. Previous studies indicated a role of the ClpXP proteolytic system i
Publikováno v:
Angewandte Chemie. 132:12456-12460
Autor:
Nina C. Bach, Isabel Y. Buchsbaum, Volker C. Kirsch, Pavel Kielkowski, Silvia Cappello, Stephan A. Sieber, Micha Drukker
Publikováno v:
Nature Communications
Nat. Commun. 11:517 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nat. Commun. 11:517 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Posttranslational modification (PTM) of proteins represents an important cellular mechanism for controlling diverse functions such as signalling, localisation or protein–protein interactions. AMPylation (also termed adenylylation) has recently been
Publikováno v:
Angewandte Chemie (International Ed. in English)
The first total synthesis of vioprolide D was accomplished in an overall yield of 2.0 % starting from methyl (2S)‐3‐benzyloxy‐2‐hydroxypropanoate (16 steps in the longest linear sequence). The cyclic depsipeptide was assembled from two buildi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5cfd9ac04066c6beca133c3d94de66
https://mediatum.ub.tum.de/1547338
https://mediatum.ub.tum.de/1547338
Autor:
Franziska A. Mandl, Stephan A. Sieber, Klaus Richter, Ilke Ugur, Christian Fetzer, Iris Antes, Jan Vomacka, Volker C. Kirsch, Thilo M. Fuchs, Sabine Schneider, Elena Kunold
Publikováno v:
Angewandte Chemie International Edition. 55:14852-14857
Gram-negative bacteria represent a challenging task for antibacterial drug discovery owing to their impermeable cell membrane and restricted uptake of small molecules. We herein describe the synthesis of natural-product-derived epoxycyclohexenones an
Autor:
Elena Kunold, Klaus Richter, Ilke Ugur, Iris Antes, Jan Vomacka, Volker C. Kirsch, Stephan A. Sieber, Franziska A. Mandl, Thilo M. Fuchs, Christian Fetzer, Sabine Schneider
Publikováno v:
Angewandte Chemie. 128:15074-15079
Aufgrund ihrer undurchlassigeren Zellmembran und der damit verbundenen eingeschrankten Aufnahme von niedermolekularen Verbindungen stellen Gram-negative Bakterien eine grose Herausforderung fur die Entwicklung neuer Antibiotika dar. Hier wurden natur
Autor:
Rolf Müller, Christina Orgler, Simone Braig, Stephan A. Sieber, Irmela Jeremias, David Auerbach, Angelika M. Vollmar, Volker C. Kirsch
Publikováno v:
Angewandte Chemie (International ed. in English)
Angew. Chem.-Int. Edit. 59, 1595-1600 (2019)
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angew. Chem.-Int. Edit. 59, 1595-1600 (2019)
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Novel targets are needed for treatment of devastating diseases such as cancer. For decades, natural products have guided innovative therapies by addressing diverse pathways. Inspired by the potent cytotoxic bioactivity of myxobacterial vioprolides A
Autor:
Sabine Schneider, Nina C. Bach, Matthew B. Nodwell, Martin Pfanzelt, Stephan A. Sieber, Volker C. Kirsch, Matthias Stahl, Annabelle Hoegl
Publikováno v:
Nature Chemistry
Nature chemistry
Nature chemistry
Pyridoxal phosphate (PLP) is an enzyme cofactor required for the chemical transformation of biological amines in many central cellular processes. PLP-dependent enzymes (PLP-DEs) are ubiquitous and evolutionarily diverse, making their classification b