Zobrazeno 1 - 10
of 296
pro vyhledávání: '"Volker Brinkmann"'
Autor:
Naveen Kumar, Pon Ganish Prakash, Christian Wentland, Shilpa Mary Kurian, Gaurav Jethva, Volker Brinkmann, Hans-Joachim Mollenkopf, Tobias Krammer, Christophe Toussaint, Antoine-Emmanuel Saliba, Matthias Biebl, Christian Jürgensen, Bertram Wiedenmann, Thomas F. Meyer, Rajendra Kumar Gurumurthy, Cindrilla Chumduri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The gastroesophageal squamocolumnar junction (GE-SCJ) is a critical tissue interface between the esophagus and stomach, with significant relevance in the pathophysiology of gastrointestinal diseases. Despite this, the molecular mechanisms un
Externí odkaz:
https://doaj.org/article/92e5c859ad5a452d9912442eb093da20
Autor:
Natalie E. Nieuwenhuizen, Geraldine Nouailles, Jayne S. Sutherland, Joanna Zyla, Arja H. Pasternack, Jan Heyckendorf, Björn C. Frye, Kerstin Höhne, Ulrike Zedler, Silke Bandermann, Ulrike Abu Abed, Volker Brinkmann, Birgitt Gutbier, Martin Witzenrath, Norbert Suttorp, Gernot Zissel, Christoph Lange, Olli Ritvos, Stefan H. E. Kaufmann
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Activin A strongly influences immune responses; yet, few studies have examined its role in infectious diseases. We measured serum activin A levels in two independent tuberculosis (TB) patient cohorts and in patients with pneumonia and sarcoi
Externí odkaz:
https://doaj.org/article/3d3667d5541a46edbd2bf30cc823eefc
Autor:
Stefanie Koster, Rajendra Kumar Gurumurthy, Naveen Kumar, Pon Ganish Prakash, Jayabhuvaneshwari Dhanraj, Sofia Bayer, Hilmar Berger, Shilpa Mary Kurian, Marina Drabkina, Hans-Joachim Mollenkopf, Christian Goosmann, Volker Brinkmann, Zachary Nagel, Mandy Mangler, Thomas F. Meyer, Cindrilla Chumduri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, Koster et al., model human papillomavirus and Chlamydia coinfection dynamics in patient-derived ectocervical organoids, and characterize the effects of multiple infections in the cellular microenvironment, potentially contributing to neoplasia.
Externí odkaz:
https://doaj.org/article/2fb21c954d7549fe9ee43a376dd4e07a
Autor:
Hellen Buijze, Volker Brinkmann, Robert Hurwitz, Anca Dorhoi, Stefan H. E. Kaufmann, Gang Pei
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9701 (2023)
Mouse guanylate-binding proteins (mGBPs) are recruited to various invasive pathogens, thereby conferring cell-autonomous immunity against these pathogens. However, whether and how human GBPs (hGBPs) target M. tuberculosis (Mtb) and L. monocytogenes (
Externí odkaz:
https://doaj.org/article/f5a2f46974924e9888c068ba221f7e60
Autor:
Dorothea Ogmore Tilley, Ulrike Abuabed, Ursula Zimny Arndt, Monika Schmid, Stefan Florian, Peter R Jungblut, Volker Brinkmann, Alf Herzig, Arturo Zychlinsky
Publikováno v:
eLife, Vol 11 (2022)
Neutrophils are critical to host defence, executing diverse strategies to perform their antimicrobial and regulatory functions. One tactic is the production of neutrophil extracellular traps (NETs). In response to certain stimuli, neutrophils deconde
Externí odkaz:
https://doaj.org/article/d8e432b742664c989e77339c1d4ebdff
Autor:
Gopinath Krishnamoorthy, Peggy Kaiser, Patricia Constant, Ulrike Abu Abed, Monika Schmid, Christian K. Frese, Volker Brinkmann, Mamadou Daffé, Stefan H. E. Kaufmann
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Mycofactocin is a new class of peptide-derived redox cofactors present in a selected group of bacteria including Mycobacterium tuberculosis. Mycofactocin biosynthesis requires at least six genes, including mftD, encoding putative lactate deh
Externí odkaz:
https://doaj.org/article/6d1b9d18c5514c898bf4807ce058aaa7
Autor:
Julian Heuberger, Jakob Trimpert, Daria Vladimirova, Christian Goosmann, Manqiang Lin, Rosa Schmuck, Hans‐Joachim Mollenkopf, Volker Brinkmann, Frank Tacke, Nikolaus Osterrieder, Michael Sigal
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
Abstract SARS‐CoV‐2, the agent that causes COVID‐19, invades epithelial cells, including those of the respiratory and gastrointestinal mucosa, using angiotensin‐converting enzyme‐2 (ACE2) as a receptor. Subsequent inflammation can promote r
Externí odkaz:
https://doaj.org/article/5396e49c30f44e5e8e0a119b1c47a08f
Autor:
Mirjana Kessler, Karen Hoffmann, Kristin Fritsche, Volker Brinkmann, Hans-Joachim Mollenkopf, Oliver Thieck, Ana Rita Teixeira da Costa, Elena I. Braicu, Jalid Sehouli, Mandy Mangler, Hilmar Berger, Thomas F. Meyer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Chronic infections of the fallopian tubes with Chlamydia trachomatis can cause scarring and infertility. Here, the authors show that the pathogen alters stem cell differentiation and DNA methylation in human fallopian tube organoids, suggesting a pot
Externí odkaz:
https://doaj.org/article/500f18ebcdd2438f989609ef929e9def
Autor:
Gopinath Krishnamoorthy, Peggy Kaiser, Ulrike Abu Abed, January Weiner, Pedro Moura-Alves, Volker Brinkmann, Stefan H. E. Kaufmann
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 3 (2020)
Lactate dehydrogenase A (LDHA) mediates interconversion of pyruvate and lactate, and increased lactate turnover is exhibited by malignant and infected immune cells. Hypoxic lung granuloma in Mycobacterium tuberculosis-infected animals present elevate
Externí odkaz:
https://doaj.org/article/1d4e6545a6c14d64b47bf69114bc310d
Autor:
Stephanie Zimmermann, Lennart Pfannkuch, Munir A. Al-Zeer, Sina Bartfeld, Manuel Koch, Jianping Liu, Cindy Rechner, Meike Soerensen, Olga Sokolova, Alla Zamyatina, Paul Kosma, André P. Mäurer, Frithjof Glowinski, Klaus-Peter Pleissner, Monika Schmid, Volker Brinkmann, Alexander Karlas, Michael Naumann, Marion Rother, Nikolaus Machuy, Thomas F. Meyer
Publikováno v:
Cell Reports, Vol 20, Iss 10, Pp 2384-2395 (2017)
Activation of transcription factor NF-κB is a hallmark of infection with the gastric pathogen Helicobacter pylori, associated with inflammation and carcinogenesis. Genome-wide RNAi screening revealed numerous host factors involved in H. pylori-, but
Externí odkaz:
https://doaj.org/article/a311253e5c6b4ba68a84b4953a760d72